Mehran M Sadeghi, MD
Cardiovascular Medicine
Biography
Mehran Sadeghi, MD, is a cardiologist who treats patients at Yale New Haven Hospital and the VA Medical Center.
He is the principal investigator of the Cardiovascular Molecular Imaging Laboratory, which aims to develop new imaging techniques to visualize, characterize, and quantify molecular and cellular processes involved in cardiovascular diseases. Dr. Sadeghi and his lab focus their research on vascular remodeling, fibrosis, inflammation, aneurysms, cardiomyopathy, and aortic valve disease.
Dr. Sadeghi is a recipient of the Hermann Blumgart Award from the Society of Nuclear Medicine and Molecular Imaging. He is also a member of the American College of Cardiology, the Society of Nuclear Medicine and Molecular Imaging, and the American Society of Nuclear Cardiology.
He is a professor of medicine (cardiology) at Yale School of Medicine.
Titles
- Professor
Education & Training
- Cardiology, Nuclear Cardiology and Vascular Biology FellowYale University (2000)
- ResidentYale-New Haven Hospital (1995)
- MDNecker-Enfants Malades (1991)
Languages Spoken
- English
- Fārsī (Farsi)
- Français (French)
Additional Information
Honors & Recognitions
- Hermann Blumgart Award: Cardiovascular Council, Society of Nuclear Medicine and Molecular Imaging (2012)
Publications
- Chan P, Sadeghi M. Psychological stress and vessel wall inflammation: Opportunity of reducing cardiovascular risk in people with HIV. Brain Behavior And Immunity 2023, 115: 118-119. PMID: 37820976, DOI: 10.1016/j.bbi.2023.10.007.
- Ahmad A, Ghim M, Toczek J, Neishabouri A, Ojha D, Zhang Z, Gona K, Raza M, Jung J, Kukreja G, Zhang J, Guerrera N, Liu C, Sadeghi M. Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve. Journal Of Nuclear Medicine 2023, 64: 1487-1494. PMID: 37321825, PMCID: PMC10478817, DOI: 10.2967/jnumed.123.265516.
- Bellamkonda K, Zogg C, Nassiri N, Sadeghi M, Zhang Y, Guzman R, Chaar C. Characteristics and 1-year outcomes of patients with rupture of small abdominal aortic aneurysms. European Journal Of Vascular And Endovascular Surgery 2023, 65: e108. DOI: 10.1016/j.ejvs.2023.05.022.
- Stendahl J, Kwan J, Pucar D, Sadeghi M. Radiotracers to address unmet clinical needs in cardiovascular imaging, part 2: inflammation, fibrosis, thrombosis, calcification, and amyloidosis imaging. Chinese Journal Of Nuclear Medicine And Molecular Imaging 2023, 43: 187-192. DOI: 10.3760/cma.j.cn321828-20221103-00333.
- Stendahl J, Kwan J, Pucar D, Sadeghi M. Radiotracers to address unmet clinical needs in cardiovascular imaging, part 1: technical considerations and perfusion and neuronal imaging. Chinese Journal Of Nuclear Medicine And Molecular Imaging 2023, 43: 122-128. DOI: 10.3760/cma.j.cn321828-20221009-00301.
- Bellamkonda K, Zogg C, Nassiri N, Sadeghi M, Zhang Y, Guzman R, Ochoa Chaar C. Characteristics and 1-year outcomes of patients with rupture of small abdominal aortic aneurysms. Journal Of Vascular Surgery 2023, 77: 1649-1657. PMID: 36796595, DOI: 10.1016/j.jvs.2023.02.003.
- Salarian M, Ghim M, Toczek J, Han J, Weiss D, Spronck B, Ramachandra A, Jung J, Kukreja G, Zhang J, Lakheram D, Kim S, Humphrey J, Sadeghi M. Homeostatic, Non-Canonical Role of Macrophage Elastase in Vascular Integrity. Circulation Research 2023, 132: 432-448. PMID: 36691905, PMCID: PMC9930896, DOI: 10.1161/circresaha.122.322096.
- Toczek J, Gona K, Liu Y, Ahmad A, Ghim M, Ojha D, Kukreja G, Salarian M, Luehmann H, Heo G, Guzman R, Chaar C, Tellides G, Hassab A, Ye Y, Shoghi K, Zayed M, Gropler R, Sadeghi M. Positron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm. Circulation Cardiovascular Imaging 2023, 16: e014615. PMID: 36649454, PMCID: PMC9858355, DOI: 10.1161/circimaging.122.014615.
- Sadeghi MM. Beyond perfusion imaging. Journal Of Nuclear Cardiology 2022, 29: 1485-1486. PMID: 35790690, DOI: 10.1007/s12350-022-03050-0.
- Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 2: Inflammation, Fibrosis, Thrombosis, Calcification, and Amyloidosis Imaging. Journal Of Nuclear Medicine 2022, 63: 986-994. PMID: 35772956, PMCID: PMC9258561, DOI: 10.2967/jnumed.121.263507.
- Spronck B, Ramachandra AB, Moriyama L, Toczek J, Han J, Sadeghi MM, Humphrey JD. Deletion of matrix metalloproteinase-12 compromises mechanical homeostasis and leads to an aged aortic phenotype in young mice. Journal Of Biomechanics 2022, 141: 111179. PMID: 35759974, PMCID: PMC9585962, DOI: 10.1016/j.jbiomech.2022.111179.
- Zhang X, Rotllan N, Canfrán-Duque A, Sun J, Toczek J, Moshnikova A, Malik S, Price NL, Araldi E, Zhong W, Sadeghi MM, Andreev OA, Bahal R, Reshetnyak YK, Suárez Y, Fernández-Hernando C. Targeted Suppression of miRNA-33 Using pHLIP Improves Atherosclerosis Regression. Circulation Research 2022, 131: 77-90. PMID: 35534923, PMCID: PMC9640270, DOI: 10.1161/circresaha.121.320296.
- Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging. Journal Of Nuclear Medicine 2022, 63: 649-658. PMID: 35487563, DOI: 10.2967/jnumed.121.263506.
- Jung JJ, Ahmad AA, Rajendran S, Wei L, Zhang J, Toczek J, Nie L, Kukreja G, Salarian M, Gona K, Ghim M, Chakraborty R, Martin KA, Tellides G, Heistad D, Sadeghi MM. Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification. JACC Basic To Translational Science 2022, 7: 333-345. PMID: 35540096, PMCID: PMC9079798, DOI: 10.1016/j.jacbts.2021.12.006.
- Coppo R, Orso F, Virga F, Dalmasso A, Baruffaldi D, Nie L, Clapero F, Dettori D, Quirico L, Grassi E, Defilippi P, Provero P, Valdembri D, Serini G, Sadeghi MM, Mazzone M, Taverna D. ESDN inhibits melanoma progression by blocking E-selectin expression in endothelial cells via STAT3. Cancer Letters 2021, 510: 13-23. PMID: 33862151, PMCID: PMC8581997, DOI: 10.1016/j.canlet.2021.04.005.
- Dorbala S, Zhou W, Sadeghi M. Advancing the mission of cardiovascular molecular imaging. Journal Of Nuclear Cardiology 2021, 30: 2266-2267. PMID: 33655449, PMCID: PMC7924910, DOI: 10.1007/s12350-021-02534-9.
- Bellamkonda K, Nassiri N, Sadeghi MM, Zhang Y, Guzman RJ, Ochoa Chaar CI. Characteristics and outcomes of small abdominal aortic aneurysm rupture in the American College of Surgeons National Surgical Quality Improvement Program database. Journal Of Vascular Surgery 2021, 74: 729-737. PMID: 33617982, DOI: 10.1016/j.jvs.2021.01.063.
