Won Jae Huh, MD, PhD
Pathology, GI & Liver Pathology
Titles
- Assistant Professor of Pathology
Education & Training
- Postdoctoral fellowshipVanderbilt University Medical Center
- Fellowship in GI/Liver PathologyVanderbilt University Medical Center (2016)
- Residency in Anatomic PathologyMontefiore Medical Center/Albert Einstein College of Medicine (2014)
- PhDWashington University in St. Louis, Developmental Biology (2010)
- BSKorea National Open University, Information Statistics
- MDSeoul National University College of Medicine (2002)
Languages Spoken
- English
- 한국어 (Korean)
Additional Information
Board Certifications
- AB of Pathology, Anatomic Pathology (2014)
Publications
- Kim S, Adams T, Hu Q, Shin H, Chae G, Lee S, Sharma L, Kwon H, Lee F, Park H, Huh W, Manning E, Kaminski N, Sauler M, Chen L, Song J, Kim T, Kang M. VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2023, 69: 22-33. PMID: 36450109, PMCID: PMC10324045, DOI: 10.1165/rcmb.2022-0219oc.
- Willet S, Thanintorn N, McNeill H, Huh S, Ornitz D, Huh W, Hoft S, DiPaolo R, Mills J. SOX9 Governs Gastric Mucous Neck Cell Identity and Is Required for Injury-Induced Metaplasia. Cellular And Molecular Gastroenterology And Hepatology 2023, 16: 325-339. PMID: 37270061, PMCID: PMC10444955, DOI: 10.1016/j.jcmgh.2023.05.009.
- Gabriel T, Coffey R, Huh W. 126 EGFR SIGNALING IN GASTRIC CHIEF CELL IS NECESSARY FOR THE PATHOGENESIS OF MÉNÉTRIER'S DISEASE VIA NOTCH SIGNALING ACTIVATION. Gastroenterology 2023, 164: s-22. DOI: 10.1016/s0016-5085(23)01006-5.
- Shin M, Ramirez M, Liu Q, Coffey R, Huh W. Mo1222 HES1 IS A NOVEL MARKER THAT CAN DISTINGUISH MÉNÉTRIER'S DISEASE FROM JUVENILE POLYPOSIS SYNDROME. Gastroenterology 2023, 164: s-790. DOI: 10.1016/s0016-5085(23)02828-7.
- Mede A, Chotai P, Huh W, Tan M. Intra-Abdominal Cystic Lymphangiomas: The Vanderbilt Experience. Journal Of Surgical Research 2023, 285: 197-204. PMID: 36696706, DOI: 10.1016/j.jss.2022.12.026.
- Hu Q, Hedgepath C, Hong J, Huh W, Han X, Vesely M, Chen L, Kim T. PD-1H/VISTA expressed on host myeloid cells regulates acute graft-versus-host disease (aGVHD). The Journal Of Immunology 2022, 208: 175.06-175.06. DOI: 10.4049/jimmunol.208.supp.175.06.
- Markham N, Drewes J, Domingue J, Chen B, Heiser C, Bingham M, Simmons A, Ramirez M, Kotrannavar S, Lunnemann H, Laubacher E, Huh W, Shrubsole M, Liu Q, Coffey R, Sears C, Lau K. Sa1113: A SINGLE-CELL RESOLUTION, MULTI-OMIC SPATIAL ATLAS OF COLONIC TUMORIGENESIS DRIVEN BY C. DIFFICILE FROM HUMAN COLORECTAL CANCER-ASSOCIATED BIOFILMS. Gastroenterology 2022, 162: s-310-s-311. DOI: 10.1016/s0016-5085(22)60740-6.
- Huh W, Alexopoulos S, Coffey R. Mo1343: TESTOSTERONE-DEPENDENT DIFFERENTIAL EXPRESSION OF EGFR IN MALE AND FEMALE LIVERS AND ITS IMPLICATIONS FOR CARCINOGENESIS. Gastroenterology 2022, 162: s-1225. DOI: 10.1016/s0016-5085(22)63622-9.
- Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M, Chen JH, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS. Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell 2021, 184: 6262-6280.e26. PMID: 34910928, PMCID: PMC8941949, DOI: 10.1016/j.cell.2021.11.031.
- Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ. Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets. Nature Cell Biology 2021, 23: 1240-1254. PMID: 34887515, PMCID: PMC8656144, DOI: 10.1038/s41556-021-00805-8.
- Niitsu H, Lu Y, Huh W, Love A, Franklin J, Coffey R. Cell-Autonomous Role of EGFR in Spontaneous Duodenal Tumors in LRIG1 Null Mice. Cellular And Molecular Gastroenterology And Hepatology 2021, 12: 1159-1162.e4. PMID: 33989815, PMCID: PMC8413138, DOI: 10.1016/j.jcmgh.2021.05.004.
- Markham N, Drewes J, Domingue J, Chen B, Heiser C, Bingham M, Simmons A, Southard-Smith A, Macedonia M, Ramirez M, Laubacher E, Huh W, Shrubsole M, Liu Q, Coffey R, Sears C, Lau K. 665 HUMAN COLON CANCER-ASSOCIATED BIOFILMS ALTER HOST IMMUNE POPULATIONS AND PROMOTE TUMORIGENESIS. Gastroenterology 2021, 160: s-128. DOI: 10.1016/s0016-5085(21)01059-3.
- Kondo J, Huh WJ, Franklin JL, Heinrich MC, Rubin BP, Coffey RJ. A smooth muscle‐derived, Braf‐driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell‐of‐origin. The Journal Of Pathology 2020, 252: 441-450. PMID: 32944951, PMCID: PMC7802691, DOI: 10.1002/path.5552.
- Liang J, Shi C, Dupont WD, Salaria SN, Huh WJ, Correa H, Roland JT, Perri RE, Washington MK. Key histopathologic features in idiopathic noncirrhotic portal hypertension: an interobserver agreement study and proposal for diagnostic criteria. Modern Pathology 2020, 34: 592-602. PMID: 32958831, DOI: 10.1038/s41379-020-00676-8.
