Many people, over the course of their lives, have experienced acute stress, a dramatic physiological and psychological reaction to a specific event. Chronic stress, however, is a consistent sense of feeling pressured and overwhelmed over a long period of time. “We humans are very good at facing a challenge, solving a situation, or reaching out to someone to get support,” says Rajita Sinha, PhD, director of Yale Medicine’s Interdisciplinary Stress Center. “We’re wired to respond to stress and remove it, sometimes even automatically. But life has become more complex, and many situations don’t have easy answers.” Sinha founded the Yale Stress Center in 2007 to study stress from an interdisciplinary perspective and to improve the treatment of stress-related diseases.