- Toczek J, Boodagh P, Sanzida N, Ghim M, Salarian M, Gona K, Kukreja G, Rajendran S, Wei L, Han J, Zhang J, Jung JJ, Graham M, Liu X, Sadeghi MM. Computed tomography imaging of macrophage phagocytic activity in abdominal aortic aneurysm. Theranostics 2021, 11: 5876-5888. PMID: 33897887, PMCID: PMC8058712, DOI: 10.7150/thno.55106.
- Gona K, Toczek J, Ye Y, Sanzida N, Golbazi A, Boodagh P, Salarian M, Jung JJ, Rajendran S, Kukreja G, Wu TL, Devel L, Sadeghi MM. Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging. Journal Of Medicinal Chemistry 2020, 63: 15037-15049. PMID: 33206510, PMCID: PMC8010999, DOI: 10.1021/acs.jmedchem.0c01514.
- Sadeghi MM. 2020 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging. Journal Of Nuclear Medicine 2020, 61: 15n-22n. PMID: 33139397.
- Bellamkonda K, Nassiri N, Sadeghi M, Zhang Y, Guzman R, Chaar C. Characteristics and Outcomes of Ruptured Abdominal Aortic Aneurysms Below the Size Threshold for Elective Repair. Journal Of Vascular Surgery 2020, 72: e289-e290. DOI: 10.1016/j.jvs.2020.06.041.
- Bellamkonda K, Nassiri N, Sadeghi M, Zhang Y, Guzman R, Chaar C. Characteristics and Outcomes of Ruptured Abdominal Aortic Aneurysms Below the Size Threshold for Elective Repair. Journal Of Vascular Surgery 2020, 72: e195-e196. DOI: 10.1016/j.jvs.2020.04.337.
- Pucar D, Sadeghi MM. 18F-Fluorodeoxyglucose PET imaging in aortic graft infection: many more questions than answers. Journal Of Nuclear Cardiology 2020, 28: 1017-1020. PMID: 32607838, PMCID: PMC7772274, DOI: 10.1007/s12350-020-02248-4.
- Toczek J, Wu J, Hillmer AT, Han J, Esterlis I, Cosgrove KP, Liu C, Sadeghi MM. Accuracy of arterial [18F]-Fluorodeoxyglucose uptake quantification: A kinetic modeling study. Journal Of Nuclear Cardiology 2020, 27: 1578-1581. PMID: 32043239, PMCID: PMC7415600, DOI: 10.1007/s12350-020-02055-x.
- Sadeghi MM. 2019 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging. Journal Of Nuclear Medicine 2019, 60: 7n-13n. PMID: 31792135.
- Price NL, Miguel V, Ding W, Singh AK, Malik S, Rotllan N, Moshnikova A, Toczek J, Zeiss C, Sadeghi MM, Arias N, Baldán Á, Andreev OA, Rodríguez-Puyol D, Bahal R, Reshetnyak YK, Suárez Y, Fernández-Hernando C, Lamas S. Genetic deficiency or pharmacological inhibition of miR-33 protects from kidney fibrosis. JCI Insight 2019, 4 PMID: 31613798, PMCID: PMC6948871, DOI: 10.1172/jci.insight.131102.
- Toczek J, Bordenave T, Gona K, Kim HY, Beau F, Georgiadis D, Correia I, Ye Y, Razavian M, Jung J, Lequin O, Dive V, Sadeghi MM, Devel L. Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging. Journal Of Medicinal Chemistry 2019, 62: 9743-9752. PMID: 31603669, PMCID: PMC7054845, DOI: 10.1021/acs.jmedchem.9b01186.
- Salarian M, Sadeghi MM. Hype or Hope. Circulation Cardiovascular Imaging 2019, 12: e009591. PMID: 31382767, PMCID: PMC6788767, DOI: 10.1161/circimaging.119.009591.
- Toczek J, Hillmer AT, Han J, Liu C, Peters D, Emami H, Wu J, Esterlis I, Cosgrove KP, Sadeghi MM. FDG PET imaging of vascular inflammation in post-traumatic stress disorder: A pilot case–control study. Journal Of Nuclear Cardiology 2019, 28: 688-694. PMID: 31073848, PMCID: PMC6842076, DOI: 10.1007/s12350-019-01724-w.
- Malm BJ, He BJ, Carino M, Sadeghi MM. Reply to letter to the editor regarding “prevalence and variability in reporting of clinically actionable incidental findings on attenuation-correction CT scans in a veteran population”. Journal Of Nuclear Cardiology 2019, 27: 1054. PMID: 30825113, DOI: 10.1007/s12350-019-01667-2.
- Chen K, Miller EJ, Sadeghi MM. PET-Based Imaging of Ischemic Heart Disease. PET Clinics 2019, 14: 211-221. PMID: 30826019, PMCID: PMC6426655, DOI: 10.1016/j.cpet.2018.12.003.
- Tavakoli S, Sadeghi MM. 18F-Sodium Fluoride Positron Emission Tomography and Plaque Calcification. Circulation Cardiovascular Imaging 2019, 12: e008712. PMID: 30642218, PMCID: PMC6338233, DOI: 10.1161/circimaging.118.008712.
- Spronck B, Ramachandra A, Toczek J, Han J, Sadeghi M, Humphrey J. 2.1 Knock-Out of Matrix Metalloproteinase-12 Exacerbates Compromised Mechanical Homeostasis in Arterial Aging. Artery Research 2018, 24: 69-69. DOI: 10.1016/j.artres.2018.10.024.
- Sadeghi MM. 2018 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging. Journal Of Nuclear Medicine 2018, 59: 9n-15n. PMID: 30181235.
- Ye Y, Toczek J, Gona K, Kim HY, Han J, Razavian M, Golestani R, Zhang J, Wu TL, Ghosh M, Jung JJ, Sadeghi MM. Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, 99mTc-labeling, and Evaluation. Scientific Reports 2018, 8: 11647. PMID: 30076321, PMCID: PMC6076275, DOI: 10.1038/s41598-018-29941-2.
- He BJ, Malm BJ, Carino M, Sadeghi MM. Prevalence and variability in reporting of clinically actionable incidental findings on attenuation-correction CT scans in a veteran population. Journal Of Nuclear Cardiology 2018, 26: 1688-1693. PMID: 29492838, DOI: 10.1007/s12350-018-1232-9.
- Jung JJ, Jadbabaie F, Sadeghi MM. Molecular imaging of calcific aortic valve disease. Journal Of Nuclear Cardiology 2018, 25: 1148-1155. PMID: 29359271, PMCID: PMC6054901, DOI: 10.1007/s12350-017-1158-7.
- Iskandrian AE, Dilsizian V, Garcia EV, Beanlands RS, Cerqueira M, Soman P, Berman DS, Cuocolo A, Einstein AJ, Morgan CJ, Hage FG, Schelbert HR, Bax JJ, Wu JC, Shaw LJ, Sadeghi MM, Tamaki N, Kaufmann PA, Gropler R, Dorbala S, Van Decker W. Myocardial perfusion imaging: Lessons learned and work to be done—update. Journal Of Nuclear Cardiology 2017, 25: 39-52. PMID: 29110288, DOI: 10.1007/s12350-017-1093-7.
- Tavakoli S, Downs K, Short JD, Nguyen HN, Lai Y, Jerabek PA, Goins B, Toczek J, Sadeghi MM, Asmis R. Characterization of Macrophage Polarization States Using Combined Measurement of 2-Deoxyglucose and Glutamine Accumulation. Arteriosclerosis Thrombosis And Vascular Biology 2017, 37: 1840-1848. PMID: 28798141, PMCID: PMC8036006, DOI: 10.1161/atvbaha.117.308848.