- Coffey R, Niitsu H, Lu Y, Huh W, Franklin J. Abstract 1624: Lrig1 is an Egfr-dependent tumor suppressor in mouse duodenal and colonic neoplasia. Cancer Research 2020, 80: 1624-1624. DOI: 10.1158/1538-7445.am2020-1624.
- Pinzon-Guzman C, Sangadala S, Riera KM, Popova EY, Manning E, Huh WJ, Alexander MS, Shelton JS, Boden SD, Goldenring JR. Noggin regulates foregut progenitor cell programming and mis-expression leads to esophageal atresia. Journal Of Clinical Investigation 2020, 130: 4396-4410. PMID: 32427591, PMCID: PMC7410075, DOI: 10.1172/jci123597.
- Huh W, Roland J, Asai M, kaji I. Tu1191 DISTRIBUTION OF DUODENAL TUFT CELLS IS ALTERED IN PEDIATRIC PATIENTS WITH ACUTE AND CHRONIC ENTEROPATHY. Gastroenterology 2020, 158: s-1013. DOI: 10.1016/s0016-5085(20)33202-9.
- Rezanejad S, Ramirez M, Liu Q, Coffey R, Huh W. Tu1204 BETTER UNDERSTANDING OF MENETRIER'S DISEASE ANDJUVENILE POLYPOSIS SYNDROME BY RNA SEQUENCING. Gastroenterology 2020, 158: s-1017-s-1018. DOI: 10.1016/s0016-5085(20)33215-7.
- Rozenblatt-Rosen O, Regev A, Oberdoerffer P, Nawy T, Hupalowska A, Rood J, Ashenberg O, Cerami E, Coffey R, Demir E, Ding L, Esplin E, Ford J, Goecks J, Ghosh S, Gray J, Guinney J, Hanlon S, Hughes S, Hwang E, Iacobuzio-Donahue C, Jané-Valbuena J, Johnson B, Lau K, Lively T, Mazzilli S, Pe’er D, Santagata S, Shalek A, Schapiro D, Snyder M, Sorger P, Spira A, Srivastava S, Tan K, West R, Williams E, Network H, Aberle D, Achilefu S, Ademuyiwa F, Adey A, Aft R, Agarwal R, Aguilar R, Alikarami F, Allaj V, Amos C, Anders R, Angelo M, Anton K, Ashenberg O, Aster J, Babur O, Bahmani A, Balsubramani A, Barrett D, Beane J, Bender D, Bernt K, Berry L, Betts C, Bletz J, Blise K, Boire A, Boland G, Borowsky A, Bosse K, Bott M, Boyden E, Brooks J, Bueno R, Burlingame E, Cai Q, Campbell J, Caravan W, Cerami E, Chaib H, Chan J, Chang Y, Chatterjee D, Chaudhary O, Chen A, Chen B, Chen C, Chen C, Chen F, Chen Y, Chheda M, Chin K, Chiu R, Chu S, Chuaqui R, Chun J, Cisneros L, Coffey R, Colditz G, Cole K, Collins N, Contrepois K, Coussens L, Creason A, Crichton D, Curtis C, Davidsen T, Davies S, de Bruijn I, Dellostritto L, De Marzo A, Demir E, DeNardo D, Diep D, Ding L, Diskin S, Doan X, Drewes J, Dubinett S, Dyer M, Egger J, Eng J, Engelhardt B, Erwin G, Esplin E, Esserman L, Felmeister A, Feiler H, Fields R, Fisher S, Flaherty K, Flournoy J, Ford J, Fortunato A, Frangieh A, Frye J, Fulton R, Galipeau D, Gan S, Gao J, Gao L, Gao P, Gao V, Geiger T, George A, Getz G, Ghosh S, Giannakis M, Gibbs D, Gillanders W, Goecks J, Goedegebuure S, Gould A, Gowers K, Gray J, Greenleaf W, Gresham J, Guerriero J, Guha T, Guimaraes A, Guinney J, Gutman D, Hacohen N, Hanlon S, Hansen C, Harismendy O, Harris K, Hata A, Hayashi A, Heiser C, Helvie K, Herndon J, Hirst G, Hodi F, Hollmann T, Horning A, Hsieh J, Hughes S, Huh W, Hunger S, Hwang S, Iacobuzio-Donahue C, Ijaz H, Izar B, Jacobson C, Janes S, Jané-Valbuena J, Jayasinghe R, Jiang L, Johnson B, Johnson B, Ju T, Kadara H, Kaestner K, Kagan J, Kalinke L, Keith R, Khan A, Kibbe W, Kim A, Kim E, Kim J, Kolodzie A, Kopytra M, Kotler E, Krueger R, Krysan K, Kundaje A, Ladabaum U, Lake B, Lam H, Laquindanum R, Lau K, Laughney A, Lee H, Lenburg M, Leonard C, Leshchiner I, Levy R, Li J, Lian C, Lim K, Lin J, Lin Y, Liu Q, Liu R, Lively T, Longabaugh W, Longacre T, X. C, Macedonia M, Madison T, Maher C, Maitra A, Makinen N, Makowski D, Maley C, Maliga Z, Mallo D, Maris J, Markham N, Marks J, Martinez D, Mashl R, Masilionais I, Mason J, Massagué J, Massion P, Mattar M, Mazurchuk R, Mazutis L, Mazzilli S, McKinley E, McMichael J, Merrick D, Meyerson M, Miessner J, Mills G, Mills M, Mondal S, Mori M, Mori Y, Moses E, Mosse Y, Muhlich J, Murphy G, Navin N, Nawy T, Nederlof M, Ness R, Nevins S, Nikolov M, Nirmal A, Nolan G, Novikov E, Oberdoerffer P, O’Connell B, Offin M, Oh S, Olson A, Ooms A, Ossandon M, Owzar K, Parmar S, Patel T, Patti G, Pe’er D, Pe'er I, Peng T, Persson D, Petty M, Pfister H, Polyak K, Pourfarhangi K, Puram S, Qiu Q, Quintanal-Villalonga Á, Raj A, Ramirez-Solano M, Rashid R, Reeb A, Regev A, Reid M, Resnick A, Reynolds S, Riesterer J, Rodig S, Roland J, Rosenfield S, Rotem A, Roy S, Rozenblatt-Rosen O, Rudin C, Ryser M, Santagata S, Santi-Vicini M, Sato K, Schapiro D, Schrag D, Schultz N, Sears C, Sears R, Sen S, Sen T, Shalek A, Sheng J, Sheng Q, Shoghi K, Shrubsole M, Shyr Y, Sibley A, Siex K, Simmons A, Singer D, Sivagnanam S, Slyper M, Snyder M, Sokolov A, Song S, Sorger P, Southard-Smith A, Spira A, Srivastava S, Stein J, Storm P, Stover E, Strand S, Su T, Sudar D, Sullivan R, Surrey L, Suvà M, Tan K, Terekhanova N, Ternes L, Thammavong L, Thibault G, Thomas G, Thorsson V, Todres E, Tran L, Tyler M, Uzun Y, Vachani A, Van Allen E, Vandekar S, Veis D, Vigneau S, Vossough A, Waanders A, Wagle N, Wang L, Wendl M, West R, Williams E, Wu C, Wu H, Wu H, Wyczalkowski M, Xie Y, Yang X, Yapp C, Yu W, Yuan Y, Zhang D, Zhang K, Zhang M, Zhang N, Zhang Y, Zhao Y, Zhou D, Zhou Z, Zhu H, Zhu Q, Zhu X, Zhu Y, Zhuang X. The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution. Cell 2020, 181: 236-249. PMID: 32302568, PMCID: PMC7376497, DOI: 10.1016/j.cell.2020.03.053.
