Joseph Brennan, MD, BS
Joseph Brennan, MD, has been providing cardiac care to Yale Medicine patients for more than 25 years. He specializes in coronary artery disease, hyperlipidemia and cardiac valvular abnormalities, among other problems.
In addition to his clinical practice, Dr. Brennan is medical director for the Coronary Intensive Care Unit and director of inpatient cardiology services at Yale New Haven Hospital. His clinical research interests include developing newer coronary devices and “working on minimally invasive techniques to treat issues that previously would have required surgery,” he says. Dr. Brennan is an associate professor of medicine (cardiology) at Yale School of Medicine.
- Professor of Clinical Medicine (Cardiovascular Medicine)
- Firm Chief- Coronary Intensive Care Unit (CICU), Internal Medicine
- Director, Interventional Cardiology Fellowship Program, Internal Medicine
- Medical Director, Coronary Intensive Care Unit, Yale-New Haven Hospital, Yale Medicine
- Director, Inpatient Cardiology Services, Yale Medicine
Education & Training
- FellowYale New Haven Hospital (1990)
- Chief ResidentYale New Haven Hospital (1987)
- ResidentYale New Haven Hospital (1986)
- MDMedical College of Virginia, Richmond, Virginia (1983)
- BSCollege of William and Mary, Biology (1978)
- Fred Kantor Internal Medicine Residency Teaching Award: Yale University (2020)
- Leonard Tow Humanism in Medicine Award: (2017)
- Teacher of the Year Yale Primary Care Residency: (2015)
- Master Clinician Yale Primary Care Residency: (2015)
- Consultant of the Year Given by ED Residents: (2013)
- Teacher of the Year Cardiology Section: (2012)
- Nurses Choice Award: (2012)
- Teacher of the Year Yale Traditional Internal Medicine Residency: (2011)
- "Top Docs": Connecticut Magazine (2010), (2011), (2012), (2013), (2014), (2015), (2016), (2017), (2018), (2019)
- Fellow, Society of Coronary Angiography and Interventions (SCAI): (2005)
- Department of Internal Medicine (2019 - Present): Facilitator/participant in Department of Internal Medicine's Medical Error Disclosure and Critical Conversations Panel.
- Department of Internal Medicine-Section of Cardiovascular Disease (2018 - 2019): Served as member of a clinical redesign committee within the Section of Cardiovascular Disease which had been tasked to redesign the large inpatient cardiac service.
- Department of Internal Medicine-RISE (Resilience,Innovation and Sustainable Excellence) Faculty (2018 - Present): Discussant/Presenter/Facilitator at Workshops for new "hires" in Department of Internal Medicine at New Faculty Orientation.
- Clinical Events Committee- LAAO Registry. ClinicalTrials.gov Identifier: NCT02699957 (2018 - Present): Chair of committee to adjudicate events The Left Atrial Appendage Occlusion Registry (LAAO Registry™) is designed to assess the prevalence, demographics, management, and outcomes of patients undergoing percutaneous and epicardial based left atrial appendage occlusion procedures to reduce the risk of stroke. Patient-level data will be submitted by participating hospitals on a quarterly basis to the American College of Cardiology Foundation's National Cardiovascular Data Registry (NCDR). The primary aims of the LAAO Registry are to optimize the outcomes and management of patients through the implementation of evidence-based guideline recommendations in clinical practice, facilitate efforts to improve the quality and safety for patients undergoing percutaneous and epicardial based left atrial appendage procedures, investigate novel quality improvement methods and provide risk-adjusted assessment of patients for comparison with nationwide NCDR data.
- Clinical Event Committee-REFLECT Trial. ClinicalTrials.gov Identifier: NCT02536196 (2018 - 2019): Serving as member of Clinical Event Committee (CEC) for REFLECT Trial, adjudicating all outcome events for this large trial.The Keystone Heart TriGuard™ HDH is an aortic embolism deflection device intended to reduce the amount of embolic material that may enter the carotid, subclavian, and vertebral arteries during transcatheter heart valve implantation. The objective of the study is to assess the safety and efficacy of the TriGuard™ HDH embolic deflection device in patients undergoing transcatheter aortic valve implantation (TAVI), in comparison with an active control group of patients undergoing unprotected TAVI.
- Clinical Events Committee-YALE NeuroTAVR - Neurological Complications of Contemporary Unprotected TAVR (Yale Neuro TAVR). Sponsor: Keystone Heart. ClinicalTrials.gov Identifier: NCT02073864. A prospective, multi-center study enrolling a minimum of 20 up to a maximum of 80 patients at up to six (6) investigational sites in the United States and European Union. (2017 - Present): Member, Clinical Events Committee to adjudicate neurologic and other clinical events associated with TAVR.
- Clinical Events Committee-BIOHELIX I. Bare Metal Stent Study. Sponsor: Biotronik. ClinicalTrials.gov Identifier: NCT01612767 (2017 - 2018): Adjudicated end point and clinical events for the investigational BIOTRONIK PRO-Kinetic Energy stent in subjects with atherosclerotic disease of native coronary arteries
- Clinical Events Committee-Disrupt CAD I - Prospective Multi-Center, Single Arm Study of the Shockwave Coronary Rx Lithoplasty® System in Coronary Arteries Lithoplasty Study. Sponsor: Shockwave Medical Inc, ClinicalTrials.gov Identifier: NCT02650128. (2017 - 2018): Member, Clinical Events Committee to adjudicate events related to Lithoplasty device in coronary arteries.