- Chareonthaitawee P, Beanlands RS, Chen W, Dorbala S, Miller EJ, Murthy VL, Birnie DH, Chen ES, Cooper LT, Tung RH, White ES, Borges-Neto S, Di Carli MF, Gropler RJ, Ruddy TD, Schindler TH, Blankstein R, GROUP N, Bateman T, Cerqueira M, Dilsizian V, Heller G, Moller D, Osborne M, Sadeghi M, Soman P. Joint SNMMI–ASNC Expert Consensus Document on the Role of 18F-FDG PET/CT in Cardiac Sarcoid Detection and Therapy Monitoring. Journal Of Nuclear Medicine 2017, 58: 1341-1353. PMID: 28765228, PMCID: PMC6944184, DOI: 10.2967/jnumed.117.196287.
- Malm BJ, Sadeghi MM. Multi-modality molecular imaging of aortic aneurysms. Journal Of Nuclear Cardiology 2017, 24: 1239-1245. PMID: 28447279, PMCID: PMC7720418, DOI: 10.1007/s12350-017-0883-2.
- Toczek J, Ye Y, Gona K, Kim HY, Han J, Razavian M, Golestani R, Zhang J, Wu TL, Jung JJ, Sadeghi MM. Preclinical Evaluation of RYM1, a Matrix Metalloproteinase–Targeted Tracer for Imaging Aneurysm. Journal Of Nuclear Medicine 2017, 58: 1318-1323. PMID: 28360209, PMCID: PMC5537616, DOI: 10.2967/jnumed.116.188656.
- Razavian M, Bordenave T, Georgiadis D, Beau F, Zhang J, Golestani R, Toczek J, Jung JJ, Ye Y, Kim HY, Han J, Dive V, Devel L, Sadeghi MM. Optical imaging of MMP-12 active form in inflammation and aneurysm. Scientific Reports 2016, 6: 38345. PMID: 27917892, PMCID: PMC5137160, DOI: 10.1038/srep38345.
- Tavakoli S, Short JD, Downs K, Nguyen HN, Lai Y, Zhang W, Jerabek P, Goins B, Sadeghi MM, Asmis R. Differential Regulation of Macrophage Glucose Metabolism by Macrophage Colony-stimulating Factor and Granulocyte-Macrophage Colony-stimulating Factor: Implications for 18F FDG PET Imaging of Vessel Wall Inflammation. Radiology 2016, 283: 87-97. PMID: 27849433, PMCID: PMC5375627, DOI: 10.1148/radiol.2016160839.
- Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi M, Bender JR, Morrison AR. Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1&bgr; Production. Arteriosclerosis Thrombosis And Vascular Biology 2016, 37: 328-340. PMID: 27834690, PMCID: PMC5269510, DOI: 10.1161/atvbaha.116.308507.
- Bordenave T, Helle M, Beau F, Georgiadis D, Tepshi L, Bernes M, Ye Y, Levenez L, Poquet E, Nozach H, Razavian M, Toczek J, Stura EA, Dive V, Sadeghi MM, Devel L. Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes. Bioconjugate Chemistry 2016, 27: 2407-2417. PMID: 27564088, PMCID: PMC5100701, DOI: 10.1021/acs.bioconjchem.6b00377.
- Jung JJ, Razavian M, Kim HY, Ye Y, Golestani R, Toczek J, Zhang J, Sadeghi MM. Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice. Scientific Reports 2016, 6: 32659. PMID: 27619752, PMCID: PMC5020643, DOI: 10.1038/srep32659.
- Golestani R, Razavian M, Ye Y, Zhang J, Jung JJ, Toczek J, Gona K, Kim HY, Elias JA, Lee CG, Homer RJ, Sadeghi MM. Matrix Metalloproteinase–Targeted Imaging of Lung Inflammation and Remodeling. Journal Of Nuclear Medicine 2016, 58: 138-143. PMID: 27469361, PMCID: PMC5209638, DOI: 10.2967/jnumed.116.176198.
- Golestani R, Jung JJ, Sadeghi MM. Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology. Journal Of Clinical Medicine 2016, 5: 57. PMID: 27275836, PMCID: PMC4929412, DOI: 10.3390/jcm5060057.
- Ceneri N, Zhao L, Young B, Healy A, Coskun S, Vasavada H, Yarovinsky T, Ike K, Qin L, Pardi R, Meadows J, Tellides G, Hirschi K, Soufer R, Sadeghi M, Bender J, Morrison A. Abstract 655: Rac2 is a Key Modulator of IL-1β -dependent Atherosclerotic Plaque Calcification. Arteriosclerosis Thrombosis And Vascular Biology 2016, 36 DOI: 10.1161/atvb.36.suppl_1.655.
- Zhao L, Healy A, Ceneri N, Bailey G, Meadows J, Sadeghi M, Morrison A. Abstract 650: Statins Modulate Rac-dependent IL-1 beta Expression to Influence Calcium Composition. Arteriosclerosis Thrombosis And Vascular Biology 2016, 36 DOI: 10.1161/atvb.36.suppl_1.650.
- Toczek J, Sadeghi MM. A New Tracer for Imaging Atherosclerosis. Circulation Cardiovascular Imaging 2016, 9: e004889. PMID: 27162132, DOI: 10.1161/circimaging.116.004889.
- Li X, Jung JJ, Nie L, Razavian M, Zhang J, Samuel V, Sadeghi MM. The neuropilin-like protein ESDN regulates insulin signaling and sensitivity. AJP Heart And Circulatory Physiology 2016, 310: h1184-h1193. PMID: 26921437, PMCID: PMC4867389, DOI: 10.1152/ajpheart.00782.2015.
- Toczek J, Sadeghi MM. Molecular imaging concepts. Journal Of Nuclear Cardiology 2016, 23: 271-273. PMID: 26809440, PMCID: PMC4807131, DOI: 10.1007/s12350-016-0403-9.
- Toczek J, Meadows JL, Sadeghi MM. Novel Molecular Imaging Approaches to Abdominal Aortic Aneurysm Risk Stratification. Circulation Cardiovascular Imaging 2016, 9: e003023. PMID: 26763279, PMCID: PMC4714781, DOI: 10.1161/circimaging.115.003023.
- Sadeghi MM. Molecular cardiovascular imaging is ready for prime time: almost there. Journal Of Nuclear Cardiology 2015, 23: 67-70. PMID: 26542993, DOI: 10.1007/s12350-015-0237-x.
- Zhou J, Qin L, Yi T, Ali R, Li Q, Jiao Y, Li G, Tobiasova Z, Huang Y, Zhang J, Yun JJ, Sadeghi MM, Giordano FJ, Pober JS, Tellides G. Interferon-&ggr;–Mediated Allograft Rejection Exacerbates Cardiovascular Disease of Hyperlipidemic Murine Transplant Recipients. Circulation Research 2015, 117: 943-955. PMID: 26399469, PMCID: PMC4636943, DOI: 10.1161/circresaha.115.306932.
- Zhou J, Qin L, Yi T, Ali R, Li Q, Jiao Y, Li G, Zhang J, Sadeghi M, Pober J, Tellides G. Abstract 219: IFN-γ Plays an Essential Role in Accelerating Cardiovascular Disease of Recipients With MHC Class II-mismatched Allografts. Arteriosclerosis Thrombosis And Vascular Biology 2015, 35 DOI: 10.1161/atvb.35.suppl_1.219.
