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Phase Pilot

Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo using 11C-UCB-J PET

  • Study HIC#:2000021843
  • Last Updated:07/15/2021

Looking for individuals between 21 and 55 years old currently abusing opiates and not taking medication for it (i.e., Methadone or Buprenorphine).  This research study is designed to explore how opiate addiction influences synaptic density. This relationship will be explored in the brain’s prefrontal cortex, an area important in decision-making and impulsivity. In this study, subjects will participate in one 11C-UCB-J Positron Emission Tomography (PET) scan and one structural and functional resting state Magnetic Resonance Imaging (MRI) scan.

This is an inpatient study up to 4 weeks that requires managed abstinence. 

  • Start Date01/29/2019
  • End Date10/31/2022

Trial Purpose and Description

Exploratory/Developmental Aim: To measure synaptic density in the brains (including in ventral striatum [VS] and medial prefrontal cortex [mPFC]) of abstinent subjects with Cocaine Use Disorder (CUD) or Opiate Use Disorder (OUD) as compared to healthy control (HC) subjects using 11C-UCB-J PET.

Eligibility Criteria

Eligibility criteria: 

21-55 years old, currently dependent on opiates and not taking medication for it, physically healthy, no significant medical or neurological illness.

This is an inpatient study up to 4 weeks that requires managed abstinence. 

Compensation up to $1400

Principal Investigator

Sub-Investigators

  • Ming-Kai Chen

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