Heart and Vascular
Yale Physicians Building
800 Howard Avenue, Fl 2
New Haven, CT 06519
- Directions

Hyung Chun, MD, FAHA

Cardiovascular Medicine

Telehealth is available

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Patient type treated

Adult

Accepting new patients

Yes

Referral required

From patients or physicians

Insurance accepted

View Academic Profile

Click here to view more about this specialist's research and educational efforts on https://medicine.yale.edu

Click here to view more about this specialist's research and educational efforts onhttps://medicine.yale.edu

Titles

Associate Professor
Director of Translational Research, Yale Pulmonary Vascular Disease Program, Internal Medicine
Co-Director of the Vascular Research T32 Training Program, Internal Medicine
Leadership Committee, 3CPR Council

Education & Training

Visiting Scholar
University of Cambridge (2017)
Chief Fellow
Stanford University (2009)
Fellowship
Stanford University (2009)
Residency
Stanford University (2004)
MD
Johns Hopkins University School of Medicine (2002)
Cloisters Scholar
HHMI (2001)
BA
Harvard University, Biochemical Sciences (1995)

Languages Spoken

English
한국어 (Korean)

Additional Information

Professional Service

Publications

Hospitalisation among vaccine breakthrough COVID-19 infections.
Juthani PV, Gupta A, Borges KA, Price CC, Lee AI, Won CH, Chun HJ. Hospitalisation among vaccine breakthrough COVID-19 infections. The Lancet. Infectious Diseases 2021, 21: 1485-1486. PMID: 34506735, PMCID: PMC8423430, DOI: 10.1016/S1473-3099(21)00558-2.
Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study.
Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI. Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. The Lancet. Haematology 2020, 7: e575-e582. PMID: 32619411, PMCID: PMC7326446, DOI: 10.1016/S2352-3026(20)30216-7.
A neutrophil activation signature predicts critical illness and mortality in COVID-19.
Meizlish ML, Pine AB, Bishai JD, Goshua G, Nadelmann ER, Simonov M, Chang CH, Zhang H, Shallow M, Bahel P, Owusu K, Yamamoto Y, Arora T, Atri DS, Patel A, Gbyli R, Kwan J, Won CH, Dela Cruz C, Price C, Koff J, King BA, Rinder HM, Wilson FP, Hwa J, Halene S, Damsky W, van Dijk D, Lee AI, Chun HJ. A neutrophil activation signature predicts critical illness and mortality in COVID-19. Blood Advances 2021, 5: 1164-1177. PMID: 33635335, PMCID: PMC7908851, DOI: 10.1182/bloodadvances.2020003568.
Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection.
Chun HJ, Coutavas E, Pine AB, Lee AI, Yu VL, Shallow MK, Giovacchini CX, Mathews AM, Stephenson B, Que LG, Lee PJ, Kraft BD. Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection. JCI Insight 2021, 6 PMID: 34111030, PMCID: PMC8410030, DOI: 10.1172/jci.insight.148476.
Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects.