- Ceneri N, Young B, Yarovinsky T, Sadeghi M, Bender J, Morrison A. Abstract 142: Rac2 Modulates Macrophage IL-1β Production, Atherosclerotic Plaque Inflammation, and Calcific Atherosclerosis. Arteriosclerosis Thrombosis And Vascular Biology 2015, 35 DOI: 10.1161/atvb.35.suppl_1.142.
- Zhou J, yi T, Qin L, Ali R, Li Q, Jiao Y, Li G, Zhang J, Sadeghi M, Pober J, Tellides G. MHC class II-disparate heart but not skin allografts accelerate recipient cardiovascular disease (TRAN1P.934). The Journal Of Immunology 2015, 194: 140.16-140.16. DOI: 10.4049/jimmunol.194.supp.140.16.
- Jung JJ, Razavian M, Challa AA, Nie L, Golestani R, Zhang J, Ye Y, Russell KS, Robinson SP, Heistad DD, Sadeghi MM. Multimodality and Molecular Imaging of Matrix Metalloproteinase Activation in Calcific Aortic Valve Disease. Journal Of Nuclear Medicine 2015, 56: 933-938. PMID: 25908827, PMCID: PMC4454445, DOI: 10.2967/jnumed.114.152355.
- Sadeghi MM. 18F-FDG PET and vascular inflammation: Time to refine the paradigm? Journal Of Nuclear Cardiology 2015, 22: 319-324. PMID: 24925623, PMCID: PMC4265310, DOI: 10.1007/s12350-014-9917-1.
- Sadeghi MM, Wu JC. Cardiovascular molecular imaging: Expanding the paradigms and parameters. Journal Of Nuclear Cardiology 2015, 22: 401-402. PMID: 25809082, PMCID: PMC4807129, DOI: 10.1007/s12350-015-0110-y.
- Chapter 9: Cardiovascular Molecular ImagingMorrison A, Wu JC, Sadeghi MM: Nuclear Cardiac Imaging: Principles and Applications, 5th Edition. Oxford University Press. New York, NY. Ed. Iskandrian A and Garcia E. 2015: Ch. 29, 601-36.
- Golestani R, Razavian M, Nie L, Zhang J, Jung JJ, Ye Y, de Roo M, Hilgerink K, Liu C, Robinson SP, Sadeghi MM. Imaging Vessel Wall Biology to Predict Outcome in Abdominal Aortic Aneurysm. Circulation Cardiovascular Imaging 2014, 8: &na;. PMID: 25550400, PMCID: PMC4284949, DOI: 10.1161/circimaging.114.002471.
- Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E. Calcific Aortic Valve Disease. Arteriosclerosis Thrombosis And Vascular Biology 2014, 34: 2387-2393. PMID: 25189570, PMCID: PMC4199903, DOI: 10.1161/atvbaha.114.302523.
- Tavakoli S, Vashist A, Sadeghi MM. Molecular imaging of plaque vulnerability. Journal Of Nuclear Cardiology 2014, 21: 1112-1128. PMID: 25124827, PMCID: PMC4229449, DOI: 10.1007/s12350-014-9959-4.
- Zhou J, Qin L, Yi T, Ali R, Li Q, Jiao Y, Li G, Tobiasova Z, Huang Y, Zhang J, Sadeghi M, Giordano F, Pober J, Tellides G. Abstract 155: Sustained CD4+ T-Cell Activation Promotes Transplant-Associated Recipient Cardiovascular Disease. Arteriosclerosis Thrombosis And Vascular Biology 2014, 34 DOI: 10.1161/atvb.34.suppl_1.155.
- Marfatia R, Tavakoli S, Sadeghi M. Applications of Molecular Small-Animal Imaging in Cardiology. 2014, 547-584. DOI: 10.1007/978-1-4939-0894-3_20.
- Applications of Molecular Small-Animal Imaging in CardiologyMarfatia R, Tavakoli S, Sadeghi MM: Multimodality Molecular Imaging of Small Animals. Springer Science+Business Media New York. Ed. Zaidi H. 2014: Ch. 20, 525-560.
- Golestani R, Sadeghi MM. Emergence of molecular imaging of aortic aneurysm: Implications for risk stratification and management. Journal Of Nuclear Cardiology 2014, 21: 251-267. PMID: 24381115, PMCID: PMC3991015, DOI: 10.1007/s12350-013-9845-5.
- Razavian M, Nie L, Challa A, Zhang J, Golestani R, Jung JJ, Robinson S, Sadeghi MM. Lipid lowering and imaging protease activation in atherosclerosis. Journal Of Nuclear Cardiology 2013, 21: 319-328. PMID: 24368425, PMCID: PMC3991560, DOI: 10.1007/s12350-013-9843-7.
- Nie L, Guo X, Esmailzadeh L, Zhang J, Asadi A, Collinge M, Li X, Kim JD, Woolls M, Jin SW, Dubrac A, Eichmann A, Simons M, Bender JR, Sadeghi MM. Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. Journal Of Clinical Investigation 2013, 123: 5082-5097. PMID: 24177422, PMCID: PMC3859420, DOI: 10.1172/jci67752.
- Zhang J, Razavian M, Tavakoli S, Nie L, Tellides G, Backer JM, Backer MV, Bender JR, Sadeghi MM. Molecular Imaging of Vascular Endothelial Growth Factor Receptors in Graft Arteriosclerosis. Arteriosclerosis Thrombosis And Vascular Biology 2012, 32: 1849-1855. PMID: 22723442, PMCID: PMC3401339, DOI: 10.1161/atvbaha.112.252510.
- Jane-Wit D, Sadeghi M. Molecular Imaging of Vascular Inflammation, Atherosclerosis, and Thrombosis. 2012, 129-166. DOI: 10.1007/978-1-61779-906-8_5.
- Molecular Imaging of Vascular Inflammation, Atherosclerosis, and ThrombosisJane-Wit D and Sadeghi MM: Molecular and Translational Vascular Medicine. Springer Science+Business Media New York. Ed. Homeister JW and Willis MS 2012: Ch. 5, 129-168.
- Fernandez AB, Wong TY, Klein R, Collins D, Burke G, Cotch MF, Klein B, Sadeghi MM, Chen J. Age-Related Macular Degeneration and Incident Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis. Ophthalmology 2011, 119: 765-770. PMID: 22197438, PMCID: PMC3314126, DOI: 10.1016/j.ophtha.2011.09.044.
- Razavian M, Tavakoli S, Zhang J, Nie L, Dobrucki LW, Sinusas AJ, Azure M, Robinson S, Sadeghi MM. Atherosclerosis Plaque Heterogeneity and Response to Therapy Detected by In Vivo Molecular Imaging of Matrix Metalloproteinase Activation. Journal Of Nuclear Medicine 2011, 52: 1795-1802. PMID: 21969358, PMCID: PMC3235922, DOI: 10.2967/jnumed.111.092379.
- Razavian M, Marfatia R, Mongue-Din H, Tavakoli S, Sinusas AJ, Zhang J, Nie L, Sadeghi MM. Integrin-Targeted Imaging of Inflammation in Vascular Remodeling. Arteriosclerosis Thrombosis And Vascular Biology 2011, 31: 2820-2826. PMID: 21940943, PMCID: PMC3228522, DOI: 10.1161/atvbaha.111.231654.
- Cardiovascular Council Board of Directors.. Cardiovascular nuclear imaging: balancing proven clinical value and potential radiation risk. J Nucl Med 2011, 52:1162-4.