- Hearts Around the World (2016): Served as physician liaison in Havana, Cuba
- Clinical Events Committee-RESTORE II Trial-ReZolve2™ Sirolimus-Eluting Bioresorbable Coronary Scaffold. Sponsor: REVA Medical. Clinical Trials.gov Identifier: NCT01845311. A prospective, multi-center, safety and performance study with a study population consisting of patients with clinical evidence of myocardial ischemia or a positive functional study. A maximum of 125 patients were to be enrolled into the study (2016 - Present): Member, Clinical Events Committee to adjudicate clinical events in study invoving a bioabsorbable coronary scaffold.
- Brennan JJ, Cabin HS. The role of anticoagulation in acute myocardial infarction. Cardiology Clinics 1988, 6:111-8.
- Characteristics of cigarette smokers versus nonsmokers in patients referred for coronary angioplastyIlia R, Brennan JJ, Cabin HS, Cleman M, Remetz M. Current Science - Coronary Artery Disease 1992, 3:859-862
- Acute closure during PTCA: Management strategies.Kolansky D, Brennan JJ, Cleman MW. The Journal of News and Reviews in Invasive Cardiology, 2:8-11, 1992
- Percutaneous transluminal coronary angioplasty in unstable and stable angina pectoris: a comparison of immediate success and complications.Ilia R, Kolansky D, Setaro J, Brennan J, Cabin H, Cleman M, Remetz M. Percutaneous transluminal coronary angioplasty in unstable and stable angina pectoris: a comparison of immediate success and complications. Cardiology 1992, 81:245-50.
- Percutaneous transluminal coronary angioplasty in the elderly: Initial results and complications.Ilia R, Kolansky D, Setaro J, Brennan JJ, Cabin H, Cleman M, Remetz M. Cardiology in the Elderly 1993; l:29-32
- Clinical and angiographic determinants of initial percutaneous transluminal coronary angioplasty success.Ilia R, Kolanski D, Setaro J, Brennan J, Cabin H, Cleman M, Remetz M. Clinical and angiographic determinants of initial percutaneous transluminal coronary angioplasty success. Angiology 1993, 44:677-82.
- Ilia R, Bigham H, Brennan J, Cabin H, Cleman M, Remetz M. Predictors of coronary dissection following percutaneous transluminal coronary balloon angioplasty. Cardiology 1994, 85:229-34.
- Physiologic assessment of ostial left circumflex coronary artery disease using a Doppler guidewire before and after rotational atherectomy facilitated angioplasty.Ling FS, Brennan JJ, Cleman MW, Cabin HS. Physiologic assessment of ostial left circumflex coronary artery disease using a Doppler guidewire before and after rotational atherectomy facilitated angioplasty. Catheterization And Cardiovascular Diagnosis 1994, 32:53-7.
- Effects of altered left ventricular geometry on quantitative technetium 99m sestamibi defect size in humans: perfusion imaging during coronary angioplasty.Haronian HL, Sinusas AJ, Remetz MS, Brennan JJ, Cabin HS, Zaret BL, Wackers FJ. Effects of altered left ventricular geometry on quantitative technetium 99m sestamibi defect size in humans: perfusion imaging during coronary angioplasty. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 1994, 1:150-8.
- Greenberg YJ, Brennan JJ, Rosenfeld LE. Lyme myocarditis presenting as fascicular tachycardia with underlying complete heart block. Journal Of Cardiovascular Electrophysiology 1997, 8:323-4.
- Modulation of circulating cellular adhesion molecules in postmenopausal women with coronary artery disease.Caulin-Glaser T, Farrell WJ, Pfau SE, Zaret B, Bunger K, Setaro JF, Brennan JJ, Bender JR, Cleman MW, Cabin HS, Remetz MS. Modulation of circulating cellular adhesion molecules in postmenopausal women with coronary artery disease. Journal Of The American College Of Cardiology 1998, 31:1555-60.
- Brennan JJ, Cabin HS. Revascularization strategies in patients with diabetes: evolving concepts. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2000, 7:153-8.
- Abbott JD, Curtis JP, Murad K, Kramer HM, Remetz MS, Setaro JF, Brennan JJ. Spontaneous coronary artery dissection in a woman receiving 5-fluorouracil--a case report. Angiology 2003, 54:721-4.
- Comparison of coronary artery specific leukocyte-platelet conjugate formation in unstable versus stable angina pectoris.Patel PB, Pfau SE, Cleman MW, Brennan JJ, Howes C, Remetz M, Cabin HS, Setaro JF, Rinder HM. Comparison of coronary artery specific leukocyte-platelet conjugate formation in unstable versus stable angina pectoris. The American Journal Of Cardiology 2004, 93:410-3.