- Jae Huh W, Niitsu H, Carney B, McKinley ET, Houghton JL, Coffey RJ. Identification and Characterization of Unique Neutralizing Antibodies to Mouse EGF Receptor. Gastroenterology 2020, 158: 1500-1502. PMID: 31866246, PMCID: PMC7103561, DOI: 10.1053/j.gastro.2019.12.017.
- Huh WJ, Roland JT, Asai M, Kaji I. Distribution of duodenal tuft cells is altered in pediatric patients with acute and chronic enteropathy. Biomedical Research 2020, 41: 113-118. PMID: 32307399, PMCID: PMC10037909, DOI: 10.2220/biomedres.41.113.
- Byrd KM, Piehl NC, Patel JH, Huh WJ, Sequeira I, Lough KJ, Wagner BL, Marangoni P, Watt FM, Klein OD, Coffey RJ, Williams SE. Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress. Cell Stem Cell 2019, 25: 814-829.e6. PMID: 31809739, PMCID: PMC6925542, DOI: 10.1016/j.stem.2019.11.005.
- Ajayi T, Dawodu E, Huh W, Scanga A, Izzy M. 2357 Drug-Induced Liver Injury (DILI) Does Not Always Follow the Textbook. The American Journal Of Gastroenterology 2019, 114: s1312-s1313. DOI: 10.14309/01.ajg.0000598960.07963.76.
- Markham N, Cao Z, Kasturi S, Fry W, Huh W, Coffey R. Sa1117 – Tnks2 Promotes Wnt/Β-Catenin Signaling Through Degredation of Nkd2 in Colon Cancer Cells. Gastroenterology 2019, 156: s-275. DOI: 10.1016/s0016-5085(19)37500-6.
- Huh W, Niitsu H, McKinley E, Carney B, Houghton J, Coffey R. Sa1741 – Identification and Characterization of the First Neutralizing Antibody to Mouse Egfr. Gastroenterology 2019, 156: s-383. DOI: 10.1016/s0016-5085(19)37808-4.
- Markham NO, Huh WJ, Coffey RJ. Linking ALDH1 and retinoic acid signaling. Oncotarget 2019, 10: 1226-1227. PMID: 30815222, PMCID: PMC6383818, DOI: 10.18632/oncotarget.26661.
- Huh W, Coffey R. Abstract A34: EGF receptor-activated Notch signaling contributes to pathogenesis of premalignant gastric lesions. Cancer Research 2018, 78: a34-a34. DOI: 10.1158/1538-7445.mousemodels17-a34.
- Huh W, Rhoades K, Coffey R. Sa1629 - Testosterone-Dependent Differential Expression of Egfr in Male and Female Mice and Its Implications for Carcinogenesis and Treatment Response. Gastroenterology 2018, 154: s-333-s-334. DOI: 10.1016/s0016-5085(18)31453-7.
- Markham N, Fry W, Cao Z, Huh W, Coffey R. Su2036 - TNKS2 Promotes WNT/β-Catenin Signaling through Parylation of NKD2 in Colon Cancer Cells. Gastroenterology 2018, 154: s-1365. DOI: 10.1016/s0016-5085(18)34460-3.
- Yang YP, Ma H, Starchenko A, Huh WJ, Li W, Hickman FE, Zhang Q, Franklin JL, Mortlock DP, Fuhrmann S, Carter BD, Ihrie RA, Coffey RJ. A Chimeric Egfr Protein Reporter Mouse Reveals Egfr Localization and Trafficking In Vivo. Cell Reports 2017, 19: 1257-1267. PMID: 28494873, PMCID: PMC5517093, DOI: 10.1016/j.celrep.2017.04.048.
- Huh W, Coffey R. 987 EGFR-Activated Notch Signaling Contributes to Pathogenesis of Ménétrier's Disease. Gastroenterology 2017, 152: s187. DOI: 10.1016/s0016-5085(17)30936-8.
- Charoenpitakchai M, Liu E, Zhao Z, Koyama T, Huh WJ, Berlin J, Hande K, Walker R, Shi C. In liver metastases from small intestinal neuroendocrine tumors, SSTR2A expression is heterogeneous. Virchows Archiv 2017, 470: 545-552. PMID: 28213807, PMCID: PMC5623953, DOI: 10.1007/s00428-017-2093-3.
- Gonzalez RS, Huh WJ, Cates JM, Washington K, Beauchamp RD, Coffey RJ, Shi C. Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial–mesenchymal transition. Histopathology 2016, 70: 223-231. PMID: 27560620, PMCID: PMC5921077, DOI: 10.1111/his.13068.
- Gonzalez RS, Gilger MA, Huh WJ, Washington MK. The Spectrum of Histologic Findings in Hepatic Outflow Obstruction. Archives Of Pathology & Laboratory Medicine 2016, 141: 98-103. PMID: 27681331, PMCID: PMC6420777, DOI: 10.5858/arpa.2015-0388-oa.
- Moore BD, Khurana SS, Huh WJ, Mills JC. Hepatocyte nuclear factor 4α is required for cell differentiation and homeostasis in the adult mouse gastric epithelium. AJP Gastrointestinal And Liver Physiology 2016, 311: g267-g275. PMID: 27340127, PMCID: PMC5007292, DOI: 10.1152/ajpgi.00195.2016.
- Huh WJ, Coffey RJ, Washington MK. Ménétrier’s Disease: Its Mimickers and Pathogenesis. Journal Of Pathology And Translational Medicine 2015, 50: 10-16. PMID: 26689786, PMCID: PMC4734964, DOI: 10.4132/jptm.2015.09.15.
- Moon CM, Kim SH, Lee SK, Hyeon J, Koo JS, Lee S, Wang JS, Huh WJ, Khurana SS, Mills JC. Chronic Tamoxifen Use Is Associated with a Decreased Risk of Intestinal Metaplasia in Human Gastric Epithelium. Digestive Diseases And Sciences 2013, 59: 1244-1254. PMID: 24368421, PMCID: PMC4035390, DOI: 10.1007/s10620-013-2994-1.
- Evolution of the human gastrokine locus and confounding factors regarding the pseudogenicity of GKN3Geahlen JH, Lapid C, Thorell K, Nikolskiy I, Huh WJ, Oates EL, Lennerz JK, Tian X, Weis VG, Khurana SS, Lundin SB, Templeton AR, Mills JC. Evolution of the human gastrokine locus and confounding factors regarding the pseudogenicity of GKN3. Physiological Genomics 2013, 45: 667-683. PMID: 23715263, PMCID: PMC3742967, DOI: 10.1152/physiolgenomics.00169.2012.
- Huh W, Albanese J, Salavaggione L, Liu Q, Neuschwander-Tetri B, Brunt E. 804 Hepatic Zonation in a Nonalcoholic Steatohepatitis Mouse Model. Gastroenterology 2013, 144: s-963. DOI: 10.1016/s0016-5085(13)63578-7.
- Khurana S, Huh W, Moore B, Riehl T, Stenson W, Mills J. The presumptive gastric corpus stem cell population is CD44‐positive and expands during metaplasia via increased ERK‐MAPK signaling. The FASEB Journal 2012, 26: 1160.3-1160.3. DOI: 10.1096/fasebj.26.1_supplement.1160.3.
- Huh WJ, Khurana SS, Geahlen JH, Kohli K, Waller RA, Mills JC. Tamoxifen Induces Rapid, Reversible Atrophy, and Metaplasia in Mouse Stomach. Gastroenterology 2011, 142: 21-24.e7. PMID: 22001866, PMCID: PMC3708546, DOI: 10.1053/j.gastro.2011.09.050.
- Huh WJ, Esen E, Geahlen JH, Bredemeyer AJ, Lee A, Shi G, Konieczny SF, Glimcher LH, Mills JC. XBP1 Controls Maturation of Gastric Zymogenic Cells by Induction of MIST1 and Expansion of the Rough Endoplasmic Reticulum. Gastroenterology 2010, 139: 2038-2049. PMID: 20816838, PMCID: PMC2997137, DOI: 10.1053/j.gastro.2010.08.050.
- Lennerz JK, Kim SH, Oates EL, Huh WJ, Doherty JM, Tian X, Bredemeyer AJ, Goldenring JR, Lauwers GY, Shin YK, Mills JC. The Transcription Factor MIST1 Is a Novel Human Gastric Chief Cell Marker Whose Expression Is Lost in Metaplasia, Dysplasia, and Carcinoma. American Journal Of Pathology 2010, 177: 1514-1533. PMID: 20709804, PMCID: PMC2928982, DOI: 10.2353/ajpath.2010.100328.
- Huh WJ, Mysorekar IU, Mills JC. Inducible activation of Cre recombinase in adult mice causes gastric epithelial atrophy, metaplasia, and regenerative changes in the absence of “floxed” alleles. AJP Gastrointestinal And Liver Physiology 2010, 299: g368-g380. PMID: 20413717, PMCID: PMC3774481, DOI: 10.1152/ajpgi.00021.2010.
- Huh W, Esen E, Bredemeyer A, Shi G, Lee A, Konieczny S, Glimcher L, Mills J. 863 XBP1 Is Required for the Maturation and the Maintenance of Digestive-Enzyme Secreting Zymogenic (Chief) Cells. Gastroenterology 2009, 136: a-132. DOI: 10.1016/s0016-5085(09)60592-8.
- Capoccia BJ, Huh WJ, Mills JC. How form follows functional genomics: gene expression profiling gastric epithelial cells with a particular discourse on the parietal cell. Physiological Genomics 2009, 37: 67-78. PMID: 19208773, PMCID: PMC2685495, DOI: 10.1152/physiolgenomics.90408.2008.
- Bredemeyer AJ, Geahlen JH, Weis VG, Huh WJ, Zinselmeyer BH, Srivatsan S, Miller MJ, Shaw AS, Mills JC. The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage. Developmental Biology 2008, 325: 211-224. PMID: 19013146, PMCID: PMC2634829, DOI: 10.1016/j.ydbio.2008.10.025.
- Huh WJ, Pan XO, Mysorekar IU, Mills JC. Location, allocation, relocation: isolating adult tissue stem cells in three dimensions. Current Opinion In Biotechnology 2006, 17: 511-517. PMID: 16889955, DOI: 10.1016/j.copbio.2006.07.002.