- Tavakoli S, Razavian M, Zhang J, Nie L, Marfatia R, Dobrucki LW, Sinusas AJ, Robinson S, Edwards DS, Sadeghi MM. Matrix Metalloproteinase Activation Predicts Amelioration of Remodeling After Dietary Modification in Injured Arteries. Arteriosclerosis Thrombosis And Vascular Biology 2010, 31: 102-109. PMID: 20947820, PMCID: PMC3005135, DOI: 10.1161/atvbaha.110.216036.
- Razavian M, Zhang J, Nie L, Tavakoli S, Razavian N, Dobrucki LW, Sinusas AJ, Edwards DS, Azure M, Sadeghi MM. Molecular Imaging of Matrix Metalloproteinase Activation to Predict Murine Aneurysm Expansion In Vivo. Journal Of Nuclear Medicine 2010, 51: 1107-1115. PMID: 20554725, PMCID: PMC2908304, DOI: 10.2967/jnumed.110.075259.
- Zhang J, Silva T, Yarovinsky T, Manes TD, Tavakoli S, Nie L, Tellides G, Pober JS, Bender JR, Sadeghi MM. VEGF Blockade Inhibits Lymphocyte Recruitment and Ameliorates Immune-Mediated Vascular Remodeling. Circulation Research 2010, 107: 408-417. PMID: 20538685, PMCID: PMC2929975, DOI: 10.1161/circresaha.109.210963.
- Sadeghi MM, Glover DK, Lanza GM, Fayad ZA, Johnson LL. Imaging Atherosclerosis and Vulnerable Plaque. Journal Of Nuclear Medicine 2010, 51: 51s-65s. PMID: 20395341, PMCID: PMC2911776, DOI: 10.2967/jnumed.109.068163.
- Dobrucki LW, Meoli DF, Hu J, Sadeghi MM, Sinusas AJ. Regional hypoxia correlates with the uptake of a radiolabeled targeted marker of angiogenesis in rat model of myocardial hypertrophy and ischemic injury. Journal Of Physiology And Pharmacology 2009, 60 Suppl 4: 117-23. PMID: 20083860.
- Guo X, Nie L, Esmailzadeh L, Zhang J, Bender JR, Sadeghi MM. Endothelial and Smooth Muscle-derived Neuropilin-like Protein Regulates Platelet-derived Growth Factor Signaling in Human Vascular Smooth Muscle Cells by Modulating Receptor Ubiquitination*. Journal Of Biological Chemistry 2009, 284: 29376-29382. PMID: 19696027, PMCID: PMC2785569, DOI: 10.1074/jbc.m109.049684.
- Tavakoli S, Sadeghi M. Imaging of vascular biology in the heart. Current Cardiovascular Imaging Reports 2009, 2: 40-49. DOI: 10.1007/s12410-009-0006-9.
- Imaging of Vascular Biology in the Heart Current Cardiovascular Imaging ReportsTavakoli S, Sadeghi MM, Imaging of Vascular Biology in the Heart Current Cardiovascular Imaging Reports, 2009, 2:40-49.
- Nahrendorf M, Sosnovik DE, French BA, Swirski FK, Bengel F, Sadeghi MM, Lindner JR, Wu JC, Kraitchman DL, Fayad ZA, Sinusas AJ. Multimodality Cardiovascular Molecular Imaging, Part II. Circulation Cardiovascular Imaging 2009, 2: 56-70. PMID: 19808565, PMCID: PMC2760054, DOI: 10.1161/circimaging.108.839092.
- Zhang J, Nie L, Razavian M, Ahmed M, Dobrucki LW, Asadi A, Edwards DS, Azure M, Sinusas AJ, Sadeghi MM. Molecular Imaging of Activated Matrix Metalloproteinases in Vascular Remodeling. Circulation 2008, 118: 1953-1960. PMID: 18936327, PMCID: PMC2637824, DOI: 10.1161/circulationaha.108.789743.
- Kalinowski L, Dobrucki LW, Meoli DF, Dione DP, Sadeghi MM, Madri JA, Sinusas AJ. Targeted imaging of hypoxia-induced integrin activation in myocardium early after infarction. Journal Of Applied Physiology 2008, 104: 1504-1512. PMID: 18356482, DOI: 10.1152/japplphysiol.00861.2007.
- Sadeghi MM, Esmailzadeh L, Zhang J, Guo X, Asadi A, Krassilnikova S, Fassaei HR, Luo G, Al‐Lamki R, Takahashi T, Tellides G, Bender JR, Rodriguez ER. ESDN Is a Marker of Vascular Remodeling and Regulator of Cell Proliferation in Graft Arteriosclerosis. American Journal Of Transplantation 2007, 7: 2098-2105. PMID: 17697260, DOI: 10.1111/j.1600-6143.2007.01919.x.
- Imaging Targets in Atherosclerosis.Smith, D., Sadeghi, MM, Bender, JR: Textbook of Cardiovascular Molecular Imaging. Informa Healthcare Publishing. Ed. Sinusas A, Gropler R, Glover D, Taegtmeyer H. 2007: Ch. 18, p. 189-202.
- Sadeghi MM, Bender JR. Activated αvβ3 Integrin Targeting in Injury-Induced Vascular Remodeling. Trends In Cardiovascular Medicine 2007, 17: 5-10. PMID: 17210471, DOI: 10.1016/j.tcm.2006.07.003.
- Xu H, Zeng L, Peng H, Chen S, Jones J, Chew TL, Sadeghi MM, Kanwar YS, Danesh FR. HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced “inside-out” signaling to extracellular matrix by preventing RhoA activation. American Journal Of Physiology. Renal Physiology 2006, 291: f995-f1004. PMID: 16774905, DOI: 10.1152/ajprenal.00092.2006.
- Sadeghi MM. The pathobiology of the vessel wall: Implications for imaging. Journal Of Nuclear Cardiology 2006, 13: 402-414. PMID: 16750785, DOI: 10.1016/j.nuclcard.2006.03.012.
- Zeng L, Xu H, Chew T, Eng E, Sadeghi MM, Adler S, Kanwar YS, Danesh FR. HMG CoA reductase inhibition modulates VEGF‐induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation. The FASEB Journal 2005, 19: 1845-1847. PMID: 16160062, DOI: 10.1096/fj.05-4240fje.
- Zhang J, Krassilnikova S, Gharaei AA, Fassaei HR, Esmailzadeh L, Asadi A, Edwards DS, Harris TD, Azure M, Tellides G, Sinusas AJ, Zaret BL, Bender JR, Sadeghi MM. αvβ3‐Targeted detection of arteriopathy in transplanted human coronary arteries: an autoradiographic study. The FASEB Journal 2005, 19: 1857-1859. PMID: 16150802, DOI: 10.1096/fj.05-4130fje.
- Hua J, Dobrucki LW, Sadeghi MM, Zhang J, Bourke BN, Cavaliere P, Song J, Chow C, Jahanshad N, van Royen N, Buschmann I, Madri JA, Mendizabal M, Sinusas AJ. Noninvasive Imaging of Angiogenesis With a 99mTc-Labeled Peptide Targeted at αvβ3 Integrin After Murine Hindlimb Ischemia. Circulation 2005, 111: 3255-3260. PMID: 15956134, DOI: 10.1161/circulationaha.104.485029.
- Zhu Q, Piao D, Sadeghi M, Zhang J, Chen Y, Sinusas A. A hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models. Proceedings Of SPIE--the International Society For Optical Engineering 2005, 5690: 356-364. DOI: 10.1117/12.592603.
- Piao D, Sadeghi MM, Zhang J, Chen Y, Sinusas AJ, Zhu Q. Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models. Journal Of Biomedical Optics 2005, 10: 044010-044010-10. PMID: 16178644, DOI: 10.1117/1.1954773.
