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Neurobiological Responses in Alcoholism and Early Trauma

  • Study HIC#:2000024809
  • Last Updated:07/15/2021

Early trauma is associated with clinical challenges in treatment alcoholism, including complex clinical symptoms and higher relapse rates. To better understand this phenomena, this study will examine the neurobiological mechanisms underlying alcoholism, early trauma, and high relapse risk. The current study utilizes a multimodal neuroimaging technique combining brain and hypothalamic-pituitary-adrenal axis (HPA) measures in a prospective clinical outcome design.

  • Age21 years - 55 years
  • GenderBoth
  • Start Date02/04/2020
  • End Date06/30/2024

Trial Purpose and Description

The current research proposes to investigate neurobiological mechanisms of comorbid AUD and ET and their prospective prediction of alcohol relapse using a multimodal neuroimaging technique that combines functional magnetic resonance imaging (fMRI) and HPA axis measures. 

Eligibility Criteria


AUD inclusion Criteria:

  • Alcohol use disorder
  • Either low or high early trauma (based on the Childhood Trauma Questionnaire)
  • Body mass index (BMI) up to 35 (due to weight limitations of the MRI scanner)

AUD exclusion Criteria:

  • Current or past substance use disorder other than alcohol; excluding caffeine and nicotine
  • Psychiatric disorders except for mood and anxiety disorders
  • Any significant current medical conditions
  • Women who are peri- and post- menopausal, pregnant or lactating
  • MRI specific exclusion criteria (e.g., claustrophobia, implanted metal in the body)

Principal Investigator


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