Departments and Programs
Titles
- Assistant Professor of Pathology
Education & Training
- Postdoctoral fellowshipVanderbilt University Medical Center
- Fellowship in GI/Liver PathologyVanderbilt University Medical Center (2016)
- Residency in Anatomic PathologyMontefiore Medical Center/Albert Einstein College of Medicine (2014)
- PhDWashington University in St. Louis, Developmental Biology (2010)
- BSKorea National Open University, Information Statistics
- MDSeoul National University College of Medicine (2002)
Languages Spoken
- English
- 한국어 (Korean)
Additional Information
Board Certifications
- AB of Pathology, Anatomic Pathology (2014)
Publications
- Kim S, Adams T, Hu Q, Shin H, Chae G, Lee S, Sharma L, Kwon H, Lee F, Park H, Huh W, Manning E, Kaminski N, Sauler M, Chen L, Song J, Kim T, Kang M. VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2023, 69: 22-33. PMID: 36450109, PMCID: PMC10324045, DOI: 10.1165/rcmb.2022-0219oc.
- Willet S, Thanintorn N, McNeill H, Huh S, Ornitz D, Huh W, Hoft S, DiPaolo R, Mills J. SOX9 Governs Gastric Mucous Neck Cell Identity and Is Required for Injury-Induced Metaplasia. Cellular And Molecular Gastroenterology And Hepatology 2023, 16: 325-339. PMID: 37270061, PMCID: PMC10444955, DOI: 10.1016/j.jcmgh.2023.05.009.
- Gabriel T, Coffey R, Huh W. 126 EGFR SIGNALING IN GASTRIC CHIEF CELL IS NECESSARY FOR THE PATHOGENESIS OF MÉNÉTRIER'S DISEASE VIA NOTCH SIGNALING ACTIVATION. Gastroenterology 2023, 164: s-22. DOI: 10.1016/s0016-5085(23)01006-5.
- Shin M, Ramirez M, Liu Q, Coffey R, Huh W. Mo1222 HES1 IS A NOVEL MARKER THAT CAN DISTINGUISH MÉNÉTRIER'S DISEASE FROM JUVENILE POLYPOSIS SYNDROME. Gastroenterology 2023, 164: s-790. DOI: 10.1016/s0016-5085(23)02828-7.
- Mede A, Chotai P, Huh W, Tan M. Intra-Abdominal Cystic Lymphangiomas: The Vanderbilt Experience. Journal Of Surgical Research 2023, 285: 197-204. PMID: 36696706, DOI: 10.1016/j.jss.2022.12.026.
- Hu Q, Hedgepath C, Hong J, Huh W, Han X, Vesely M, Chen L, Kim T. PD-1H/VISTA expressed on host myeloid cells regulates acute graft-versus-host disease (aGVHD). The Journal Of Immunology 2022, 208: 175.06-175.06. DOI: 10.4049/jimmunol.208.supp.175.06.
- Markham N, Drewes J, Domingue J, Chen B, Heiser C, Bingham M, Simmons A, Ramirez M, Kotrannavar S, Lunnemann H, Laubacher E, Huh W, Shrubsole M, Liu Q, Coffey R, Sears C, Lau K. Sa1113: A SINGLE-CELL RESOLUTION, MULTI-OMIC SPATIAL ATLAS OF COLONIC TUMORIGENESIS DRIVEN BY C. DIFFICILE FROM HUMAN COLORECTAL CANCER-ASSOCIATED BIOFILMS. Gastroenterology 2022, 162: s-310-s-311. DOI: 10.1016/s0016-5085(22)60740-6.
- Huh W, Alexopoulos S, Coffey R. Mo1343: TESTOSTERONE-DEPENDENT DIFFERENTIAL EXPRESSION OF EGFR IN MALE AND FEMALE LIVERS AND ITS IMPLICATIONS FOR CARCINOGENESIS. Gastroenterology 2022, 162: s-1225. DOI: 10.1016/s0016-5085(22)63622-9.
- Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M, Chen JH, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS. Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell 2021, 184: 6262-6280.e26. PMID: 34910928, PMCID: PMC8941949, DOI: 10.1016/j.cell.2021.11.031.
- Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ. Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets. Nature Cell Biology 2021, 23: 1240-1254. PMID: 34887515, PMCID: PMC8656144, DOI: 10.1038/s41556-021-00805-8.
- Niitsu H, Lu Y, Huh W, Love A, Franklin J, Coffey R. Cell-Autonomous Role of EGFR in Spontaneous Duodenal Tumors in LRIG1 Null Mice. Cellular And Molecular Gastroenterology And Hepatology 2021, 12: 1159-1162.e4. PMID: 33989815, PMCID: PMC8413138, DOI: 10.1016/j.jcmgh.2021.05.004.
- Markham N, Drewes J, Domingue J, Chen B, Heiser C, Bingham M, Simmons A, Southard-Smith A, Macedonia M, Ramirez M, Laubacher E, Huh W, Shrubsole M, Liu Q, Coffey R, Sears C, Lau K. 665 HUMAN COLON CANCER-ASSOCIATED BIOFILMS ALTER HOST IMMUNE POPULATIONS AND PROMOTE TUMORIGENESIS. Gastroenterology 2021, 160: s-128. DOI: 10.1016/s0016-5085(21)01059-3.
- Kondo J, Huh WJ, Franklin JL, Heinrich MC, Rubin BP, Coffey RJ. A smooth muscle‐derived, Braf‐driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell‐of‐origin. The Journal Of Pathology 2020, 252: 441-450. PMID: 32944951, PMCID: PMC7802691, DOI: 10.1002/path.5552.
- Liang J, Shi C, Dupont WD, Salaria SN, Huh WJ, Correa H, Roland JT, Perri RE, Washington MK. Key histopathologic features in idiopathic noncirrhotic portal hypertension: an interobserver agreement study and proposal for diagnostic criteria. Modern Pathology 2020, 34: 592-602. PMID: 32958831, DOI: 10.1038/s41379-020-00676-8.
