Pathogenic Mechanisms of Obesity and its Cardiometabolic Complications

Our research team is studying the effects of insulin resistance on metabolic processes and if it can be reversible. Insulin resistance has a higher prevalence rate in overweight/obese children than normal weight children. Roughly 20% of youth in the United States are overweight/obese, putting them at a higher risk of developing insulin resistance. By studying these groups, we aim to address how fat cells break down stored fat in response to metabolic processes, and how this is affected by insulin resistance. Furthermore, we aim to assess if physical activity may restore these responses. We are looking for adolescents ages 15-22 who are considered overweight/obese and are not on any weight loss medication. Participants will complete 3-5 research visits, as well as be enrolled in our physical exercise program that will take place remotely 3 times per week for 12 weeks. As part of the study, participants will gain valuable health insights, including whether they have prediabetes, diabetes, or insulin resistance with results shared with their provider as well as guidance on dietary health. Participants may be compensated for up to $505.