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Minimal Change Disease

Definition

Minimal change disease (MCD) is a kidney disorder characterized by damage to the glomeruli, the tiny blood vessels in the kidneys responsible for filtering waste and excess water from the blood. In MCD, the glomeruli appear normal under a regular microscope but show changes when examined with an electron microscope. This condition often leads to nephrotic syndrome, causing proteinuria, edema, and hypoalbuminemia.