Neurofeedback for Obsessive-Compulsive Disorder

The aim of this study is to train patients with obsessive-compulsive disorder to control a region of their brain that has been associated with their symptoms. Patients in the experimental group will be given direct feedback regarding activity in this brain area while they are undergoing functional magnetic resonance imaging (fMRI) scanning, and will try to learn to control activity in the region during these feedback sessions. A separate group of patients will be given a control form of feedback that we do not believe can have clinical benefits. Our primary hypothesis is that the neurofeedback training will reduce OCD symptoms more than the control feedback.

Participants will be compensated with up to $460 cash over the course of the entire study.

For more information on this study: Call +1 (203) 737-6055, leaving a voicemail with your name, phone number, and a time to reach you. Or, email ocdnfresearch@yale.edu.

Inclusion Criteria:

• Primary Diagnosis of current OCD, based on Diagnostic and Statistical Manual (DSM-IV) criteria, a Y-BOCS (Yale-Brown Obsessive-Compulsive Scale) score >=16
• Principle OCD symptoms- Primary symptoms must be either Cleaning/Contamination or Checking; other symptoms okay
• Aged 18-65
• Unmedicated (or medications stable for 8 weeks)
• Research group must be able to identify a target region in the orbitofrontal cortex that is related to symptoms

Exclusion Criteria:

• Active Psychosis; Pervasive Developmental Disorder ; epilepsy or other major neurological disorder
• History of major head trauma or psychosurgery
• Active Substance Abuse within 6 months
• Seizure disorder or other significant neurological disorder
• Active suicidality
• Pregnancy
• Severe claustrophobia, ferromagnetic metal in the body, a pacemaker or defibrillator, or any other condition that would make MRI scanning unsafe or inappropriate
• Any psychotropic medication other than a selective serotonin reuptake inhibitor (SSRI) antidepressant, anafranil, or a low-dose hypnotic or anxiolytic taken on an as-needed basis
• Active cognitive/behavioral therapy initiated within the last 3 months (continuation of established maintenance therapy that has been going on for longer than 3 months will not be grounds for exclusion)