- ZENG L, XU H, CHEW TL, CHISHOLM R, SADEGHI MM, KANWAR YS, DANESH FR. Simvastatin Modulates Angiotensin II Signaling Pathway by Preventing Rac1-Mediated Upregulation of p27. Journal Of The American Society Of Nephrology 2004, 15: 1711-1720. PMID: 15213258, DOI: 10.1097/01.asn.0000129839.91567.68.
- Sadeghi MM, Krassilnikova S, Zhang J, Gharaei AA, Fassaei HR, Esmailzadeh L, Kooshkabadi A, Edwards S, Yalamanchili P, Harris TD, Sinusas AJ, Zaret BL, Bender JR. Detection of Injury-Induced Vascular Remodeling by Targeting Activated αvβ3 Integrin In Vivo. Circulation 2004, 110: 84-90. PMID: 15210600, DOI: 10.1161/01.cir.0000133319.84326.70.
- Meoli DF, Sadeghi MM, Krassilnikova S, Bourke BN, Giordano FJ, Dione DP, Su H, Edwards DS, Liu S, Harris TD, Madri JA, Zaret BL, Sinusas AJ. Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction. Journal Of Clinical Investigation 2004, 113: 1684-1691. PMID: 15199403, PMCID: PMC420502, DOI: 10.1172/jci20352.
- Sadeghi MM, Schechner JS, Krassilnikova S, Gharaei AA, Zhang J, Kirkiles-Smith N, Sinusas AJ, Zaret BL, Bender JR. Vascular cell adhesion molecule-1-targeted detection of endothelial activation in human microvasculature. Transplantation Proceedings 2004, 36: 1585-1591. PMID: 15251390, DOI: 10.1016/j.transproceed.2004.05.060.
- Hua J, Bourke B, Song J, Chow C, Sadeghi M, Cavaliere P, Hu X, Jahanshad N, Dobrucki L, VanRoyen N, Mendizabal M, Buschmann I, Sinusas A. 1116-23 Noninvasive detection of angiogenesis with a technetium-99m labeled peptide targeted at αvβ3 integrin following hindlimb ischemia. Journal Of The American College Of Cardiology 2004, 43: a25. DOI: 10.1016/s0735-1097(04)90102-7.
- Zhu Q, Piao D, Sadeghi MM, Sinusas AJ. Simultaneous optical coherence tomography imaging and beta particle detection. Optics Letters 2003, 28: 1704-6. PMID: 13677543, DOI: 10.1364/ol.28.001704.
- Tatum JL, Narula J, Bender JR, Heller G, Sadeghi MM, Strauss HW: doi:10.1067.mnc.2003.391, Journal of Nuclear Cardiology, 2003; 10(2): 234-237
- Danesh FR, Sadeghi MM, Amro N, Philips C, Zeng L, Lin S, Sahai A, Kanwar YS. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 8301-8305. PMID: 12048257, PMCID: PMC123062, DOI: 10.1073/pnas.122228799.
- Sadeghi M, Tiglio A, Sadigh K, O’Donnell L, Collinge M, Pardi R, Bender J. INHIBITION OF INTERFERON-γ–MEDIATED MICROVASCULAR ENDOTHELIAL CELL MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II GENE ACTIVATION BY HMG-COA REDUCTASE INHIBITORS1. Transplantation 2001, 71: 1262-1268. PMID: 11397960, DOI: 10.1097/00007890-200105150-00014.
- Sadeghi M, Collinge M, Pardi R, Bender J. Simvastatin Modulates Cytokine-Mediated Endothelial Cell Adhesion Molecule Induction: Involvement of an Inhibitory G Protein. The Journal Of Immunology 2000, 165: 2712-2718. PMID: 10946302, DOI: 10.4049/jimmunol.165.5.2712.
- Bender JR, Sadeghi MM, Watson C, Pfau S, Pardi R. Heterogeneous activation thresholds to cytokines in genetically distinct endothelial cells: evidence for diverse transcriptional responses. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 3994-3998. PMID: 7513430, PMCID: PMC43709, DOI: 10.1073/pnas.91.9.3994.
Departments and Programs
Biography
Mehran Sadeghi, MD, is a cardiologist who treats patients at Yale New Haven Hospital and the VA Medical Center.
He is the principal investigator of the Cardiovascular Molecular Imaging Laboratory, which aims to develop new imaging techniques to visualize, characterize, and quantify molecular and cellular processes involved in cardiovascular diseases. Dr. Sadeghi and his lab focus their research on vascular remodeling, fibrosis, inflammation, aneurysms, cardiomyopathy, and aortic valve disease.
Dr. Sadeghi is a recipient of the Hermann Blumgart Award from the Society of Nuclear Medicine and Molecular Imaging. He is also a member of the American College of Cardiology, the Society of Nuclear Medicine and Molecular Imaging, and the American Society of Nuclear Cardiology.
He is a professor of medicine (cardiology) at Yale School of Medicine.
Titles
- Professor
Education & Training
- Cardiology, Nuclear Cardiology and Vascular Biology FellowYale University (2000)
- ResidentYale-New Haven Hospital (1995)
- MDNecker-Enfants Malades (1991)
Languages Spoken
- English
- Fārsī (Farsi)
- Français (French)
Additional Information
Honors & Recognitions
- Hermann Blumgart Award: Cardiovascular Council, Society of Nuclear Medicine and Molecular Imaging (2012)
Publications
- Chan P, Sadeghi M. Psychological stress and vessel wall inflammation: Opportunity of reducing cardiovascular risk in people with HIV. Brain Behavior And Immunity 2023, 115: 118-119. PMID: 37820976, DOI: 10.1016/j.bbi.2023.10.007.
- Ahmad A, Ghim M, Toczek J, Neishabouri A, Ojha D, Zhang Z, Gona K, Raza M, Jung J, Kukreja G, Zhang J, Guerrera N, Liu C, Sadeghi M. Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve. Journal Of Nuclear Medicine 2023, 64: 1487-1494. PMID: 37321825, PMCID: PMC10478817, DOI: 10.2967/jnumed.123.265516.
- Bellamkonda K, Zogg C, Nassiri N, Sadeghi M, Zhang Y, Guzman R, Chaar C. Characteristics and 1-year outcomes of patients with rupture of small abdominal aortic aneurysms. European Journal Of Vascular And Endovascular Surgery 2023, 65: e108. DOI: 10.1016/j.ejvs.2023.05.022.
- Stendahl J, Kwan J, Pucar D, Sadeghi M. Radiotracers to address unmet clinical needs in cardiovascular imaging, part 2: inflammation, fibrosis, thrombosis, calcification, and amyloidosis imaging. Chinese Journal Of Nuclear Medicine And Molecular Imaging 2023, 43: 187-192. DOI: 10.3760/cma.j.cn321828-20221103-00333.
- Stendahl J, Kwan J, Pucar D, Sadeghi M. Radiotracers to address unmet clinical needs in cardiovascular imaging, part 1: technical considerations and perfusion and neuronal imaging. Chinese Journal Of Nuclear Medicine And Molecular Imaging 2023, 43: 122-128. DOI: 10.3760/cma.j.cn321828-20221009-00301.
- Bellamkonda K, Zogg C, Nassiri N, Sadeghi M, Zhang Y, Guzman R, Ochoa Chaar C. Characteristics and 1-year outcomes of patients with rupture of small abdominal aortic aneurysms. Journal Of Vascular Surgery 2023, 77: 1649-1657. PMID: 36796595, DOI: 10.1016/j.jvs.2023.02.003.
- Salarian M, Ghim M, Toczek J, Han J, Weiss D, Spronck B, Ramachandra A, Jung J, Kukreja G, Zhang J, Lakheram D, Kim S, Humphrey J, Sadeghi M. Homeostatic, Non-Canonical Role of Macrophage Elastase in Vascular Integrity. Circulation Research 2023, 132: 432-448. PMID: 36691905, PMCID: PMC9930896, DOI: 10.1161/circresaha.122.322096.
- Toczek J, Gona K, Liu Y, Ahmad A, Ghim M, Ojha D, Kukreja G, Salarian M, Luehmann H, Heo G, Guzman R, Chaar C, Tellides G, Hassab A, Ye Y, Shoghi K, Zayed M, Gropler R, Sadeghi M. Positron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm. Circulation Cardiovascular Imaging 2023, 16: e014615. PMID: 36649454, PMCID: PMC9858355, DOI: 10.1161/circimaging.122.014615.
- Sadeghi MM. Beyond perfusion imaging. Journal Of Nuclear Cardiology 2022, 29: 1485-1486. PMID: 35790690, DOI: 10.1007/s12350-022-03050-0.
- Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 2: Inflammation, Fibrosis, Thrombosis, Calcification, and Amyloidosis Imaging. Journal Of Nuclear Medicine 2022, 63: 986-994. PMID: 35772956, PMCID: PMC9258561, DOI: 10.2967/jnumed.121.263507.
- Spronck B, Ramachandra AB, Moriyama L, Toczek J, Han J, Sadeghi MM, Humphrey JD. Deletion of matrix metalloproteinase-12 compromises mechanical homeostasis and leads to an aged aortic phenotype in young mice. Journal Of Biomechanics 2022, 141: 111179. PMID: 35759974, PMCID: PMC9585962, DOI: 10.1016/j.jbiomech.2022.111179.
- Zhang X, Rotllan N, Canfrán-Duque A, Sun J, Toczek J, Moshnikova A, Malik S, Price NL, Araldi E, Zhong W, Sadeghi MM, Andreev OA, Bahal R, Reshetnyak YK, Suárez Y, Fernández-Hernando C. Targeted Suppression of miRNA-33 Using pHLIP Improves Atherosclerosis Regression. Circulation Research 2022, 131: 77-90. PMID: 35534923, PMCID: PMC9640270, DOI: 10.1161/circresaha.121.320296.
- Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging. Journal Of Nuclear Medicine 2022, 63: 649-658. PMID: 35487563, DOI: 10.2967/jnumed.121.263506.
- Jung JJ, Ahmad AA, Rajendran S, Wei L, Zhang J, Toczek J, Nie L, Kukreja G, Salarian M, Gona K, Ghim M, Chakraborty R, Martin KA, Tellides G, Heistad D, Sadeghi MM. Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification. JACC Basic To Translational Science 2022, 7: 333-345. PMID: 35540096, PMCID: PMC9079798, DOI: 10.1016/j.jacbts.2021.12.006.
- Coppo R, Orso F, Virga F, Dalmasso A, Baruffaldi D, Nie L, Clapero F, Dettori D, Quirico L, Grassi E, Defilippi P, Provero P, Valdembri D, Serini G, Sadeghi MM, Mazzone M, Taverna D. ESDN inhibits melanoma progression by blocking E-selectin expression in endothelial cells via STAT3. Cancer Letters 2021, 510: 13-23. PMID: 33862151, PMCID: PMC8581997, DOI: 10.1016/j.canlet.2021.04.005.
- Dorbala S, Zhou W, Sadeghi M. Advancing the mission of cardiovascular molecular imaging. Journal Of Nuclear Cardiology 2021, 30: 2266-2267. PMID: 33655449, PMCID: PMC7924910, DOI: 10.1007/s12350-021-02534-9.
- Bellamkonda K, Nassiri N, Sadeghi MM, Zhang Y, Guzman RJ, Ochoa Chaar CI. Characteristics and outcomes of small abdominal aortic aneurysm rupture in the American College of Surgeons National Surgical Quality Improvement Program database. Journal Of Vascular Surgery 2021, 74: 729-737. PMID: 33617982, DOI: 10.1016/j.jvs.2021.01.063.
- Toczek J, Boodagh P, Sanzida N, Ghim M, Salarian M, Gona K, Kukreja G, Rajendran S, Wei L, Han J, Zhang J, Jung JJ, Graham M, Liu X, Sadeghi MM. Computed tomography imaging of macrophage phagocytic activity in abdominal aortic aneurysm. Theranostics 2021, 11: 5876-5888. PMID: 33897887, PMCID: PMC8058712, DOI: 10.7150/thno.55106.
- Gona K, Toczek J, Ye Y, Sanzida N, Golbazi A, Boodagh P, Salarian M, Jung JJ, Rajendran S, Kukreja G, Wu TL, Devel L, Sadeghi MM. Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging. Journal Of Medicinal Chemistry 2020, 63: 15037-15049. PMID: 33206510, PMCID: PMC8010999, DOI: 10.1021/acs.jmedchem.0c01514.
- Sadeghi MM. 2020 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging. Journal Of Nuclear Medicine 2020, 61: 15n-22n. PMID: 33139397.
- Bellamkonda K, Nassiri N, Sadeghi M, Zhang Y, Guzman R, Chaar C. Characteristics and Outcomes of Ruptured Abdominal Aortic Aneurysms Below the Size Threshold for Elective Repair. Journal Of Vascular Surgery 2020, 72: e289-e290. DOI: 10.1016/j.jvs.2020.06.041.
- Bellamkonda K, Nassiri N, Sadeghi M, Zhang Y, Guzman R, Chaar C. Characteristics and Outcomes of Ruptured Abdominal Aortic Aneurysms Below the Size Threshold for Elective Repair. Journal Of Vascular Surgery 2020, 72: e195-e196. DOI: 10.1016/j.jvs.2020.04.337.
- Pucar D, Sadeghi MM. 18F-Fluorodeoxyglucose PET imaging in aortic graft infection: many more questions than answers. Journal Of Nuclear Cardiology 2020, 28: 1017-1020. PMID: 32607838, PMCID: PMC7772274, DOI: 10.1007/s12350-020-02248-4.
- Toczek J, Wu J, Hillmer AT, Han J, Esterlis I, Cosgrove KP, Liu C, Sadeghi MM. Accuracy of arterial [18F]-Fluorodeoxyglucose uptake quantification: A kinetic modeling study. Journal Of Nuclear Cardiology 2020, 27: 1578-1581. PMID: 32043239, PMCID: PMC7415600, DOI: 10.1007/s12350-020-02055-x.
- Sadeghi MM. 2019 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging. Journal Of Nuclear Medicine 2019, 60: 7n-13n. PMID: 31792135.
- Price NL, Miguel V, Ding W, Singh AK, Malik S, Rotllan N, Moshnikova A, Toczek J, Zeiss C, Sadeghi MM, Arias N, Baldán Á, Andreev OA, Rodríguez-Puyol D, Bahal R, Reshetnyak YK, Suárez Y, Fernández-Hernando C, Lamas S. Genetic deficiency or pharmacological inhibition of miR-33 protects from kidney fibrosis. JCI Insight 2019, 4 PMID: 31613798, PMCID: PMC6948871, DOI: 10.1172/jci.insight.131102.
- Toczek J, Bordenave T, Gona K, Kim HY, Beau F, Georgiadis D, Correia I, Ye Y, Razavian M, Jung J, Lequin O, Dive V, Sadeghi MM, Devel L. Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging. Journal Of Medicinal Chemistry 2019, 62: 9743-9752. PMID: 31603669, PMCID: PMC7054845, DOI: 10.1021/acs.jmedchem.9b01186.
