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Phase Pilot

Brain Imaging and Synaptic Plasticity

  • Study HIC#:2000029552
  • Last Updated:11/29/2023

Are you between 21 and 60 years old?

Do you currently use cocaine?

You may be eligible to participate in 3-week paid brain imaging inpatient study plus outpatient follow-ups. This is not a treatment study. Compensation up to $2,500

We are also seeking healthy controls aged 21-60 years old for outpatient brain imaging and computer tasks. Compensation up to $750.

For more information email  or call our recruitment line at (203) 903-7795 and leave a message.

  • Age21 years - 60 years
  • GenderBoth

Contact Us

For more information about this study, including how to volunteer, contact:

CNRU Studies Recruitment

Help Us Discover!

You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact, or call +18779788343 for more information.

Trial Purpose and Description

The purpose of this research study is to measure synaptic density in the brain comparing individuals with cocaine use disorder to healthy controls.

Eligibility Criteria

One group will have current Cocaine Use Disorder, the other group will be Healthy Controls


Inclusion Criteria:

  • Age 21-60 years
  • Physically healthy by medical history, physical, neurological, ECG and laboratory examinations
  • For females, a negative serum pregnancy test
  • For CUD: DSM-5 criteria for Cocaine Use Disorder and positive urine toxicology showing recent use
  • For HC: Negative urine toxicology

Exclusion Criteria:

  • DSM-5 criteria for other substance use disorders (e.g., alcohol, opiates, sedative hypnotics), except for nicotine
  • A primary DSM-5 Axis I major psychiatric disorder (e.g., schizophrenia, bipolar disorder, major depression, etc.) as determined by the Structured Clinical Interview for DSM-5 (SCID-5)
  • A history of significant and/or uncontrolled medical or neurological illness
  • Current use of psychotropic and/or potentially psychoactive prescription medications
  • Medical contraindications to MRI procedure

Principal Investigator

For more information about this study, including how to volunteer, contact:

CNRU Studies Recruitment