- Coffey R, Niitsu H, Lu Y, Huh W, Franklin J. Abstract 1624: Lrig1 is an Egfr-dependent tumor suppressor in mouse duodenal and colonic neoplasia. Cancer Research 2020, 80: 1624-1624. DOI: 10.1158/1538-7445.am2020-1624.
- Pinzon-Guzman C, Sangadala S, Riera KM, Popova EY, Manning E, Huh WJ, Alexander MS, Shelton JS, Boden SD, Goldenring JR. Noggin regulates foregut progenitor cell programming and mis-expression leads to esophageal atresia. Journal Of Clinical Investigation 2020, 130: 4396-4410. PMID: 32427591, PMCID: PMC7410075, DOI: 10.1172/jci123597.
- Huh W, Roland J, Asai M, kaji I. Tu1191 DISTRIBUTION OF DUODENAL TUFT CELLS IS ALTERED IN PEDIATRIC PATIENTS WITH ACUTE AND CHRONIC ENTEROPATHY. Gastroenterology 2020, 158: s-1013. DOI: 10.1016/s0016-5085(20)33202-9.
- Rezanejad S, Ramirez M, Liu Q, Coffey R, Huh W. Tu1204 BETTER UNDERSTANDING OF MENETRIER'S DISEASE ANDJUVENILE POLYPOSIS SYNDROME BY RNA SEQUENCING. Gastroenterology 2020, 158: s-1017-s-1018. DOI: 10.1016/s0016-5085(20)33215-7.
- Rozenblatt-Rosen O, Regev A, Oberdoerffer P, Nawy T, Hupalowska A, Rood J, Ashenberg O, Cerami E, Coffey R, Demir E, Ding L, Esplin E, Ford J, Goecks J, Ghosh S, Gray J, Guinney J, Hanlon S, Hughes S, Hwang E, Iacobuzio-Donahue C, Jané-Valbuena J, Johnson B, Lau K, Lively T, Mazzilli S, Pe’er D, Santagata S, Shalek A, Schapiro D, Snyder M, Sorger P, Spira A, Srivastava S, Tan K, West R, Williams E, Network H, Aberle D, Achilefu S, Ademuyiwa F, Adey A, Aft R, Agarwal R, Aguilar R, Alikarami F, Allaj V, Amos C, Anders R, Angelo M, Anton K, Ashenberg O, Aster J, Babur O, Bahmani A, Balsubramani A, Barrett D, Beane J, Bender D, Bernt K, Berry L, Betts C, Bletz J, Blise K, Boire A, Boland G, Borowsky A, Bosse K, Bott M, Boyden E, Brooks J, Bueno R, Burlingame E, Cai Q, Campbell J, Caravan W, Cerami E, Chaib H, Chan J, Chang Y, Chatterjee D, Chaudhary O, Chen A, Chen B, Chen C, Chen C, Chen F, Chen Y, Chheda M, Chin K, Chiu R, Chu S, Chuaqui R, Chun J, Cisneros L, Coffey R, Colditz G, Cole K, Collins N, Contrepois K, Coussens L, Creason A, Crichton D, Curtis C, Davidsen T, Davies S, de Bruijn I, Dellostritto L, De Marzo A, Demir E, DeNardo D, Diep D, Ding L, Diskin S, Doan X, Drewes J, Dubinett S, Dyer M, Egger J, Eng J, Engelhardt B, Erwin G, Esplin E, Esserman L, Felmeister A, Feiler H, Fields R, Fisher S, Flaherty K, Flournoy J, Ford J, Fortunato A, Frangieh A, Frye J, Fulton R, Galipeau D, Gan S, Gao J, Gao L, Gao P, Gao V, Geiger T, George A, Getz G, Ghosh S, Giannakis M, Gibbs D, Gillanders W, Goecks J, Goedegebuure S, Gould A, Gowers K, Gray J, Greenleaf W, Gresham J, Guerriero J, Guha T, Guimaraes A, Guinney J, Gutman D, Hacohen N, Hanlon S, Hansen C, Harismendy O, Harris K, Hata A, Hayashi A, Heiser C, Helvie K, Herndon J, Hirst G, Hodi F, Hollmann T, Horning A, Hsieh J, Hughes S, Huh W, Hunger S, Hwang S, Iacobuzio-Donahue C, Ijaz H, Izar B, Jacobson C, Janes S, Jané-Valbuena J, Jayasinghe R, Jiang L, Johnson B, Johnson B, Ju T, Kadara H, Kaestner K, Kagan J, Kalinke L, Keith R, Khan A, Kibbe W, Kim A, Kim E, Kim J, Kolodzie A, Kopytra M, Kotler E, Krueger R, Krysan K, Kundaje A, Ladabaum U, Lake B, Lam H, Laquindanum R, Lau K, Laughney A, Lee H, Lenburg M, Leonard C, Leshchiner I, Levy R, Li J, Lian C, Lim K, Lin J, Lin Y, Liu Q, Liu R, Lively T, Longabaugh W, Longacre T, X. C, Macedonia M, Madison T, Maher C, Maitra A, Makinen N, Makowski D, Maley C, Maliga Z, Mallo D, Maris J, Markham N, Marks J, Martinez D, Mashl R, Masilionais I, Mason J, Massagué J, Massion P, Mattar M, Mazurchuk R, Mazutis L, Mazzilli S, McKinley E, McMichael J, Merrick D, Meyerson M, Miessner J, Mills G, Mills M, Mondal S, Mori M, Mori Y, Moses E, Mosse Y, Muhlich J, Murphy G, Navin N, Nawy T, Nederlof M, Ness R, Nevins S, Nikolov M, Nirmal A, Nolan G, Novikov E, Oberdoerffer P, O’Connell B, Offin M, Oh S, Olson A, Ooms A, Ossandon M, Owzar K, Parmar S, Patel T, Patti G, Pe’er D, Pe'er I, Peng T, Persson D, Petty M, Pfister H, Polyak K, Pourfarhangi K, Puram S, Qiu Q, Quintanal-Villalonga Á, Raj A, Ramirez-Solano M, Rashid R, Reeb A, Regev A, Reid M, Resnick A, Reynolds S, Riesterer J, Rodig S, Roland J, Rosenfield S, Rotem A, Roy S, Rozenblatt-Rosen O, Rudin C, Ryser M, Santagata S, Santi-Vicini M, Sato K, Schapiro D, Schrag D, Schultz N, Sears C, Sears R, Sen S, Sen T, Shalek A, Sheng J, Sheng Q, Shoghi K, Shrubsole M, Shyr Y, Sibley A, Siex K, Simmons A, Singer D, Sivagnanam S, Slyper M, Snyder M, Sokolov A, Song S, Sorger P, Southard-Smith A, Spira A, Srivastava S, Stein J, Storm P, Stover E, Strand S, Su T, Sudar D, Sullivan R, Surrey L, Suvà M, Tan K, Terekhanova N, Ternes L, Thammavong L, Thibault G, Thomas G, Thorsson V, Todres E, Tran L, Tyler M, Uzun Y, Vachani A, Van Allen E, Vandekar S, Veis D, Vigneau S, Vossough A, Waanders A, Wagle N, Wang L, Wendl M, West R, Williams E, Wu C, Wu H, Wu H, Wyczalkowski M, Xie Y, Yang X, Yapp C, Yu W, Yuan Y, Zhang D, Zhang K, Zhang M, Zhang N, Zhang Y, Zhao Y, Zhou D, Zhou Z, Zhu H, Zhu Q, Zhu X, Zhu Y, Zhuang X. The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution. Cell 2020, 181: 236-249. PMID: 32302568, PMCID: PMC7376497, DOI: 10.1016/j.cell.2020.03.053.
