Dr. Besse received her bachelors degree in Biomedical Engineering at Brown University in 2003, then her M.D. from the University of Connecticut School of Medicine in 2009. She came to Yale for Internal Medicine Residency and has remained at Yale for her clinical and research training in Nephrology. Dr. Besse joined the faculty of the Department of Internal Medicine, Section of Nephrology in 2018. Her research training in Nephrology has been under the mentorship of Dr. Stefan Somlo, C.N.H Long Professor of Medicine (Nephrology) and Professor of Genetics.
Dr. Besse's field of research interest is genetic kidney diseases, with initial focus on polycystic kidney disease. She uses genetic approaches to identify novel disease genes for dominantly inherited polycystic kidney and liver diseases: a phenotypic spectrum from autosomal dominant polycystic kidney disease (ADPKD) to isolated polycystic liver disease (PCLD). Her identification and investigation of multiple genes thus far using cell lines generated by CRISPR and model models has contributed understanding to how the central PKD protein, Polycystin-1, matures through the endoplasmic reticulum. She hopes to continue to investigate mechanisms of genetic kidney diseases with the goal of identifying a target for treatment or cure.