Acute Effects of THC in Older Adult
- Study HIC#:2000038388
- Last Updated:10/03/2025
You are invited to participate in a research study designed to examine how aging influences the acute effects of delta-9-tetrahydrocannabinol (THC), the principal active constituent of cannabis/marijuana. This study is sponsored and funded by the National Institute on Drug Abuse. This study will help older adults about the risks and benefits of cannabis. Participation in this research study will take a total of approximately 12 hours, spread out over one screening session (approximately 4 hours), and one dosing day (approximately 8 hours). On the dosing day, you will receive 2 of the following: placebo, low dose THC and medium dose THC. There will also be brief follow-up telephone questionnaires administered approximately 24 hours, 1 month, 3 months and 6 months after the dosing day.
Study Visits:
- Visit 1: In-Person Screening Visit
- Visit 2: Test Day, in which you will receive 2 of the following: placebo, low dose THC and medium dose THC
- Telephone questionnaires (24 hours, 1 month, 3 months and 6 months after test days)
Compensation: $50 for screening and $300 for the test day, for a total of up to $350.
Contact Us
For more information about this study, including how to volunteer, contact:
Research Coordinator
- Phone Number: 1-203-937-3830
Help Us Discover!
You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact helpusdiscover@yale.edu, or call +18779788343 for more information.
Eligibility Criteria
Inclusion/Exclusion Criteria:
1. Aged 21 years and older
2. At least one use of cannabis and/or THC in the past ten years
3. Negative urine screen for illicit substance use, at screening and on test days (excluding for cannabinoids)
4. No history of serious or urgent medical or neurological problems
5. No personal or family history of psychosis or a psychotic illness in a first degree relative
6. Weight ≤ 220 lbs (100kg)
7. High school education or greater
8. English speaking