Skip to Main Content
Phase Pilot

Postoperative Dexamethasone on Post-Cesarean Pain

  • Study HIC#:2000025968
  • Last Updated:06/19/2024

For this study, the researchers are most interested in an option that would be able to be administered consistently (same time/same way): that labor nurses could give and without requiring the patient to have had an epidural placement. Further, Gabapentin, clonidine and ketamine are associated with CNS effects like sedation or confusion that could make health care providers less likely to be comfortable giving these women additional oxycodone due to possible worsened sedation or respiratory depression. Lastly, the researchers wanted to give a drug that both obstetricians and pediatricians were comfortable with from extensive use in our maternal population. Thus, a single administration IV dexamethasone was chosen for this study. Dexamethasone has been used as an adjunct for post-operative pain management in many types of surgeries. Although no large randomized trials exist, several small trials suggest an analgesic and opioid sparing effect of dexamethasone post-operatively for both pregnant and non-pregnanat patients; however these studies excluded patients on MAT

  • Age18 years and older
  • GenderFemale only

Contact Us

For more information about this study, including how to volunteer, contact:

Victoria Wesevich

Help Us Discover!

You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact, or call +18779788343 for more information.

Trial Purpose and Description

Investigating if giving perioperative dexamethasone to pregnant patients on medication assisted treatment improves their pain scores and decreases their opioid use after cesarean section.

Eligibility Criteria

Inclusion Criteria:

  • English-speaking,
  • History of opioid use disorder with current use of MAT during pregnancy,
  • Scheduled for cesarean delivery for their current pregnancy for any indication [examples of elective c-section (decision made for c-section to be performed prior to onset of labor): fetal malpresentation, suspected macrosomia, prior c-section, abnormal placentation, patient preference],
  • Negative toxicology screen upon admission to the hospital for their cesarean section, no prior administration of betamethasone for fetal lung maturity within 24h of their scheduled cesarean delivery

Exclusion Criteria:

  • non-english speaking,
  • screen positive for illicit substance(s) on their admission toxicology screen,
  • require general anesthesia for their cesarean section due to maternal/fetal indication for non-anticipated urgency (thus no longer 'elective') or failure of adequate intra- operative pain control with spinal anesthesia,
  • medical history including known cardiovascular disease, heart failure, uncontrolled hypertension, uncontrolled gestational diabetes or uncontrolled pregestational diabetes, active GI bleed or untreated peptic ulcer,
  • untreated infectious diseases including tuberculosis, systemic candida

Principal Investigator


For more information about this study, including how to volunteer, contact: