The TIPI Study
- Study HIC#:2000028329
- Last Updated:08/22/2023
The purpose of this research is to find out if a single dose of pre-travel vaccination with BCG (a living organism preparation) can lessen Tuberculosis (TB) infection by producing an immune response (development of TB fighter cells within the body) when given to adults traveling to countries with a high burden of TB. BCG will be compared with a placebo (an inactive vaccine). Participants will be randomly assigned (this is like a coin flip) to receive BCG vaccine or placebo.
- Age18 years - 65 years
- GenderBoth
Contact Us
For more information about this study, including how to volunteer, contact:
Anousheh Behnegar
- Phone Number: 1-203-737-6372
Help Us Discover!
You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact helpusdiscover@yale.edu, or call +18779788343 for more information.
Trial Purpose and Description
The purpose of this research is to find out if a single dose of pre-travel vaccination with BCG (a living organism preparation) can lessen Tuberculosis (TB) infection by producing an immune response (development of TB fighter cells within the body) when given to adults traveling to countries with a high burden of TB. BCG will be compared with a placebo (an inactive vaccine). Participants will be randomly assigned (this is like a coin flip) to receive BCG vaccine or placebo.
Eligibility Criteria
- Participant is age 18-65
- Participant has no known history of Mtb infection or HIV infection
- Participant has no prior history of BCG vaccination, or previous receipt of an investigational Mtb vaccine
- Participant is assessed to be at risk for TB exposure (particularly drug resistant TB) during planned travel and has planned to work in high TB burden countries for a duration of >4 weeks and <6 months for HCW, or ≥6 months and ≤2.5 years if long term traveler and/or/HCW
- Participant presents for study screening at least 4 weeks prior to travel departure