Hwangbo C, Wu J, Papangeli I, Adachi T, Sharma B, Park S, Zhao L, Ju H, Go GW, Cui G, Inayathullah M, Job JK, Rajadas J, Kwei SL, Li MO, Morrison AR, Quertermous T, Mani A, Red-Horse K, Chun HJ. Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects. Science Translational Medicine 2017, 9 PMID: 28904225, PMCID: PMC5703224, DOI: 10.1126/scitranslmed.aad4000.
MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation.
Papangeli I, Kim J, Maier I, Park S, Lee A, Kang Y, Tanaka K, Khan OF, Ju H, Kojima Y, Red-Horse K, Anderson DG, Siekmann AF, Chun HJ. MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation. Nature Communications 2016, 7: 11268. PMID: 27068353, PMCID: PMC4832062, DOI: 10.1038/ncomms11268.
Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension.
Kim J, Hwangbo C, Hu X, Kang Y, Papangeli I, Mehrotra D, Park H, Ju H, McLean DL, Comhair SA, Erzurum SC, Chun HJ. Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension. Circulation 2015, 131: 190-9. PMID: 25336633, PMCID: PMC4293354, DOI: 10.1161/CIRCULATIONAHA.114.013339.
An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension.
Kim J, Kang Y, Kojima Y, Lighthouse JK, Hu X, Aldred MA, McLean DL, Park H, Comhair SA, Greif DM, Erzurum SC, Chun HJ. An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension. Nature Medicine 2013, 19: 74-82. PMID: 23263626, PMCID: PMC3540168, DOI: 10.1038/nm.3040.
Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.
Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ. Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development. Circulation Research 2013, 113: 22-31. PMID: 23603510, PMCID: PMC3739451, DOI: 10.1161/CIRCRESAHA.113.301324.
Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis.
Chun HJ, Ali ZA, Kojima Y, Kundu RK, Sheikh AY, Agrawal R, Zheng L, Leeper NJ, Pearl NE, Patterson AJ, Anderson JP, Tsao PS, Lenardo MJ, Ashley EA, Quertermous T. Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. The Journal Of Clinical Investigation 2008, 118: 3343-54. PMID: 18769630, PMCID: PMC2525695, DOI: 10.1172/JCI34871.
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency.
Chun HJ, Zheng L, Ahmad M, Wang J, Speirs CK, Siegel RM, Dale JK, Puck J, Davis J, Hall CG, Skoda-Smith S, Atkinson TP, Straus SE, Lenardo MJ. Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature 2002, 419: 395-9. PMID: 12353035, DOI: 10.1038/nature01063.
A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.
Chan FK, Chun HJ, Zheng L, Siegel RM, Bui KL, Lenardo MJ. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science (New York, N.Y.) 2000, 288: 2351-4. PMID: 10875917.
NF-AT-Driven interleukin-4 transcription potentiated by NIP45.
Hodge MR, Chun HJ, Rengarajan J, Alt A, Lieberson R, Glimcher LH. NF-AT-Driven interleukin-4 transcription potentiated by NIP45. Science (New York, N.Y.) 1996, 274: 1903-5. PMID: 8943202.

