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Phase II

A Study of Brenipatide (GLP-1) in Adult Participants With Schizophrenia (RENEW-Scz-1)

  • Study IRB#:2000041368
  • Last Updated:07/31/2026

The purpose of this research study is to learn more about brenipatide (a GLP-1) , a possible new investigational drug for the treatment of schizophrenia.

The study aims to see:

  • Whether the drug is effective alongside participant's standard schizophrenia treatment
  • Whether the drug helps weight loss/management
  • Whether the drug helps thinking and memory
  • Whether the drug prevents schizophrenia symptoms from returning

Requirements and What’s Involved:

To be in this study you must:
  • Be Diagnosed with Schizophrenia
  • Be Age 18-55
  • Have a BMI of >22
  • Be Willing to participate for a full year and take drug once a week during this period
  • This includes 14 in-person visits, 10 telehealth visits
  • These visits include clinical assessments, physical assessments, blood testing, urine testing etc.
  • Stay on their current schizophrenia standard of care for the whole study
  • Have a study partner accompany you to in-person visits
  • This is a person that knows you well, that can answer questions about you and how you’re feeling
Payments:

The participant will be paid ~$100 per study visit and the study partner will be paid this amount for the in-person visits that they come to.

    If you’re interested please contact us at:

    Email: cholab@yale.edu

    Phone: 475-355-3029

    For more information visit our website

      Contact Us

      For more information about this study, including how to volunteer, contact:

      Gabrielle Baugh

      Help Us Discover!

      You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact helpusdiscover@yale.edu, or call +18779788343 for more information.

      Eligibility Criteria

      Participants must be:

      • Age 18-55
      • Diagnosed with Schizophrenia
      • Taking no more than 2 anti-psychotics

      Principal Investigator

      Sub-Investigators

      For more information about this study, including how to volunteer, contact: