Joao P. De Aquino, MD
Psychiatry, Addiction Medicine
Titles
- Assistant Professor of Psychiatry
- Assistant Chief of the Clinical Neuroscience Research Unit (CNRU), Psychiatry
Education & Training
- Advanced Research FellowshipYale University & VA VISN-1 Mental Illness Research, Education, and Clinical Center (MIRECC) (2021)
- Addiction Psychiatry FellowshipYale University (2019)
- Psychiatry ResidencyYale University (2018)
- MDFederal University of Ceara, School of Medicine (2012)
Languages Spoken
- English
- Français (French)
- Português (Portuguese)
- Español (Spanish)
Additional Information
Honors & Recognitions
- NIH Early Career Reviewer: National Institute of Health (NIH) Center for Scientific Review (2023)
- ASCP New Investigator Award: American Society of Clinical Psychopharmacology (ASCP) (2023)
- ISCTM New Investigator Award: International Society of CNS Clinical Trials and Methodology (ISCTM) (2023)
- COVID-19 Fund to Retain Clinical Scientists : Doris Duke Foundation and Yale Center for Clinical Investigation (YCCI) (2023)
- IMPOWR-YOU Pilot Award: Integrative Management of Chronic Pain and Opioid Use Disorder for Whole Recovery-Yale Organizations United (IMPOWR-YOU) Research Center (2022)
- ACNP Past Travel Awardee Progress Funding: American College of Neuropsychopharmacology (ACNP) (2022)
- CPDD Early Career Investigator Travel Award: College on Problems of Drug Dependence (CPDD) (2022)
- ACNP Travel Award: American College of Neuropsychopharmacology (ACNP) (2021)
- K23 Mentored Patient-Oriented Research Career Development Award: National Institute of Drug Abuse (NIDA) (2021)
- Mentored Clinical Research Award: Robert E. Leet and Clara Guthrie Patterson Trust (2019)
Professional Service
- American Society of Clinical Psychopharmacology (ASCP) (2023 - Present): ASCP Early Career Committee
- National Institute of Health (NIH) (2023 - 2024): Neurobiology of Pain and Itch (NPI) Study Section
- British Journal of Clinical Psychopharmacology (2023 - Present): Guest Editor
- Experimental and Clinical Psychopharmacology (2022 - Present): Editorial Board Member
- Janeway Society (2022 - Present): Council Member
- College on Problems of Drug Dependence (CPDD) (2022 - Present): Human Research Committee
- Frontiers Psychiatry Addictive Disorders (2021 - Present): Editorial Board Member
Publications
- Oliveira, D., Fontenele, R., Weleff, J., Sofuoglu, M., & De Aquino, J. P. (2023). Developing non-opioid therapeutics to alleviate pain among persons with opioid use disorder: a review of the human evidence. International Review of Psychiatry, 1-20.
- De Aquino JP, Bahji A, Gomez OG, Sofuoglu M. Alleviation of Opioid Withdrawal by Cannabis and Delta-9-Tetrahydrocannabinol: A Systematic Review of Observational and Experimental Human Studies. Drug and Alcohol Dependence.
- De Aquino JP, Parida S, Avila-Quintero VJ, Flores J, Compton P, Hickey T, Gómez O, Sofuoglu M. Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies. Drug And Alcohol Dependence 2021, 228: 109097. PMID: 34601272, PMCID: PMC8595687, DOI: 10.1016/j.drugalcdep.2021.109097.
- De Aquino, JP, Meyerovich, J, Xie, CZ, et al. Delta-9-tetrahydrocannabinol modulates pain sensitivity among persons receiving opioid agonist therapy for opioid use disorder: A within-subject, randomized, placebo-controlled laboratory study. Addiction Biology. 2023; 28 (9):e13317. doi:10.1111/adb.13317
- Ranganathan M, De Aquino JP, Cortes-Briones JA, Radhakrishnan R, Pittman B, Bhakta S, D’Souza D. Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans. Psychopharmacology 2019, 236: 3209-3219. PMID: 31187152, DOI: 10.1007/s00213-019-05273-5.
- De Aquino JP, Flores JM, Avila‐Quintero V, Compton P, Sofuoglu M. Pharmacological treatment of pain among persons with opioid addiction: A systematic review and meta‐analysis with implications for drug development. Addiction Biology 2020, 26: e12964. PMID: 32974993, DOI: 10.1111/adb.12964.
- Sugarman DE, De Aquino JP, Poling J, Sofuoglu M. Feasibility and effects of galantamine on cognition in humans with cannabis use disorder. Pharmacology Biochemistry And Behavior 2019, 181: 86-92. PMID: 31082417, PMCID: PMC6545124, DOI: 10.1016/j.pbb.2019.05.004.
- Schwartz EKC, Wolkowicz NR, De Aquino JP, MacLean RR, Sofuoglu M. Cocaine Use Disorder (CUD): Current Clinical Perspectives. Substance Abuse And Rehabilitation 2022, 13: 25-46. PMID: 36093428, PMCID: PMC9451050, DOI: 10.2147/sar.s337338.
- Martins B, Rutland W, De Aquino JP, Kazer BL, Funaro M, Potenza MN, Angarita GA. Helpful or Harmful? The Therapeutic Potential of Medications with Varying Degrees of Abuse Liability in the Treatment of Substance Use Disorders. Current Addiction Reports 2022, 9: 647-659. PMID: 35990796, PMCID: PMC9376579, DOI: 10.1007/s40429-022-00432-9.
- De Aquino JP, DeVito EE, Xie C, Meyerovich J, Parida S, Gueorguieva R, Sofuoglu M. Development of pulsed intravenous nicotine infusions as a model for inhaled nicotine in humans. Psychopharmacology 2022, 239: 2809-2818. PMID: 35554617, DOI: 10.1007/s00213-022-06162-0.
- Jegede O, Parida S, De Aquino JP. Buprenorphine Treatment of Fentanyl-Related Opioid Use Disorder. The Primary Care Companion For CNS Disorders 2022, 24 PMID: 35486939, DOI: 10.4088/pcc.21cr03163.
- Selloni A, Bhatia G, Ranganathan M, De Aquino JP. Multimodal Correlates of Cannabis Use among U.S. Veterans with Bipolar Disorder: An Integrated Study of Clinical, Cognitive, and Functional Outcomes. Journal Of Dual Diagnosis 2022, 18: 81-91. PMID: 35430960, PMCID: PMC9794455, DOI: 10.1080/15504263.2022.2053264.
- Florence L, Lassi DLS, Kortas GT, Lima DR, de Azevedo-Marques Périco C, Andrade AG, Torales J, Ventriglio A, De Berardis D, De Aquino JP, Castaldelli-Maia JM. Brain Correlates of the Alcohol Use Disorder Pharmacotherapy Response: A Systematic Review of Neuroimaging Studies. Brain Sciences 2022, 12 PMID: 35326342, PMCID: PMC8946664, DOI: 10.3390/brainsci12030386.
- De Aquino JP, MacLean RR, Gueorguieva R, DeVito EE, Eid T, Sofuoglu M. Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science. Addiction Biology 2022, 27: e13161. PMID: 35229960, PMCID: PMC8903077, DOI: 10.1111/adb.13161.
- Jegede O, Parida S, De Aquino JP. Buprenorphine treatment of fentanyl-related opioid use disorder. Prim Care Companion CNS Disord. 2022;24(3):21cr03163.
- De Aquino JP, Bahji A, D'Souza DC. Letter to the Editor: Cannabis as a Solution to the Opioid Crisis: Is the Cart Before the Horse Again? Cannabis And Cannabinoid Research 2021, 7: 898-900. PMID: 34714101, PMCID: PMC9784580, DOI: 10.1089/can.2021.0155.
- De Aquino JP, Parida S, Sofuoglu M. Buprenorphine Microinduction: Logistical Barriers and the Need for Convergent Evidence. Clinical Drug Investigation 2021, 41: 665-665. PMID: 34106434, DOI: 10.1007/s40261-021-01049-y.
- De Aquino JP, Parida S, Sofuoglu M. The Pharmacology of Buprenorphine Microinduction for Opioid Use Disorder. Clinical Drug Investigation 2021, 41: 425-436. PMID: 33818748, PMCID: PMC8020374, DOI: 10.1007/s40261-021-01032-7.
- Wright M, De Aquino JP, Bystrak T. Case report: Increasing the frequency of intramuscular naltrexone administration in a high risk patient with opioid use disorder. Substance Abuse : Official Publication Of The Association For Medical Education And Research In Substance Abuse 2021, 1-7. PMID: 33689592, DOI: 10.1080/08897077.2021.1876811.
- Joao P. De Aquino, Suprit Parida, Victor J. Avila-Quintero, Jose Flores, R.N. Peggy Compton, Thomas Hickey, Oscar Gómez, Mehmet Sofuoglu. Opioid-Induced Analgesia Among Persons with Opioid Use Disorder Receiving Methadone or Buprenorphine: A Systematic Review of Experimental Pain Studies. Drug and Alcohol Dependence. 109097. ISSN 0376-8716.
- De Aquino JP, Bahji A, D'Souza DC (2021) Letter to the Editor: Cannabis as a solution to the opioid crisis: Is the cart before the horse again?, Cannabis and Cannabinoid Research X:X, 1–3, DOI: 10.1089/can.2021.0155.
- De Aquino, JP, MacLean, RR, Gueorguieva, R, DeVito, EE, Eid, T, Sofuoglu, M. Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science. Addiction Biology. 2022; 27 (2):e13161. doi:10.1111/adb.13161
- De Aquino JP, Sofuoglu M, Stefanovics EA, Rosenheck RA. Impact of cannabis on non-medical opioid use and symptoms of posttraumatic stress disorder: a nationwide longitudinal VA study. The American Journal Of Drug And Alcohol Abuse 2020, 46: 812-822. PMID: 33035104, DOI: 10.1080/00952990.2020.1818248.
- De Aquino JP, Fairgrieve C, Klaire S, Garcia-Vassallo G. Rapid Transition From Methadone to Buprenorphine Utilizing a Micro-dosing Protocol in the Outpatient Veteran Affairs Setting. Journal Of Addiction Medicine 2020 PMID: 32011408, DOI: 10.1097/ADM.0000000000000618.
- Bommersbach T, Ross DA, De Aquino JP. Perpetual Hunger: The Neurobiological Consequences of Long-Term Opioid Use. Biological Psychiatry 2020, 87: e1-e3. PMID: 31806086, PMCID: PMC7830805, DOI: 10.1016/j.biopsych.2019.10.007.
- Parida S, De Aquino JP, Sofuoglu M. High potency synthetic opioids: Curbing the third wave of the opioid crisis. Neuroscience & Biobehavioral Reviews 2019, 106: 9-10. PMID: 31251966, DOI: 10.1016/j.neubiorev.2019.06.019.
- De Aquino JP, Sofuoglu M, Stefanovics E, Rosenheck R. Adverse Consequences of Co-Occurring Opioid Use Disorder and Cannabis Use Disorder Compared to Opioid Use Disorder Only. The American Journal Of Drug And Alcohol Abuse 2019, 45: 527-537. PMID: 31112429, DOI: 10.1080/00952990.2019.1607363.
- Gupta S, De Aquino JP, D’Souza D, Ranganathan M. Effects of haloperidol on the delta-9-tetrahydrocannabinol response in humans: a responder analysis. Psychopharmacology 2019, 236: 2635-2640. PMID: 30919005, PMCID: PMC6697616, DOI: 10.1007/s00213-019-05235-x.
- De Aquino JP, Moore DT, Wilkins K, Fuehrlein B. Enhancement of Medical Student Attitudes in the Treatment of Patients with Substance Use Disorders: a Follow-up Study. Academic Psychiatry 2019, 43: 350-351. PMID: 30756269, DOI: 10.1007/s40596-019-01038-6.
- De Aquino JP, Ross DA. Cannabinoids and Pain: Weeding Out Undesired Effects With a Novel Approach to Analgesia. Biological Psychiatry 2018, 84: e67-e69. PMID: 30360776, PMCID: PMC6697049, DOI: 10.1016/j.biopsych.2018.09.003.
- De Aquino JP, Sherif M, Radhakrishnan R, Cahill JD, Ranganathan M, D'Souza D. The Psychiatric Consequences of Cannabinoids. Clinical Therapeutics 2018, 40: 1448-1456. PMID: 29678279, DOI: 10.1016/j.clinthera.2018.03.013.
- De Aquino JP, Ross DA. Kraepelin’s Crumbling Twin Pillars: Using Biology to Reconstruct Psychiatric Nosology From the Bottom Up. Biological Psychiatry 2017, 82: e71-e74. PMID: 29031920, PMCID: PMC5714270, DOI: 10.1016/j.biopsych.2017.09.008.
- Lima JP, Brophy JM. The potential interaction between clopidogrel and proton pump inhibitors: a systematic review. BMC Medicine 2010, 8: 81. PMID: 21134261, PMCID: PMC3016262, DOI: 10.1186/1741-7015-8-81.
- de Aquino Lima JP, Brophy JM. Conflicting evidence: what's a clinician to do? Annals Of Internal Medicine 2010, 153: 413-5. PMID: 20855806, DOI: 10.7326/0003-4819-153-6-201009210-00011.
