Platelet function in sick children
- Study HIC#:2000039293
- Last Updated:05/12/2025
The study will look at the function of platelets when a number of organs in the body are not functioning properly. Platelets are small cells in your blood that prevent or stop bleeding.
Contact Us
For more information about this study, including how to volunteer, contact:
Andrea DeClement
- Phone Number: 1-203-785-4651
Help Us Discover!
You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact helpusdiscover@yale.edu, or call +18779788343 for more information.
Trial Purpose and Description
The unique features of pediatric platelet response to stress, specifically the unfolded protein response (UPR), and their differential response from adult platelets continue to be unexplored. We will determine these pediatric platelet responses, particularly in the setting of multiple organ dysfunction syndrome (MODS). Our central hypothesis states that hyperinflammation causes severe endoplasmic reticulum (ER) stress and overwhelms the UPR leading to platelet dysfunction in children. This platelet dysfunction contributes to thrombosis, thrombocytopenia, then MODS. But the UPR can be modulated to prevent these complications. Overall, our proposed research could lead to the identification and development of pediatric-specific antiplatelet therapies for MODS. Using classical and innovative techniques, we will systematically elucidate platelet morphology and function in healthy children and those with MODS. We will compare platelet responses between children with and without MODS, and between healthy children and young adults.
Eligibility Criteria
(1) children <18 years old who are admitted to the intensive care unit, OR
(2) healthy children not admitted to the hospital, OR
(3) healthy young adults 18-25 years old not admitted to the hospital
