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Imaging smoking-induced dopamine release utilizing PET imaging and nicotine patches

  • Study HIC#:2000023239
  • Last Updated:07/15/2021

You are invited to take part in a research study designed to look at dopamine activation while smoking a cigarette. Men and women experience smoking differently and some medications for smoking cessation work better in men than in women.  We will use PET imaging to identify differences in brain activation between men and women while they are smoking a cigarette (in the PET scanner.) After agreeing to participate in this research, you may be asked to undergo a two-week treatment (of nicotine patches), and up to two PET scans and one MRI scan.

  • Age18 years - 55 years
  • GenderBoth
  • Start Date11/30/2018
  • End Date05/31/2023

Trial Purpose and Description

Our project will investigate the neurochemical basis behind why men and women respond differently to smoking cessation therapy, specifically, to Nicotine Replacement Therapy (NRT). We will utilize PET imaging and mathematical analysis to image and model dopamine release due to cigarette smoking.

Eligibility Criteria

Eligibility criteria

 Tobacco smokers who are otherwise medically healthy, ages 18-55.


Principal Investigator


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