SPARK: Simons Foundation Powering Autism Research for Knowledge, a national cohort of individuals and families affected by Autism Spectrum Disorder
- Study HIC#:2000024931
- Last Updated:07/15/2021
|SPARK study at Yale - all ages welcome
SPARK is a growing community of individuals, families, and researchers on a mission to speed up the understanding of autism. Our aims are to:
- Start Date10/16/2019
- End Date12/31/2025
Trial Purpose and Description
The purpose of SPARK: Simons Foundation Powering Autism Research for Knowledge (hereinafter referred to as SPARK) is to recruit, engage, and retain a community of 50,000 individuals with ASD along with their family members in the United States to identify the causes of ASD, accelerate clinical research by providing the autism research community with a genotyped cohort of consented participants, and establish a research cohort of individuals and families with ASD. The data generated will facilitate identification of additional genes that contribute strongly to ASD and define their corresponding genotype-phenotype relationships. Data from this cohort will also help identify additional non-genetic causes of ASD. A long term goal of SPARK is to enable genotype-driven clinical research in ASD, which may translate into genotype-driven therapeutics and treatment of ASD. This type of precision medicine approach is an emerging strategy for disease treatment and prevention that takes into account individual genetic variability, environment, and lifestyle. Noteworthy advances in precision medicine have been made for specific cancers, but precision treatments are not currently available for most diseases. Many researchers are working towards precision medicine, and SPARK is one such project. A limited data set from this study will be made available to qualified researchers, so that scientific and treatment advances can be made as rapidly as possible.
All children and adults with a professional diagnosis of ASD who live in the United States are eligible to participate in this study. Biological or adoptive parents, legally authorized representatives (LARs), and full biological siblings who live in the United States are also eligible to participate.