Titles
- Assistant Professor of Psychiatry
- Assistant Chief of the Clinical Neuroscience Research Unit (CNRU), Psychiatry
Education & Training
- Advanced Research FellowshipYale University & VA VISN-1 Mental Illness Research, Education, and Clinical Center (MIRECC) (2021)
- Addiction Psychiatry FellowshipYale University (2019)
- Psychiatry ResidencyYale University (2018)
- MDFederal University of Ceara, School of Medicine (2012)
Languages Spoken
- English
- Français (French)
- Português (Portuguese)
- Español (Spanish)
Additional Information
Honors & Recognitions
- NIH Early Career Reviewer: National Institute of Health (NIH) Center for Scientific Review (2023)
- ASCP New Investigator Award: American Society of Clinical Psychopharmacology (ASCP) (2023)
- ISCTM New Investigator Award: International Society of CNS Clinical Trials and Methodology (ISCTM) (2023)
- COVID-19 Fund to Retain Clinical Scientists : Doris Duke Foundation and Yale Center for Clinical Investigation (YCCI) (2023)
- IMPOWR-YOU Pilot Award: Integrative Management of Chronic Pain and Opioid Use Disorder for Whole Recovery-Yale Organizations United (IMPOWR-YOU) Research Center (2022)
- ACNP Past Travel Awardee Progress Funding: American College of Neuropsychopharmacology (ACNP) (2022)
- CPDD Early Career Investigator Travel Award: College on Problems of Drug Dependence (CPDD) (2022)
- ACNP Travel Award: American College of Neuropsychopharmacology (ACNP) (2021)
- K23 Mentored Patient-Oriented Research Career Development Award: National Institute of Drug Abuse (NIDA) (2021)
- Mentored Clinical Research Award: Robert E. Leet and Clara Guthrie Patterson Trust (2019)
Professional Service
- American Society of Clinical Psychopharmacology (ASCP) (2023 - Present): ASCP Early Career Committee
- National Institute of Health (NIH) (2023 - 2024): Neurobiology of Pain and Itch (NPI) Study Section
- British Journal of Clinical Psychopharmacology (2023 - Present): Guest Editor
- Experimental and Clinical Psychopharmacology (2022 - Present): Editorial Board Member
- Janeway Society (2022 - Present): Council Member
- College on Problems of Drug Dependence (CPDD) (2022 - Present): Human Research Committee
- Frontiers Psychiatry Addictive Disorders (2021 - Present): Editorial Board Member
Publications
- Oliveira, D., Fontenele, R., Weleff, J., Sofuoglu, M., & De Aquino, J. P. (2023). Developing non-opioid therapeutics to alleviate pain among persons with opioid use disorder: a review of the human evidence. International Review of Psychiatry, 1-20.
- De Aquino JP, Bahji A, Gomez OG, Sofuoglu M. Alleviation of Opioid Withdrawal by Cannabis and Delta-9-Tetrahydrocannabinol: A Systematic Review of Observational and Experimental Human Studies. Drug and Alcohol Dependence.
- De Aquino JP, Parida S, Avila-Quintero VJ, Flores J, Compton P, Hickey T, Gómez O, Sofuoglu M. Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies. Drug And Alcohol Dependence 2021, 228: 109097. PMID: 34601272, PMCID: PMC8595687, DOI: 10.1016/j.drugalcdep.2021.109097.
- De Aquino, JP, Meyerovich, J, Xie, CZ, et al. Delta-9-tetrahydrocannabinol modulates pain sensitivity among persons receiving opioid agonist therapy for opioid use disorder: A within-subject, randomized, placebo-controlled laboratory study. Addiction Biology. 2023; 28 (9):e13317. doi:10.1111/adb.13317
- Ranganathan M, De Aquino JP, Cortes-Briones JA, Radhakrishnan R, Pittman B, Bhakta S, D’Souza D. Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans. Psychopharmacology 2019, 236: 3209-3219. PMID: 31187152, DOI: 10.1007/s00213-019-05273-5.
- De Aquino JP, Flores JM, Avila‐Quintero V, Compton P, Sofuoglu M. Pharmacological treatment of pain among persons with opioid addiction: A systematic review and meta‐analysis with implications for drug development. Addiction Biology 2020, 26: e12964. PMID: 32974993, DOI: 10.1111/adb.12964.
