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Impact of Hypoglycemia on Brain Ketone and Neurotransmitter Metabolism in Type 1 DM

  • Study HIC#:1208010648
  • Last Updated:11/11/2022

This study is being done to look at brain metabolite concentrations under normal and low blood sugar conditions. In addition, we will determine how your brain is able to use ketone bodies as an energy source.

  • Age18 years and older
  • GenderBoth
  • Start Date09/29/2012
  • End Date09/29/2022

Trial Purpose and Description

To determine the long-term effect of severe antecedent hypoglycemia in T1DM pateints on brain energy subtrate metabolism, in particular ketone body metabolism

Eligibility Criteria

Inclusion criteria:

Group 1: 

  • Type 1 diabetes of > 5 years 
  • C-peptide negative 
  • Age 18-60 years 
  • On intensive insulin therapy 
  • HbA1c <7.5% 

Group 2: 

  • Non-diabetic 
  • Age 18-65 years

Exclusion criteria:

  • Pregnancy
  • Significant baseline anemia (hemoglobin <11.0 or hematocrit <33%)
  • A history of liver cirrhosis or porto-caval shunt surgery 
  • Any contraindications for MRI scanning, including presence of metallic implants or claustrophobia 
  • Vegetarian diet
  • Heavy exercise on a regular basis (i.e. marathon runners)
  • Subjects with a history of anxiety/panic attacks 


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