Maricar Malinis, MD, FACP, FIDSA, FAST
Biography
Maricar Malinis, MD, is an infectious disease specialist who focuses on patients with end-stage organ disease before and after transplantation. She evaluates transplant candidates and educates them about preventive strategies to reduce the risk of infections after transplant. She tells new patients: “I am here to listen, help, and guide you to make the best possible decision that is compatible with your goals of care and quality of life.”
An associate professor of medicine (infectious diseases) with a secondary appointment in surgery (transplant) at Yale School of Medicine, Dr. Malinis is also a researcher focusing on clinical outcomes of special transplant populations, including older adults and people living with HIV. Also, she treats complicated infections in immunocompromised hosts, including solid organ and stem cell transplant recipients.
Dr. Malinis is most excited about her involvement in a clinical trial study of organ transplantation in which both donors and recipients have HIV. In collaboration with Johns Hopkins University and the New England Organ Bank, she assisted with the donation process for the first HIV to HIV-positive liver and kidney transplants. “This study can potentially expand the donor pool and decrease waitlist times for HIV-positive candidates,” she says.
Titles
- Associate Professor of Medicine
- Medical Director, Transplant and Oncology Infectious Diseases, Section of Infectious Diseases
Education & Training
- Clinical Research FellowYale School of Medicine (2012)
- Clinical Transplant ID FellowCleveland Clinic Foundation (2011)
- Infectious Diseases FellowUniversity of Louisville (2007)
- Infectious Diseases FellowHarlem Hospital affiliated with Columbia University of Physicians and Surgeons (2006)
- Geriatric Medicine FellowUniversity of Michigan (2005)
- ResidencySeton Hall University School of Graduate Medical Education (2004)
- MDUniversity of Philippines, College of Medicine (2000)
- BSUniversity of the Philippines-Diliman, Chemistry (1995)
Languages Spoken
- English
- Filipino
Additional Information
- Fellow: American Society of Transplantation (2018)
- Fellow: Infectious Diseases Society of America (2017)
- Honorable Mention, Team Award: National Compassionate Caregiver of the Year Award (2017)
- Fellow: American College of Physicians (2014)
- Infectious Diseases Society of America (2020 - Present): Vice Chair, Digital Strategy Advisory Group
- American Society of Transplantation (2020 - Present): Member-at-Large, Infectious Diseases Community of Practice Executive Committee
- Transplant Infectious Diseases of the Transplantation Society (2019 - Present): Council Member
- Infectious Diseases Society of America (2019 - Present): Member, Digital Strategy Advisory Group
- Infectious Diseases Society of America (2018 - 2019): Peer Reviewer, IDSA Leadership Institute Selection Task Force
- American Society of Transplantation (2018 - Present): Lead, Older Patient Interest Group of the AST Infectious Diseases Community of Practice
- Infectious Diseases Society of America (2017 - Present): Member, Clinical Affairs Committee
- United Network for Organ Sharing (2017 - 2020): Member at Large, Ad Hoc Donor Transmission Advisory Committee
- American Society of Transplantation (2011 - Present): Member, AST Infectious Diseases Community of Practice
- Malinis MF, Mawhorter SD, Jain A, Shrestha NK, Avery RK, van Duin D. Staphylococcus aureus bacteremia in solid organ transplant recipients: evidence for improved survival when compared with nontransplant patients. Transplantation 2012, 93:1045-50.
- Malinis MF, Chen S, Allore HG, Quagliarello VJ. Outcomes among older adult liver transplantation recipients in the model of end stage liver disease (MELD) era. Annals Of Transplantation 2014, 19:478-87.
- Bernardo RM, Gurung A, Jain D, Malinis MF. Therapeutic Challenges of Hepatic Mucormycosis in Hematologic Malignancy: A Case Report and Review of the Literature. The American Journal Of Case Reports 2016, 17:484-9.
- Baghban A, Azar MM, Bernardo RM, Malinis M. Disseminated Mycobacterium tuberculosis following renal transplant with alemtuzumab induction. BMJ Case Reports 2016, 2016.
- Azar MM, Assi R, Patel N, Malinis MF. Fungal Mycotic Aneurysm of the Internal Carotid Artery Associated with Sphenoid Sinusitis in an Immunocompromised Patient: A Case Report and Review of the Literature. Mycopathologia 2016, 181:425-33.
- Azar MM, Malinis MF. Disseminated Histoplasmosis with Skin Lesions and Osteomyelitis in a Patient from the Philippines. The American Journal Of Tropical Medicine And Hygiene 2016, 95:70-4.
- Helou E, Grant M, Landry M, Wu X, Morrow JS, Malinis MF. Fatal case of cutaneous-sparing orolaryngeal zoster in a renal transplant recipient. Transplant Infectious Disease : An Official Journal Of The Transplantation Society 2017, 19.
- Azar MM, Malinis MF, Moss J, Formica RN, Villanueva MS. Integrase strand transferase inhibitors: the preferred antiretroviral regimen in HIV-positive renal transplantation. International Journal Of STD & AIDS 2017, 28:447-458.
- Azar MM, Assi R, Valika AK, Banach DB, Hall IE, Landry ML, Malinis MF. Graft loss among renal-transplant recipients with early reduction of immunosuppression for BK viremia. World Journal Of Transplantation 2017, 7:269-275.
- Ogbuagu O, Hao R, Virata M, Villanueva MS, Malinis M. Efficacy of an 8-week course of sofosbuvir and ledipasvir for the treatment of HCV infection in selected HIV-infected patients. F1000Research 2017, 6:620.
- Azar MM, Zhang X, Assi R, Hage C, Wheat LJ, Malinis MF. Clinical and epidemiological characterization of histoplasmosis cases in a nonendemic area, Connecticut, United States. Medical Mycology 2018, 56:896-899.
- Fu W, Merola J, Malinis M, Lacy J, Barbieri A, Liapakis AH, Mulligan DC, Yoo PS. Successful treatment of primary donor-derived human herpesvirus-8 infection and hepatic Kaposi Sarcoma in an adult liver transplant recipient. Transplant Infectious Disease : An Official Journal Of The Transplantation Society 2018, 20:e12966.
- Baghban A, Malinis M. Ganciclovir and foscarnet dual-therapy for cytomegalovirus encephalitis: A case report and review of the literature. Journal Of The Neurological Sciences 2018, 388:28-36.
- Malinis MF. Management of Mycobacterium Other than Tuberculosis in Solid Organ Transplantation. Infectious Disease Clinics Of North America 2018, 32:719-732.
- Perreault S, McManus D, Bar N, Foss F, Gowda L, Isufi I, Seropian S, Malinis M, Topal JE. The impact of a multimodal approach to vancomycin discontinuation in hematopoietic stem cell transplant recipients (HSCT) with febrile neutropenia (FN). Transplant Infectious Disease : An Official Journal Of The Transplantation Society 2019, 21:e13059.
- Shallis RM, Gleeson S, Azar M, Malinis M, Xu ML, Seropian SE, Gowda L, Zeidan AM. Allogeneic stem cell transplantation and combination antiretroviral therapy: cautions, complications, and considerations. Leukemia & Lymphoma 2019, 60:2584-2587.
- Malinis M, Boucher HW. Screening of donor and candidate prior to solid organ transplantation-Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clinical Transplantation 2019, 33:e13548.
- Sherbuk JE, McManus D, Topal JE, Malinis M. Improved mortality in Staphylococcus aureus bacteremia with the involvement of antimicrobial stewardship team and infectious disease consultation. Infection Control And Hospital Epidemiology 2019, 40:932-935.
- Schaenman J, Goldwater D, Malinis M. An interdisciplinary approach to the older transplant patient: strategies for improving clinical outcomes. Current Opinion In Organ Transplantation 2019, 24:504-510.
- Koval CE, Farr M, Krisl J, Haidar G, R Pereira M, Shrestha N, Malinis MF, Mueller NJ, M Hannan M, Grossi P, Huprikar S. Heart or lung transplant outcomes in HIV-infected recipients. The Journal Of Heart And Lung Transplantation : The Official Publication Of The International Society For Heart Transplantation 2019, 38:1296-1305.
- Durand CM, Werbel W, Doby B, Brown D, Desai NM, Malinis M, Price J, Chin-Hong P, Mehta S, Friedman-Moraco R, Turgeon NA, Gilbert A, Morris MI, Stosor V, Elias N, Aslam S, Santos CAQ, Hand JM, Husson J, Pruett TL, Agarwal A, Adebiyi O, Pereira M, Small CB, Apewokin S, Heun Lee D, Haidar G, Blumberg E, Mehta SA, Huprikar S, Florman SS, Redd AD, Tobian AAR, Segev DL. Clarifying the HOPE Act landscape: The challenge of donors with false-positive HIV results. American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons 2020, 20:617-619.
- Azar MM, Slotkin R, Abi-Raad R, Liu Y, Grant MH, Malinis MF. Gomori Methenamine Silver Stain on Bronchoalveolar Lavage Fluid Is Poorly Sensitive for Diagnosis of Pneumocystis jiroveci Pneumonia in HIV-Negative Immunocompromised Patients and May Lead to Missed or Delayed Diagnoses. Archives Of Pathology & Laboratory Medicine 2020.
- Azar MM, Gaston DC, Kotton CN, Malinis MF. Emerging Microbiology Diagnostics for Transplant Infections: On the Cusp of a Paradigm Shift. Transplantation 2020, 104:1358-1384.
- Nussbaum EZ, Azar MM, Cohen E, McManus D, Topal JE, Malinis M. Orally Administered Human Immunoglobulin Therapy for Norovirus Enteritis in Solid Organ Transplant Recipients: A Case Series at a Single Academic Transplant Center. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 2020, 71:e206-e209.
- Koff A, Malinis M, Delgado S, Grant M, Ahmad T. Under Our Very Eyes. The New England Journal Of Medicine 2020, 382:952-957.
- Sarwar S, Koff A, Malinis M, Azar MM. Daptomycin perioperative prophylaxis for the prevention of vancomycin-resistant Enterococcus infection in colonized liver transplant recipients. Transplant Infectious Disease : An Official Journal Of The Transplantation Society 2020, 22:e13280.
- Seaman SM, Van Pilsum Rasmussen SE, Nguyen AQ, Halpern SE, You S, Waldram MM, Anjum SK, Bowring MG, Muzaale AD, Ostrander DB, Brown D, Massie AB, Tobian AAR, Henderson ML, Fletcher FE, Smith B, Chao A, Gorupati N, Prakash K, Aslam S, Lee DH, Kirchner V, Pruett TL, Haidar G, Hughes K, Malinis M, Trinh S, Segev DL, Sugarman J, Durand CM. Brief Report: Willingness to Accept HIV-Infected and Increased Infectious Risk Donor Organs Among Transplant Candidates Living With HIV. Journal Of Acquired Immune Deficiency Syndromes (1999) 2020, 85:88-92.
- Koff A, Malinis M. Chest Pain and a Cavitary Lung Mass in a Woman With Diabetes. JAMA 2020, 323:2421-2422.
- Davis MW, McManus D, Koff A, Jaszczur GR, Malinis M, Dela Cruz C, Britto CJ, Price C, Azmy V, Kaman K, Gaston D, Early K, DeWitt M, Song JS, Ortiz C, Juthani-Mehta M, Topal JE. Repurposing antimicrobial stewardship tools in the electronic medical record for the management of COVID-19 patients. Infection Control And Hospital Epidemiology 2020, 41:1335-1337.
- Price CC, Altice FL, Shyr Y, Koff A, Pischel L, Goshua G, Azar MM, Mcmanus D, Chen SC, Gleeson SE, Britto CJ, Azmy V, Kaman K, Gaston DC, Davis M, Burrello T, Harris Z, Villanueva MS, Aoun-Barakat L, Kang I, Seropian S, Chupp G, Bucala R, Kaminski N, Lee AI, LoRusso PM, Topal JE, Dela Cruz C, Malinis M. Tocilizumab Treatment for Cytokine Release Syndrome in Hospitalized Patients With Coronavirus Disease 2019: Survival and Clinical Outcomes. Chest 2020, 158:1397-1408.
- Kates OS, Haydel BM, Florman SS, Rana MM, Chaudhry ZS, Ramesh MS, Safa K, Kotton CN, Blumberg EA, Besharatian BD, Tanna SD, Ison MG, Malinis M, Azar MM, Rakita RM, Morillas JA, Majeed A, Sait AS, Spaggiari M, Hemmige V, Mehta SA, Neumann H, Badami A, Goldman JD, Lala A, Hemmersbach-Miller M, McCort ME, Bajrovic V, Ortiz-Bautista C, Friedman-Moraco R, Sehgal S, Lease ED, Fisher CE, Limaye AP. COVID-19 in solid organ transplant: A multi-center cohort study. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 2020.
- Theodoropoulos NM, La Hoz RM, Wolfe C, Vece G, Bag R, Berry GJ, Bucio J, Danziger-Isakov L, Florescu DF, Goldberg D, Ho CS, Lilly K, Malinis M, Mehta AK, Nalesnik MA, Sawyer R, Strasfeld L, Wood RP, Michaels MG. Donor derived hepatitis B virus infection: Analysis of the Organ Procurement & Transplantation Network/United Network for Organ Sharing Ad Hoc Disease Transmission Advisory Committee. Transplant Infectious Disease : An Official Journal Of The Transplantation Society 2020, e13458.
- Caraballo C, McCullough M, Fuery MA, Chouairi F, Keating C, Ravindra NG, Miller PE, Malinis M, Kashyap N, Hsiao A, Wilson FP, Curtis JP, Grant M, Velazquez EJ, Desai NR, Ahmad T. COVID-19 infections and outcomes in a live registry of heart failure patients across an integrated health care system. PloS One 2020, 15:e0238829.
