Peripheral Vascular Disease

This information is useful for adults and older adults
50 year old man on the couch with glasses reading a newspaper.
Why Yale Medicine?
  • Yale Medicine is a world leader in research involving peripheral vascular disorders.
  • Our doctors emphasize non-invasive and minimally invasive therapies.
  • We conduct multiple ongoing clinical trials to improve outcomes for people with PVD.

In healthy adults, blood flows freely through veins and arteries like a stream. However, when that stream gets gunked  up, blood flow can be restricted. Peripheral vascular disease, or PVD, is a systemic disorder that involves the narrowing of peripheral blood vessels (vessels situated away from the heart or the brain) as a result of arteriosclerosis, or a buildup of plaque. This can happen with veins or arteries. 

When plaque accumulates, it may result in blood clots and dangerously limit the amount of oxygen that circulates to the arms and legs. The condition often causes pain and discomfort while walking. If peripheral vascular disease goes untreated, there is a chance that it may progress into critical limb ischemia (CLI), a severe stage of PVD that can result in the loss of an affected limb. But if caught in its early stages, peripheral vascular disease is a treatable and reversible disease. Specialists at Yale Medicine take a multidisciplinary approach to treating peripheral vascular disease and critical limb ischemia to improve outcomes and the quality of patients’ lives.

Clinical Trials

New treatments for many conditions are tested in clinical trials, which ultimately bring lifesaving new drugs and devices to the patients who need them most. By participating in a clinical trial, you may get access to the most advanced treatments for your condition, and help determine their benefits for future patients.