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Impact of Hypoglycemia on Brain Ketone and Neurotransmitter Metabolism in Type 1 DM

  • Study HIC#:1208010648
  • Last Updated:02/02/2024

This study is being done to look at brain metabolite concentrations under normal and low blood sugar conditions. In addition, we will determine how your brain is able to use ketone bodies as an energy source.

  • Age18 years and older
  • GenderBoth

Contact Us

For more information about this study, including how to volunteer, contact:

C. Alice Hahn

Help Us Discover!

You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact, or call +18779788343 for more information.

Trial Purpose and Description

To determine the long-term effect of severe antecedent hypoglycemia in T1DM pateints on brain energy subtrate metabolism, in particular ketone body metabolism

Eligibility Criteria

Inclusion criteria:

Group 1: 

  • Type 1 diabetes of > 5 years 
  • C-peptide negative 
  • Age 18-60 years 
  • On intensive insulin therapy 
  • HbA1c <7.5% 

Group 2: 

  • Non-diabetic 
  • Age 18-65 years

Exclusion criteria:

  • Pregnancy
  • Significant baseline anemia (hemoglobin <11.0 or hematocrit <33%)
  • A history of liver cirrhosis or porto-caval shunt surgery 
  • Any contraindications for MRI scanning, including presence of metallic implants or claustrophobia 
  • Vegetarian diet
  • Heavy exercise on a regular basis (i.e. marathon runners)
  • Subjects with a history of anxiety/panic attacks 

Principal Investigator


For more information about this study, including how to volunteer, contact: