Peyronie's Disease

This information is useful for children and adults
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Why Yale Medicine?
  • Our experts in male sexual dysfunction have vast expertise in treating Peyronie’s disease.
  • We are one of the main referral centers in the Northeast for treatment of Peyronie’s disease
  • We personalize care to the patient, offering all treatments including medication and precision surgical reconstruction.
  • Yale Medicine participated in the clinical trials that led to the first approved drug to treat the condition.

An injury to the penis isn’t something most men want to think about, but it can happen, potentially causing curvature and shortening of the penis. This condition is called Peyronie’s disease, and it can make intercourse difficult or impossible, says Stanton Honig, MD, a urologic surgeon who heads Yale Medicine’s Male Sexual Medicine and Male Reproductive Health programs.

Although Peyronie’s disease isn’t a widely known condition, it is more common than you might guess, affecting about 1 in 11 men.

Until recently, surgery was the only effective treatment for Peyronie’s disease. Dr. Honig participated in clinical trials for the first drug approved by the Food and Drug Administration (FDA) for treatment of Peyrone’s disease, collaganese (brand name: Xiaflex). “I think the fact that we have an FDA-approved drug is really a breakthrough in this disease,” he says.

When the penis is injured, micro-bleeding and inflammation result. This may lead to the development of scar tissue (called plaque) in the shaft of the penis. Scar tissue may cause the penis to begin to curve or bend, potentially interfering a man’s ability to have sexual intercourse.

The disease has a major impact on a man’s wellbeing, including not only sexual function and physical appearance, but also psychological health. “About 50 percent of people with this disease have some level of depression,” says Dr. Honig.