- Treatment of a left internal mammary artery to pulmonary artery fistula with polytetrafluoroethylene covered stents.Abbott JD, Brennan JJ, Remetz MS. Treatment of a left internal mammary artery to pulmonary artery fistula with polytetrafluoroethylene covered stents. Cardiovascular And Interventional Radiology 2004, 27:74-6.
- Anabolic steroids, acute myocardial infarction and polycythemia: a case report and review of the literature.Stergiopoulos K, Brennan JJ, Mathews R, Setaro JF, Kort S. Anabolic steroids, acute myocardial infarction and polycythemia: a case report and review of the literature. Vascular Health And Risk Management 2008, 4:1475-80.
- Doyle R, Perry JC, Brennan J, Fahey J. Acute myocardial infarction as the presenting symptom of systemic lupus erythematosus. Pediatric Cardiology 2009, 30:858-61.
- Cellularity and structure of fresh human coronary thrombectomy specimens; presence of cells with markers of progenitor cells.Jovin IS, Lei L, Huang Y, Hao Z, Curtis JP, Brennan JJ, Remetz MS, Setaro JF, Pfau SE, Howes CJ, Clancy JF, Cabin HS, Cleman MW, Giordano FJ. Cellularity and structure of fresh human coronary thrombectomy specimens; presence of cells with markers of progenitor cells. Journal Of Cellular And Molecular Medicine 2012, 16:3022-7.
- Penciu OM, Mojibian H, Sugeng L, Cleman M, Brennan J, DePasquale E, McKenna W, Bonde P, Jacoby D. Anomalous left coronary artery in hypertrophic cardiomyopathy. The Annals Of Thoracic Surgery 2014, 97:2190-3.
- CCU Survival Guide- A Housestaff Survival GuideEditor. Written in association with the Medical Housestaff of Yale-New Haven Hospital. Shadi Kalantarian, M.D., M.P.H.
- Association of Physician Certification in Interventional Cardiology With In-Hospital Outcomes of Percutaneous Coronary Intervention.Fiorilli PN, Minges KE, Herrin J, Messenger JC, Ting HH, Nallamothu BK, Lipner RS, Hess BJ, Holmboe ES, Brennan JJ, Curtis JP. Association of Physician Certification in Interventional Cardiology With In-Hospital Outcomes of Percutaneous Coronary Intervention. Circulation 2015, 132:1816-24.
- Nitroglycerin administration during cardiac arrest caused by coronary vasospasm secondary to misoprostol.Owusu KA, Brennan JJ, Perelman A, Meoli E, Altshuler J. Nitroglycerin administration during cardiac arrest caused by coronary vasospasm secondary to misoprostol. Journal Of Cardiology Cases 2015, 12:166-168.
- Stuck Between a Clot and a Cold Place: The Specter of Early In-Stent Thrombosis With Therapeutic Hypothermia.Vaccaro BJ, Brennan J. Stuck Between a Clot and a Cold Place: The Specter of Early In-Stent Thrombosis With Therapeutic Hypothermia. JACC. Cardiovascular Interventions 2016, 9:1812-4.
- Leder SB, Warner HL, Suiter DM, Young NO, Bhattacharya B, Siner JM, Davis KA, Maerz LL, Rosenbaum SH, Marshall PS, Pisani MA, Siegel MD, Brennan JJ, Schuster KM. Evaluation of Swallow Function Post-Extubation: Is It Necessary to Wait 24 Hours? The Annals Of Otology, Rhinology, And Laryngology 2019, 128:619-624.
- Clinical Practice Patterns in Temporary Mechanical Circulatory Support for Shock in the Critical Care Cardiology Trials Network (CCCTN) Registry.Berg DD, Barnett CF, Kenigsberg BB, Papolos A, Alviar CL, Baird-Zars VM, Barsness GW, Bohula EA, Brennan J, Burke JA, Carnicelli AP, Chaudhry SP, Cremer PC, Daniels LB, DeFilippis AP, Gerber DA, Granger CB, Hollenberg S, Horowitz JM, Gladden JD, Katz JN, Keeley EC, Keller N, Kontos MC, Lawler PR, Menon V, Metkus TS, Miller PE, Nativi-Nicolau J, Newby LK, Park JG, Phreaner N, Roswell RO, Schulman SP, Sinha SS, Snell RJ, Solomon MA, Teuteberg JJ, Tymchak W, van Diepen S, Morrow DA. Clinical Practice Patterns in Temporary Mechanical Circulatory Support for Shock in the Critical Care Cardiology Trials Network (CCCTN) Registry. Circulation. Heart Failure 2019, 12:e006635.
- Ong E, Castro-Dominguez Y, Brennan J, Oen-Hsiao J. COVID-19 complicated by ST-segment elevation myocardial infarction in a 29-year-old patient. Catheterization And Cardiovascular Interventions : Official Journal Of The Society For Cardiac Angiography & Interventions 2021, 97:267-271.
- Yale CardiologyYale New Haven Hospital20 York StreetNew Haven, CT, 06510
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- Cardiovascular Services of Greenwich, PCGreenwich Hospital55 Holly Hill Lane, Ste Suite 240Greenwich, CT, 06830
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