CHIRP (Childhood Host Immune Response Biorepository Program)
- Study HIC#:2000037727
- Last Updated:11/21/2025
If you or your child have any immune dysregulation (such as an autoimmune disease or history of severe infection), you /your child may be eligible to participate in a free and confidential research study investigating how the immune system changes during childhood and how to improve immune responses to prevent and limit severity of infections and other diseases. We will be collecting samples such as blood, nasal swab, saliva, respiratory aspirate (only in patients requiring invasive mechanical ventilation), left over clinical and pathology specimens, and stool samples to create a repository to study immune diseases.
Contact Us
For more information about this study, including how to volunteer, contact:
Nina Brodsky
Help Us Discover!
You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact helpusdiscover@yale.edu, or call +18779788343 for more information.
Trial Purpose and Description
This is a bio-specimen analysis that will examine developmental immune responses throughout the lifespan (from neontates, infants, children, to their parents and young adults). The primary objective is to collect a biorepository of specimens for the purpose of characterizing and understanding developmentally programmed functions of immune cells in the blood, lung, and other tissues from individuals during health and immune mediated illness throughout development. We will use molecular biology, genetic, and omic techniques including spectral flow cytometry, mass cytometry, RNA and genomic sequencing.
Eligibility Criteria
Healthy controls: Male or female ≥ 0 years of age who have no diseases of the immune system such as autoimmunity, inflammatory disease, severe infections.
Patients: Male or female ≥ 0 years of age who are affected with an illness involving immune dysregulation.
