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Multi-Level Mechanisms and Predictors of Chronic Irritability

  • Study HIC#:2000038262
  • Last Updated:07/08/2025
    The purpose of this study is to look at (1) how children and adolescents' brain responses are related to their irritability trajectories, (2) if the brain responses can predict irritability trajectory and related behaviors one year and two years later, (3) how social and environmental factors are related to chronic irritability, and (4) whether integrating multiple factors enhances the prediction of chronic irritability. The knowledge gained from this study will improve our understanding of childhood irritability trajectories and help guide the development of effective treatment for children and adolescents with chronic irritability.

    Contact Us

    For more information about this study, including how to volunteer, contact:

    Affective Youth Lab

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    You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact helpusdiscover@yale.edu, or call +18779788343 for more information.

    Eligibility Criteria

      Children who are 8-13 years old; all races and ethnicities; no major medical conditions; can undergo an MRI scan; English speaking; no psychiatric diagnoses of the following: autism, bipolar disorder, PTSA, schizophrenia.

    Principal Investigator

    Sub-Investigator

    For more information about this study, including how to volunteer, contact:

    Affective Youth Lab