- Sugarman DE, De Aquino JP, Poling J, Sofuoglu M. Feasibility and effects of galantamine on cognition in humans with cannabis use disorder. Pharmacology Biochemistry And Behavior 2019, 181: 86-92. PMID: 31082417, PMCID: PMC6545124, DOI: 10.1016/j.pbb.2019.05.004.
- Schwartz EKC, Wolkowicz NR, De Aquino JP, MacLean RR, Sofuoglu M. Cocaine Use Disorder (CUD): Current Clinical Perspectives. Substance Abuse And Rehabilitation 2022, 13: 25-46. PMID: 36093428, PMCID: PMC9451050, DOI: 10.2147/sar.s337338.
- Martins B, Rutland W, De Aquino JP, Kazer BL, Funaro M, Potenza MN, Angarita GA. Helpful or Harmful? The Therapeutic Potential of Medications with Varying Degrees of Abuse Liability in the Treatment of Substance Use Disorders. Current Addiction Reports 2022, 9: 647-659. PMID: 35990796, PMCID: PMC9376579, DOI: 10.1007/s40429-022-00432-9.
- De Aquino JP, DeVito EE, Xie C, Meyerovich J, Parida S, Gueorguieva R, Sofuoglu M. Development of pulsed intravenous nicotine infusions as a model for inhaled nicotine in humans. Psychopharmacology 2022, 239: 2809-2818. PMID: 35554617, DOI: 10.1007/s00213-022-06162-0.
- Jegede O, Parida S, De Aquino JP. Buprenorphine Treatment of Fentanyl-Related Opioid Use Disorder. The Primary Care Companion For CNS Disorders 2022, 24 PMID: 35486939, DOI: 10.4088/pcc.21cr03163.
- Selloni A, Bhatia G, Ranganathan M, De Aquino JP. Multimodal Correlates of Cannabis Use among U.S. Veterans with Bipolar Disorder: An Integrated Study of Clinical, Cognitive, and Functional Outcomes. Journal Of Dual Diagnosis 2022, 18: 81-91. PMID: 35430960, PMCID: PMC9794455, DOI: 10.1080/15504263.2022.2053264.
- Florence L, Lassi DLS, Kortas GT, Lima DR, de Azevedo-Marques Périco C, Andrade AG, Torales J, Ventriglio A, De Berardis D, De Aquino JP, Castaldelli-Maia JM. Brain Correlates of the Alcohol Use Disorder Pharmacotherapy Response: A Systematic Review of Neuroimaging Studies. Brain Sciences 2022, 12 PMID: 35326342, PMCID: PMC8946664, DOI: 10.3390/brainsci12030386.
- De Aquino JP, MacLean RR, Gueorguieva R, DeVito EE, Eid T, Sofuoglu M. Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science. Addiction Biology 2022, 27: e13161. PMID: 35229960, PMCID: PMC8903077, DOI: 10.1111/adb.13161.
- Jegede O, Parida S, De Aquino JP. Buprenorphine treatment of fentanyl-related opioid use disorder. Prim Care Companion CNS Disord. 2022;24(3):21cr03163.
- De Aquino JP, Bahji A, D'Souza DC. Letter to the Editor: Cannabis as a Solution to the Opioid Crisis: Is the Cart Before the Horse Again? Cannabis And Cannabinoid Research 2021, 7: 898-900. PMID: 34714101, PMCID: PMC9784580, DOI: 10.1089/can.2021.0155.
- De Aquino JP, Parida S, Sofuoglu M. Buprenorphine Microinduction: Logistical Barriers and the Need for Convergent Evidence. Clinical Drug Investigation 2021, 41: 665-665. PMID: 34106434, DOI: 10.1007/s40261-021-01049-y.
- De Aquino JP, Parida S, Sofuoglu M. The Pharmacology of Buprenorphine Microinduction for Opioid Use Disorder. Clinical Drug Investigation 2021, 41: 425-436. PMID: 33818748, PMCID: PMC8020374, DOI: 10.1007/s40261-021-01032-7.
- Wright M, De Aquino JP, Bystrak T. Case report: Increasing the frequency of intramuscular naltrexone administration in a high risk patient with opioid use disorder. Substance Abuse : Official Publication Of The Association For Medical Education And Research In Substance Abuse 2021, 1-7. PMID: 33689592, DOI: 10.1080/08897077.2021.1876811.
- Joao P. De Aquino, Suprit Parida, Victor J. Avila-Quintero, Jose Flores, R.N. Peggy Compton, Thomas Hickey, Oscar Gómez, Mehmet Sofuoglu. Opioid-Induced Analgesia Among Persons with Opioid Use Disorder Receiving Methadone or Buprenorphine: A Systematic Review of Experimental Pain Studies. Drug and Alcohol Dependence. 109097. ISSN 0376-8716.
