Diane Krause, MD, PhD, is a physician-scientist with over two decades of experience in cell transplant therapies for patients with leukemia and other blood diseases. As medical director of Yale Cancer Center’s Advanced Cell Therapy Laboratory, Dr. Krause oversees the development of therapies designed to help boost patients’ immune systems. “It’s a state-of-the-art facility,” Dr. Krause says, of the lab. “Only the top cancer centers have a laboratory like this.”
Bone marrow transplantation is an example of a cellular therapy that most people have heard of – but, explains Dr. Krause, current cellular therapies go far beyond that and have the potential to become routine treatments in the near future. She and lab members are researching ways to harness the manufacturing of a patient’s immune cells that express chimeric antigen receptors (CARs), a burgeoning area within cancer immunotherapy treatment. “We are seizing the opportunity,” she says.
At Yale School of Medicine, Dr. Krause serves as associate director of the Yale Stem Cell Center and is professor of laboratory medicine, of cell biology, and of pathology.