- Transplant Adenovirus Infection: Clinical Syndromes, Diagnosis, and ManagementEmerging Transplant Infections, Springer
- Koff A, Laurent-Rolle M, Hsu JC, Malinis M. Prolonged incubation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a patient on rituximab therapy. Infection Control And Hospital Epidemiology 2020, 1-2.
- Lier AJ, Virmani S, Ilagan-Ying Y, Leelatian N, Darbinyan A, Malinis M. Unilateral leg pain caused by cryptococcal myositis: An unusual presentation of disseminated cryptococcosis in a kidney transplant recipient. Transplant Infectious Disease : An Official Journal Of The Transplantation Society 2020, e13491.
- Gaston DC, Malinis M, Osborn R, Peaper DR, Landry M, Juthani-Mehta M, Azar MM. Clinical implications of SARS-CoV-2 cycle threshold values in solid organ transplant recipients. American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons 2020.
- Zimmerman A, Rogers R, Tan CS, Pavlakis M, Bodziak K, Cardarelli F, Francis J, Gabardi S, Germain M, Ghai S, Gilligan H, Goyal N, Malinis M, Patel H, Rodig N, Theodoropoulos NM, Walshe E, Wood E, Chobanian M. Expecting the unexpected: COVID-19 in Kidney Transplant Recipients within United Network for Organ Sharing Region 1. Transplant International : Official Journal Of The European Society For Organ Transplantation 2020, 33:1843-1844.
- Brzozowski K, Datta R, Canterino J, Malinis M, Juthani-Mehta M. Adverse Events and Healthcare Utilization Associated With Outpatient Parenteral Antimicrobial Therapy Among Older Versus Younger Adults. Open Forum Infectious Diseases 2020, 7:ofaa358.
- Trubin PA, Azar MM, Malinis M. Diagnostic Testing of COVID-19 in Solid Organ Transplantation: Current Clinical Application and Future Strategies. Current Transplantation Reports 2020, 1-9.
- Malinis M, McManus D, Davis M, Topal J. An overview on the use of antivirals for the treatment of patients with COVID19 disease. Expert Opinion On Investigational Drugs 2021, 30:45-59.
- Azar MM, Schlaberg R, Malinis MF, Bermejo S, Schwarz T, Xie H, Dela Cruz CS. Added Diagnostic Utility Of Clinical Metagenomics For The Diagnosis Of Pneumonia In Immunocompromised Adults. Chest 2020.
- Nussbaum EZ, Patel KK, Assi R, Raad RA, Malinis M, Azar MM. Clinicopathologic Features of Tissue Granulomas in Transplant Recipients: A Single Center Study in a Nontuberculosis Endemic Region. Archives Of Pathology & Laboratory Medicine 2020.
- Penumarthi LR, La Hoz RM, Wolfe CR, Jackson BR, Mehta AK, Malinis M, Danziger-Isakov L, Strasfeld L, Florescu DF, Vece G, Basavaraju SV, Michaels MG. Cryptococcus transmission through solid organ transplantation in the United States: A Report from the Ad Hoc Disease Transmission Advisory Committee. American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons 2020.
- Heldman MR, Kates OS, Haydel BM, Florman SS, Rana MM, Chaudhry ZS, Ramesh MS, Safa K, Kotton CN, Blumberg EA, Besharatian BD, Tanna SD, Ison MG, Malinis M, Azar MM, Rakita RM, Morillas JA, Majeed A, Sait AS, Spaggiari M, Hemmige V, Mehta SA, Neumann H, Badami A, Jeng A, Goldman JD, Lala A, Hemmersbach-Miller M, McCort ME, Bajrovic V, Ortiz-Bautista C, Friedman-Moraco R, Sehgal S, Lease ED, Limaye AP, Fisher CE. Healthcare resource use among solid organ transplant recipients hospitalized with COVID-19. Clinical Transplantation 2020, e14174.
- Ringer M, Azmy V, Kaman K, Tang D, Cheung H, Azar MM, Price C, Malinis M. A retrospective matched cohort single-center study evaluating outcomes of COVID-19 and the impact of immunomodulation on COVID-19-related cytokine release syndrome in solid organ transplant recipients. Transplant Infectious Disease : An Official Journal Of The Transplantation Society 2020, e13556.
- Azmy V, Kaman K, Tang D, Zhao H, Dela Cruz C, Topal JE, Malinis M, Price CC. Cytokine Profiles Before and After Immune Modulation in Hospitalized Patients with COVID-19. Journal Of Clinical Immunology 2021.
- Yale Infectious DiseasesYale Physicians Building800 Howard AvenueNew Haven, CT, 06519
- Yale AIDS Care ProgramLaboratory for Medicine and Pediatrics (LMP)15 York Street, Ste Nathan Smith ClinicNew Haven, CT, 06510