Neurobiological Responses in Alcoholism and Early Trauma
- Study HIC#:2000024809
- Last Updated:02/22/2024
Early trauma is associated with clinical challenges in treatment alcoholism, including complex clinical symptoms and higher relapse rates. To better understand this phenomena, this study will examine the neurobiological mechanisms underlying alcoholism, early trauma, and high relapse risk. The current study utilizes a multimodal neuroimaging technique combining brain and hypothalamic-pituitary-adrenal axis (HPA) measures in a prospective clinical outcome design.
- Age21 years - 55 years
- GenderBoth
Contact Us
For more information about this study, including how to volunteer, contact:
Rachel Hart
- Phone Number: 1-888-978-7377
Help Us Discover!
You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact helpusdiscover@yale.edu, or call +18779788343 for more information.
Trial Purpose and Description
The current research proposes to investigate neurobiological mechanisms of comorbid AUD and ET and their prospective prediction of alcohol relapse using a multimodal neuroimaging technique that combines functional magnetic resonance imaging (fMRI) and HPA axis measures.
Eligibility Criteria
Criteria
AUD inclusion Criteria:
- Alcohol use disorder
- Either low or high early trauma (based on the Childhood Trauma Questionnaire)
- Body mass index (BMI) up to 35 (due to weight limitations of the MRI scanner)
AUD exclusion Criteria:
- Current or past substance use disorder other than alcohol; excluding caffeine and nicotine
- Psychiatric disorders except for mood and anxiety disorders
- Any significant current medical conditions
- Women who are peri- and post- menopausal, pregnant or lactating
- MRI specific exclusion criteria (e.g., claustrophobia, implanted metal in the body)
