Psychedelics Research Study with DMT in Adults Aged 21 to 65 with Major Depression.

Inclusion Criteria for Subjects with Major Depressive Disorder

1. Diagnosed with Major Depressive Disorder (MDD), single or recurrent episode, and currently experiencing a Major Depressive Episode (MDE), of a moderate to severe degree
2. Unsatisfactory response to at least one adequate antidepressant trial (at least 6 weeks on a therapeutic dose) during the current depressive episode and/or unable to tolerate existing antidepressants confirmed with the primary mental health provider
3. Engaged in treatment for depression with a clinician and willing to continue treatment for the duration of the study;
4. Those not engaged in treatment at the time of screening will be required to engage in treatment as a condition of study participation.
5. Consent to allow the research team to engage the primary mental health provider.

Inclusion Criteria for Healthy Adults

1. Males and females, age 21 to 65 years;
2. Body mass index between 18-35 kg/m2;
3. English speaking
4. Willing to refrain from taking any medications not approved by the study physician;
5. Willing to refrain from using street drugs and alcohol the day before, the day of, and the day after each test session;
6. Negative urine drug screen on the morning of each test session (the following drugs will be tested for: cocaine, opioids, benzodiazepines, cannabinoids, stimulants);
7. Willing and able to abstain from smoking throughout each test session;
8. Women who are of child-bearing potential and sexually active must be willing to practice an effective means of birth control;
9. Willing not to drive to and from the testing session.