- Jae Huh W, Niitsu H, Carney B, McKinley ET, Houghton JL, Coffey RJ. Identification and Characterization of Unique Neutralizing Antibodies to Mouse EGF Receptor. Gastroenterology 2020, 158: 1500-1502. PMID: 31866246, PMCID: PMC7103561, DOI: 10.1053/j.gastro.2019.12.017.
- Huh WJ, Roland JT, Asai M, Kaji I. Distribution of duodenal tuft cells is altered in pediatric patients with acute and chronic enteropathy. Biomedical Research 2020, 41: 113-118. PMID: 32307399, PMCID: PMC10037909, DOI: 10.2220/biomedres.41.113.
- Byrd KM, Piehl NC, Patel JH, Huh WJ, Sequeira I, Lough KJ, Wagner BL, Marangoni P, Watt FM, Klein OD, Coffey RJ, Williams SE. Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress. Cell Stem Cell 2019, 25: 814-829.e6. PMID: 31809739, PMCID: PMC6925542, DOI: 10.1016/j.stem.2019.11.005.
- Ajayi T, Dawodu E, Huh W, Scanga A, Izzy M. 2357 Drug-Induced Liver Injury (DILI) Does Not Always Follow the Textbook. The American Journal Of Gastroenterology 2019, 114: s1312-s1313. DOI: 10.14309/01.ajg.0000598960.07963.76.
- Markham N, Cao Z, Kasturi S, Fry W, Huh W, Coffey R. Sa1117 – Tnks2 Promotes Wnt/Β-Catenin Signaling Through Degredation of Nkd2 in Colon Cancer Cells. Gastroenterology 2019, 156: s-275. DOI: 10.1016/s0016-5085(19)37500-6.
- Huh W, Niitsu H, McKinley E, Carney B, Houghton J, Coffey R. Sa1741 – Identification and Characterization of the First Neutralizing Antibody to Mouse Egfr. Gastroenterology 2019, 156: s-383. DOI: 10.1016/s0016-5085(19)37808-4.
- Markham NO, Huh WJ, Coffey RJ. Linking ALDH1 and retinoic acid signaling. Oncotarget 2019, 10: 1226-1227. PMID: 30815222, PMCID: PMC6383818, DOI: 10.18632/oncotarget.26661.
- Huh W, Coffey R. Abstract A34: EGF receptor-activated Notch signaling contributes to pathogenesis of premalignant gastric lesions. Cancer Research 2018, 78: a34-a34. DOI: 10.1158/1538-7445.mousemodels17-a34.
- Huh W, Rhoades K, Coffey R. Sa1629 - Testosterone-Dependent Differential Expression of Egfr in Male and Female Mice and Its Implications for Carcinogenesis and Treatment Response. Gastroenterology 2018, 154: s-333-s-334. DOI: 10.1016/s0016-5085(18)31453-7.
- Markham N, Fry W, Cao Z, Huh W, Coffey R. Su2036 - TNKS2 Promotes WNT/β-Catenin Signaling through Parylation of NKD2 in Colon Cancer Cells. Gastroenterology 2018, 154: s-1365. DOI: 10.1016/s0016-5085(18)34460-3.
- Yang YP, Ma H, Starchenko A, Huh WJ, Li W, Hickman FE, Zhang Q, Franklin JL, Mortlock DP, Fuhrmann S, Carter BD, Ihrie RA, Coffey RJ. A Chimeric Egfr Protein Reporter Mouse Reveals Egfr Localization and Trafficking In Vivo. Cell Reports 2017, 19: 1257-1267. PMID: 28494873, PMCID: PMC5517093, DOI: 10.1016/j.celrep.2017.04.048.
- Huh W, Coffey R. 987 EGFR-Activated Notch Signaling Contributes to Pathogenesis of Ménétrier's Disease. Gastroenterology 2017, 152: s187. DOI: 10.1016/s0016-5085(17)30936-8.
- Charoenpitakchai M, Liu E, Zhao Z, Koyama T, Huh WJ, Berlin J, Hande K, Walker R, Shi C. In liver metastases from small intestinal neuroendocrine tumors, SSTR2A expression is heterogeneous. Virchows Archiv 2017, 470: 545-552. PMID: 28213807, PMCID: PMC5623953, DOI: 10.1007/s00428-017-2093-3.
