DMT and Mental Health Study
- Study IRB#:2000034770
- Last Updated:10/28/2026
Adults diagnosed with Major Depressive Disorder who are currently experiencing moderate to severe depression. People who have tried at least one antidepressant without enough improvement, or who couldn’t tolerate the medication.
Must be seeing a clinician for depression (or be willing to start treatment before joining the study). Willing to let the research team communicate with your primary mental health provider during the study.
- Age21 years - 65 years
- GenderBoth
Contact Us
For more information about this study, including how to volunteer, contact:
Prakash Gupta, MD. Phone ext. 14495
- Phone Number: 203-932-5711 x14495
Help Us Discover!
You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact helpusdiscover@yale.edu, or call 877-978-8343 for more information.
Study Location
- Yale University
Eligibility Criteria
Eligibility Criteria
This study is testing the safety and effects of DMT, a psychedelic found in the traditional brew Ayahuasca. We are looking at how DMT affects the brain and whether it may help people with depression. The study includes both healthy volunteers and individuals living with depression.
Ages: 21 to 65
Study involves:
- Screening visits
- 2 out patient dosing sessions
- 4 outpatient follow up visits
- 5 EEG sessions and weekly follow up visits over 12 weeks.
Pays up to: $750
