Phase II
A Study of Brenipatide (GLP-1) in Adult Participants With Schizophrenia (RENEW-Scz-1)
- Study IRB#:2000041368
- Last Updated:07/31/2026
The purpose of this research study is to learn more about brenipatide (a GLP-1) , a possible new investigational drug for the treatment of schizophrenia.
The study aims to see:
- Whether the drug is effective alongside participant's standard schizophrenia treatment
- Whether the drug helps weight loss/management
- Whether the drug helps thinking and memory
- Whether the drug prevents schizophrenia symptoms from returning
Requirements and What’s Involved:
To be in this study you must:
- Be Diagnosed with Schizophrenia
- Be Age 18-55
- Have a BMI of >22
- Be Willing to participate for a full year and take drug once a week during this period
- This includes 14 in-person visits, 10 telehealth visits
- These visits include clinical assessments, physical assessments, blood testing, urine testing etc.
- Stay on their current schizophrenia standard of care for the whole study
- Have a study partner accompany you to in-person visits
- This is a person that knows you well, that can answer questions about you and how you’re feeling
Payments:
The participant will be paid ~$100 per study visit and the study partner will be paid this amount for the in-person visits that they come to.
If you’re interested please contact us at:
Email: cholab@yale.edu
Phone: 475-355-3029
For more information visit our website
Contact Us
For more information about this study, including how to volunteer, contact:
Gabrielle Baugh
- Phone Number: 1-475-355-3029
Help Us Discover!
You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact helpusdiscover@yale.edu, or call +18779788343 for more information.
Eligibility Criteria
Participants must be:
- Age 18-55
- Diagnosed with Schizophrenia
- Taking no more than 2 anti-psychotics