Patient Care Organizations

View Academic Profile

Click here to view more about this specialist's research and educational efforts on https://medicine.yale.edu

Click here to view more about this specialist's research and educational efforts onhttps://medicine.yale.edu

Titles

Associate Professor
Director of Translational Research, Yale Pulmonary Vascular Disease Program, Internal Medicine
Co-Director of the Vascular Research T32 Training Program, Internal Medicine
Leadership Committee, 3CPR Council

Education & Training

Visiting Scholar
University of Cambridge (2017)
Chief Fellow
Stanford University (2009)
Fellowship
Stanford University (2009)
Residency
Stanford University (2004)
MD
Johns Hopkins University School of Medicine (2002)
Cloisters Scholar
HHMI (2001)
BA
Harvard University, Biochemical Sciences (1995)

Languages Spoken

English
한국어 (Korean)

Additional Information

Professional Service

Publications

Hospitalisation among vaccine breakthrough COVID-19 infections.
Juthani PV, Gupta A, Borges KA, Price CC, Lee AI, Won CH, Chun HJ. Hospitalisation among vaccine breakthrough COVID-19 infections. The Lancet. Infectious Diseases 2021, 21: 1485-1486. PMID: 34506735, PMCID: PMC8423430, DOI: 10.1016/S1473-3099(21)00558-2.
Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study.
Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI. Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. The Lancet. Haematology 2020, 7: e575-e582. PMID: 32619411, PMCID: PMC7326446, DOI: 10.1016/S2352-3026(20)30216-7.
A neutrophil activation signature predicts critical illness and mortality in COVID-19.
Meizlish ML, Pine AB, Bishai JD, Goshua G, Nadelmann ER, Simonov M, Chang CH, Zhang H, Shallow M, Bahel P, Owusu K, Yamamoto Y, Arora T, Atri DS, Patel A, Gbyli R, Kwan J, Won CH, Dela Cruz C, Price C, Koff J, King BA, Rinder HM, Wilson FP, Hwa J, Halene S, Damsky W, van Dijk D, Lee AI, Chun HJ. A neutrophil activation signature predicts critical illness and mortality in COVID-19. Blood Advances 2021, 5: 1164-1177. PMID: 33635335, PMCID: PMC7908851, DOI: 10.1182/bloodadvances.2020003568.
Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection.
Chun HJ, Coutavas E, Pine AB, Lee AI, Yu VL, Shallow MK, Giovacchini CX, Mathews AM, Stephenson B, Que LG, Lee PJ, Kraft BD. Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection. JCI Insight 2021, 6 PMID: 34111030, PMCID: PMC8410030, DOI: 10.1172/jci.insight.148476.
Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects.
Hwangbo C, Wu J, Papangeli I, Adachi T, Sharma B, Park S, Zhao L, Ju H, Go GW, Cui G, Inayathullah M, Job JK, Rajadas J, Kwei SL, Li MO, Morrison AR, Quertermous T, Mani A, Red-Horse K, Chun HJ. Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects. Science Translational Medicine 2017, 9 PMID: 28904225, PMCID: PMC5703224, DOI: 10.1126/scitranslmed.aad4000.
MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation.
Papangeli I, Kim J, Maier I, Park S, Lee A, Kang Y, Tanaka K, Khan OF, Ju H, Kojima Y, Red-Horse K, Anderson DG, Siekmann AF, Chun HJ. MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation. Nature Communications 2016, 7: 11268. PMID: 27068353, PMCID: PMC4832062, DOI: 10.1038/ncomms11268.
Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension.
Kim J, Hwangbo C, Hu X, Kang Y, Papangeli I, Mehrotra D, Park H, Ju H, McLean DL, Comhair SA, Erzurum SC, Chun HJ. Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension. Circulation 2015, 131: 190-9. PMID: 25336633, PMCID: PMC4293354, DOI: 10.1161/CIRCULATIONAHA.114.013339.
An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension.
Kim J, Kang Y, Kojima Y, Lighthouse JK, Hu X, Aldred MA, McLean DL, Park H, Comhair SA, Greif DM, Erzurum SC, Chun HJ. An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension. Nature Medicine 2013, 19: 74-82. PMID: 23263626, PMCID: PMC3540168, DOI: 10.1038/nm.3040.
Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.
Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ. Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development. Circulation Research 2013, 113: 22-31. PMID: 23603510, PMCID: PMC3739451, DOI: 10.1161/CIRCRESAHA.113.301324.
Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis.
Chun HJ, Ali ZA, Kojima Y, Kundu RK, Sheikh AY, Agrawal R, Zheng L, Leeper NJ, Pearl NE, Patterson AJ, Anderson JP, Tsao PS, Lenardo MJ, Ashley EA, Quertermous T. Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. The Journal Of Clinical Investigation 2008, 118: 3343-54. PMID: 18769630, PMCID: PMC2525695, DOI: 10.1172/JCI34871.
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency.
Chun HJ, Zheng L, Ahmad M, Wang J, Speirs CK, Siegel RM, Dale JK, Puck J, Davis J, Hall CG, Skoda-Smith S, Atkinson TP, Straus SE, Lenardo MJ. Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature 2002, 419: 395-9. PMID: 12353035, DOI: 10.1038/nature01063.
A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.
Chan FK, Chun HJ, Zheng L, Siegel RM, Bui KL, Lenardo MJ. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science (New York, N.Y.) 2000, 288: 2351-4. PMID: 10875917.
NF-AT-Driven interleukin-4 transcription potentiated by NIP45.
Hodge MR, Chun HJ, Rengarajan J, Alt A, Lieberson R, Glimcher LH. NF-AT-Driven interleukin-4 transcription potentiated by NIP45. Science (New York, N.Y.) 1996, 274: 1903-5. PMID: 8943202.

Patient Care Organizations

Heart and Vascular
Yale Physicians Building
800 Howard Avenue, Fl 2
New Haven, CT 06519
- Directions