- De Aquino JP, Bahji A, D'Souza DC (2021) Letter to the Editor: Cannabis as a solution to the opioid crisis: Is the cart before the horse again?, Cannabis and Cannabinoid Research X:X, 1–3, DOI: 10.1089/can.2021.0155.
- De Aquino, JP, MacLean, RR, Gueorguieva, R, DeVito, EE, Eid, T, Sofuoglu, M. Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science. Addiction Biology. 2022; 27 (2):e13161. doi:10.1111/adb.13161
- De Aquino JP, Sofuoglu M, Stefanovics EA, Rosenheck RA. Impact of cannabis on non-medical opioid use and symptoms of posttraumatic stress disorder: a nationwide longitudinal VA study. The American Journal Of Drug And Alcohol Abuse 2020, 46: 812-822. PMID: 33035104, DOI: 10.1080/00952990.2020.1818248.
- De Aquino JP, Fairgrieve C, Klaire S, Garcia-Vassallo G. Rapid Transition From Methadone to Buprenorphine Utilizing a Micro-dosing Protocol in the Outpatient Veteran Affairs Setting. Journal Of Addiction Medicine 2020 PMID: 32011408, DOI: 10.1097/ADM.0000000000000618.
- Bommersbach T, Ross DA, De Aquino JP. Perpetual Hunger: The Neurobiological Consequences of Long-Term Opioid Use. Biological Psychiatry 2020, 87: e1-e3. PMID: 31806086, PMCID: PMC7830805, DOI: 10.1016/j.biopsych.2019.10.007.
- Parida S, De Aquino JP, Sofuoglu M. High potency synthetic opioids: Curbing the third wave of the opioid crisis. Neuroscience & Biobehavioral Reviews 2019, 106: 9-10. PMID: 31251966, DOI: 10.1016/j.neubiorev.2019.06.019.
- De Aquino JP, Sofuoglu M, Stefanovics E, Rosenheck R. Adverse Consequences of Co-Occurring Opioid Use Disorder and Cannabis Use Disorder Compared to Opioid Use Disorder Only. The American Journal Of Drug And Alcohol Abuse 2019, 45: 527-537. PMID: 31112429, DOI: 10.1080/00952990.2019.1607363.
- Gupta S, De Aquino JP, D’Souza D, Ranganathan M. Effects of haloperidol on the delta-9-tetrahydrocannabinol response in humans: a responder analysis. Psychopharmacology 2019, 236: 2635-2640. PMID: 30919005, PMCID: PMC6697616, DOI: 10.1007/s00213-019-05235-x.
- De Aquino JP, Moore DT, Wilkins K, Fuehrlein B. Enhancement of Medical Student Attitudes in the Treatment of Patients with Substance Use Disorders: a Follow-up Study. Academic Psychiatry 2019, 43: 350-351. PMID: 30756269, DOI: 10.1007/s40596-019-01038-6.
- De Aquino JP, Ross DA. Cannabinoids and Pain: Weeding Out Undesired Effects With a Novel Approach to Analgesia. Biological Psychiatry 2018, 84: e67-e69. PMID: 30360776, PMCID: PMC6697049, DOI: 10.1016/j.biopsych.2018.09.003.
- De Aquino JP, Sherif M, Radhakrishnan R, Cahill JD, Ranganathan M, D'Souza D. The Psychiatric Consequences of Cannabinoids. Clinical Therapeutics 2018, 40: 1448-1456. PMID: 29678279, DOI: 10.1016/j.clinthera.2018.03.013.
- De Aquino JP, Ross DA. Kraepelin’s Crumbling Twin Pillars: Using Biology to Reconstruct Psychiatric Nosology From the Bottom Up. Biological Psychiatry 2017, 82: e71-e74. PMID: 29031920, PMCID: PMC5714270, DOI: 10.1016/j.biopsych.2017.09.008.
- Lima JP, Brophy JM. The potential interaction between clopidogrel and proton pump inhibitors: a systematic review. BMC Medicine 2010, 8: 81. PMID: 21134261, PMCID: PMC3016262, DOI: 10.1186/1741-7015-8-81.
- de Aquino Lima JP, Brophy JM. Conflicting evidence: what's a clinician to do? Annals Of Internal Medicine 2010, 153: 413-5. PMID: 20855806, DOI: 10.7326/0003-4819-153-6-201009210-00011.