- Gonzalez RS, Huh WJ, Cates JM, Washington K, Beauchamp RD, Coffey RJ, Shi C. Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial–mesenchymal transition. Histopathology 2016, 70: 223-231. PMID: 27560620, PMCID: PMC5921077, DOI: 10.1111/his.13068.
- Gonzalez RS, Gilger MA, Huh WJ, Washington MK. The Spectrum of Histologic Findings in Hepatic Outflow Obstruction. Archives Of Pathology & Laboratory Medicine 2016, 141: 98-103. PMID: 27681331, PMCID: PMC6420777, DOI: 10.5858/arpa.2015-0388-oa.
- Moore BD, Khurana SS, Huh WJ, Mills JC. Hepatocyte nuclear factor 4α is required for cell differentiation and homeostasis in the adult mouse gastric epithelium. AJP Gastrointestinal And Liver Physiology 2016, 311: g267-g275. PMID: 27340127, PMCID: PMC5007292, DOI: 10.1152/ajpgi.00195.2016.
- Huh WJ, Coffey RJ, Washington MK. Ménétrier’s Disease: Its Mimickers and Pathogenesis. Journal Of Pathology And Translational Medicine 2015, 50: 10-16. PMID: 26689786, PMCID: PMC4734964, DOI: 10.4132/jptm.2015.09.15.
- Moon CM, Kim SH, Lee SK, Hyeon J, Koo JS, Lee S, Wang JS, Huh WJ, Khurana SS, Mills JC. Chronic Tamoxifen Use Is Associated with a Decreased Risk of Intestinal Metaplasia in Human Gastric Epithelium. Digestive Diseases And Sciences 2013, 59: 1244-1254. PMID: 24368421, PMCID: PMC4035390, DOI: 10.1007/s10620-013-2994-1.
- Evolution of the human gastrokine locus and confounding factors regarding the pseudogenicity of GKN3Geahlen JH, Lapid C, Thorell K, Nikolskiy I, Huh WJ, Oates EL, Lennerz JK, Tian X, Weis VG, Khurana SS, Lundin SB, Templeton AR, Mills JC. Evolution of the human gastrokine locus and confounding factors regarding the pseudogenicity of GKN3. Physiological Genomics 2013, 45: 667-683. PMID: 23715263, PMCID: PMC3742967, DOI: 10.1152/physiolgenomics.00169.2012.
- Huh W, Albanese J, Salavaggione L, Liu Q, Neuschwander-Tetri B, Brunt E. 804 Hepatic Zonation in a Nonalcoholic Steatohepatitis Mouse Model. Gastroenterology 2013, 144: s-963. DOI: 10.1016/s0016-5085(13)63578-7.
- Khurana S, Huh W, Moore B, Riehl T, Stenson W, Mills J. The presumptive gastric corpus stem cell population is CD44‐positive and expands during metaplasia via increased ERK‐MAPK signaling. The FASEB Journal 2012, 26: 1160.3-1160.3. DOI: 10.1096/fasebj.26.1_supplement.1160.3.
- Huh WJ, Khurana SS, Geahlen JH, Kohli K, Waller RA, Mills JC. Tamoxifen Induces Rapid, Reversible Atrophy, and Metaplasia in Mouse Stomach. Gastroenterology 2011, 142: 21-24.e7. PMID: 22001866, PMCID: PMC3708546, DOI: 10.1053/j.gastro.2011.09.050.
- Huh WJ, Esen E, Geahlen JH, Bredemeyer AJ, Lee A, Shi G, Konieczny SF, Glimcher LH, Mills JC. XBP1 Controls Maturation of Gastric Zymogenic Cells by Induction of MIST1 and Expansion of the Rough Endoplasmic Reticulum. Gastroenterology 2010, 139: 2038-2049. PMID: 20816838, PMCID: PMC2997137, DOI: 10.1053/j.gastro.2010.08.050.
- Lennerz JK, Kim SH, Oates EL, Huh WJ, Doherty JM, Tian X, Bredemeyer AJ, Goldenring JR, Lauwers GY, Shin YK, Mills JC. The Transcription Factor MIST1 Is a Novel Human Gastric Chief Cell Marker Whose Expression Is Lost in Metaplasia, Dysplasia, and Carcinoma. American Journal Of Pathology 2010, 177: 1514-1533. PMID: 20709804, PMCID: PMC2928982, DOI: 10.2353/ajpath.2010.100328.
- Huh WJ, Mysorekar IU, Mills JC. Inducible activation of Cre recombinase in adult mice causes gastric epithelial atrophy, metaplasia, and regenerative changes in the absence of “floxed” alleles. AJP Gastrointestinal And Liver Physiology 2010, 299: g368-g380. PMID: 20413717, PMCID: PMC3774481, DOI: 10.1152/ajpgi.00021.2010.
- Huh W, Esen E, Bredemeyer A, Shi G, Lee A, Konieczny S, Glimcher L, Mills J. 863 XBP1 Is Required for the Maturation and the Maintenance of Digestive-Enzyme Secreting Zymogenic (Chief) Cells. Gastroenterology 2009, 136: a-132. DOI: 10.1016/s0016-5085(09)60592-8.
- Capoccia BJ, Huh WJ, Mills JC. How form follows functional genomics: gene expression profiling gastric epithelial cells with a particular discourse on the parietal cell. Physiological Genomics 2009, 37: 67-78. PMID: 19208773, PMCID: PMC2685495, DOI: 10.1152/physiolgenomics.90408.2008.
- Bredemeyer AJ, Geahlen JH, Weis VG, Huh WJ, Zinselmeyer BH, Srivatsan S, Miller MJ, Shaw AS, Mills JC. The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage. Developmental Biology 2008, 325: 211-224. PMID: 19013146, PMCID: PMC2634829, DOI: 10.1016/j.ydbio.2008.10.025.
- Huh WJ, Pan XO, Mysorekar IU, Mills JC. Location, allocation, relocation: isolating adult tissue stem cells in three dimensions. Current Opinion In Biotechnology 2006, 17: 511-517. PMID: 16889955, DOI: 10.1016/j.copbio.2006.07.002.
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