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Phase Pilot

The interaction of flavor with nicotine form in adult smokers

  • Study HIC#:2000025687
  • Last Updated:11/11/2022

This study seeks to elucidate the impact of e-cigarette flavor on subjective effects and nicotine exposure from e-cigarettes containing different forms of nicotine.

  • Age21 years and older
  • GenderBoth
  • Start Date01/16/2020
  • End Date05/31/2022

Trial Purpose and Description

This study seeks to elucidate the impact of e-cigarette flavor on subjective effects and nicotine exposure from e-cigarettes containing different forms of nicotine.

Eligibility Criteria

Inclusion:

  • At least 21 years of age
  • Able to read and write English
  • Smoking at least 5 menthol cigarettes/cigars/little cigars per day
  • Report regular menthol cigarette use
  • CO≥10 ppm and have at least 200ng/ml urine cotinine
  • Willing to abstain from combustible tobacco products 12 hrs prior to each experimental session.
  • not planning a smoking quit attempt.
  • Have not stopped use due to COVID.
  • used e-cigarettes at least 10 times in the past six months.
  • Fully vaccinated against COVID-19.

Exclusions:

  • Use of psychoactive drugs including anxiolytics, antidepressants, and other psychostimulants unless prescribed and stable for two months.
  • Current diagnosis of any severe psychiatric disorder
  • Any significant current medical condition such as neurological, cardiovascular, endocrine, renal, pulmonary or hepatic pathology that would increase risk or would interfere with/mimic tobacco abstinence.
  • Known hypersensitivity to propylene glycol and nut allergies.
  • Pregnant or lactating females.
  • current criteria for moderate or severe cannabis and alcohol use disorder per DSM-5 criteria.
  • current criteria for other substance use disorders per DSM-5 criteria.
  • Seeking treatment to stop smoking.
  • individuals who do not want to use e-cigarettes.
  • Uncontrolled asthma (defined as <20 on Asthma Control Test)
  • blood pressure >170/>100 and heart rate >100
  • vaping of CBD/THC or marijuana related products in the past 3 months
  • Known to have allergies, multiple chemical sensitivities, asthma, or other airway sensitivities.

Principal Investigator

Sub-Investigators

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