- Salarian M, Sadeghi MM. Hype or Hope. Circulation Cardiovascular Imaging 2019, 12: e009591. PMID: 31382767, PMCID: PMC6788767, DOI: 10.1161/circimaging.119.009591.
- Toczek J, Hillmer AT, Han J, Liu C, Peters D, Emami H, Wu J, Esterlis I, Cosgrove KP, Sadeghi MM. FDG PET imaging of vascular inflammation in post-traumatic stress disorder: A pilot case–control study. Journal Of Nuclear Cardiology 2019, 28: 688-694. PMID: 31073848, PMCID: PMC6842076, DOI: 10.1007/s12350-019-01724-w.
- Malm BJ, He BJ, Carino M, Sadeghi MM. Reply to letter to the editor regarding “prevalence and variability in reporting of clinically actionable incidental findings on attenuation-correction CT scans in a veteran population”. Journal Of Nuclear Cardiology 2019, 27: 1054. PMID: 30825113, DOI: 10.1007/s12350-019-01667-2.
- Chen K, Miller EJ, Sadeghi MM. PET-Based Imaging of Ischemic Heart Disease. PET Clinics 2019, 14: 211-221. PMID: 30826019, PMCID: PMC6426655, DOI: 10.1016/j.cpet.2018.12.003.
- Tavakoli S, Sadeghi MM. 18F-Sodium Fluoride Positron Emission Tomography and Plaque Calcification. Circulation Cardiovascular Imaging 2019, 12: e008712. PMID: 30642218, PMCID: PMC6338233, DOI: 10.1161/circimaging.118.008712.
- Spronck B, Ramachandra A, Toczek J, Han J, Sadeghi M, Humphrey J. 2.1 Knock-Out of Matrix Metalloproteinase-12 Exacerbates Compromised Mechanical Homeostasis in Arterial Aging. Artery Research 2018, 24: 69-69. DOI: 10.1016/j.artres.2018.10.024.
- Sadeghi MM. 2018 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging. Journal Of Nuclear Medicine 2018, 59: 9n-15n. PMID: 30181235.
- Ye Y, Toczek J, Gona K, Kim HY, Han J, Razavian M, Golestani R, Zhang J, Wu TL, Ghosh M, Jung JJ, Sadeghi MM. Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, 99mTc-labeling, and Evaluation. Scientific Reports 2018, 8: 11647. PMID: 30076321, PMCID: PMC6076275, DOI: 10.1038/s41598-018-29941-2.
- He BJ, Malm BJ, Carino M, Sadeghi MM. Prevalence and variability in reporting of clinically actionable incidental findings on attenuation-correction CT scans in a veteran population. Journal Of Nuclear Cardiology 2018, 26: 1688-1693. PMID: 29492838, DOI: 10.1007/s12350-018-1232-9.
- Jung JJ, Jadbabaie F, Sadeghi MM. Molecular imaging of calcific aortic valve disease. Journal Of Nuclear Cardiology 2018, 25: 1148-1155. PMID: 29359271, PMCID: PMC6054901, DOI: 10.1007/s12350-017-1158-7.
- Iskandrian AE, Dilsizian V, Garcia EV, Beanlands RS, Cerqueira M, Soman P, Berman DS, Cuocolo A, Einstein AJ, Morgan CJ, Hage FG, Schelbert HR, Bax JJ, Wu JC, Shaw LJ, Sadeghi MM, Tamaki N, Kaufmann PA, Gropler R, Dorbala S, Van Decker W. Myocardial perfusion imaging: Lessons learned and work to be done—update. Journal Of Nuclear Cardiology 2017, 25: 39-52. PMID: 29110288, DOI: 10.1007/s12350-017-1093-7.
- Tavakoli S, Downs K, Short JD, Nguyen HN, Lai Y, Jerabek PA, Goins B, Toczek J, Sadeghi MM, Asmis R. Characterization of Macrophage Polarization States Using Combined Measurement of 2-Deoxyglucose and Glutamine Accumulation. Arteriosclerosis Thrombosis And Vascular Biology 2017, 37: 1840-1848. PMID: 28798141, PMCID: PMC8036006, DOI: 10.1161/atvbaha.117.308848.
- Chareonthaitawee P, Beanlands RS, Chen W, Dorbala S, Miller EJ, Murthy VL, Birnie DH, Chen ES, Cooper LT, Tung RH, White ES, Borges-Neto S, Di Carli MF, Gropler RJ, Ruddy TD, Schindler TH, Blankstein R, GROUP N, Bateman T, Cerqueira M, Dilsizian V, Heller G, Moller D, Osborne M, Sadeghi M, Soman P. Joint SNMMI–ASNC Expert Consensus Document on the Role of 18F-FDG PET/CT in Cardiac Sarcoid Detection and Therapy Monitoring. Journal Of Nuclear Medicine 2017, 58: 1341-1353. PMID: 28765228, PMCID: PMC6944184, DOI: 10.2967/jnumed.117.196287.
- Malm BJ, Sadeghi MM. Multi-modality molecular imaging of aortic aneurysms. Journal Of Nuclear Cardiology 2017, 24: 1239-1245. PMID: 28447279, PMCID: PMC7720418, DOI: 10.1007/s12350-017-0883-2.
- Toczek J, Ye Y, Gona K, Kim HY, Han J, Razavian M, Golestani R, Zhang J, Wu TL, Jung JJ, Sadeghi MM. Preclinical Evaluation of RYM1, a Matrix Metalloproteinase–Targeted Tracer for Imaging Aneurysm. Journal Of Nuclear Medicine 2017, 58: 1318-1323. PMID: 28360209, PMCID: PMC5537616, DOI: 10.2967/jnumed.116.188656.
- Razavian M, Bordenave T, Georgiadis D, Beau F, Zhang J, Golestani R, Toczek J, Jung JJ, Ye Y, Kim HY, Han J, Dive V, Devel L, Sadeghi MM. Optical imaging of MMP-12 active form in inflammation and aneurysm. Scientific Reports 2016, 6: 38345. PMID: 27917892, PMCID: PMC5137160, DOI: 10.1038/srep38345.
- Tavakoli S, Short JD, Downs K, Nguyen HN, Lai Y, Zhang W, Jerabek P, Goins B, Sadeghi MM, Asmis R. Differential Regulation of Macrophage Glucose Metabolism by Macrophage Colony-stimulating Factor and Granulocyte-Macrophage Colony-stimulating Factor: Implications for 18F FDG PET Imaging of Vessel Wall Inflammation. Radiology 2016, 283: 87-97. PMID: 27849433, PMCID: PMC5375627, DOI: 10.1148/radiol.2016160839.
- Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi M, Bender JR, Morrison AR. Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1&bgr; Production. Arteriosclerosis Thrombosis And Vascular Biology 2016, 37: 328-340. PMID: 27834690, PMCID: PMC5269510, DOI: 10.1161/atvbaha.116.308507.
- Bordenave T, Helle M, Beau F, Georgiadis D, Tepshi L, Bernes M, Ye Y, Levenez L, Poquet E, Nozach H, Razavian M, Toczek J, Stura EA, Dive V, Sadeghi MM, Devel L. Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes. Bioconjugate Chemistry 2016, 27: 2407-2417. PMID: 27564088, PMCID: PMC5100701, DOI: 10.1021/acs.bioconjchem.6b00377.
- Jung JJ, Razavian M, Kim HY, Ye Y, Golestani R, Toczek J, Zhang J, Sadeghi MM. Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice. Scientific Reports 2016, 6: 32659. PMID: 27619752, PMCID: PMC5020643, DOI: 10.1038/srep32659.
- Golestani R, Razavian M, Ye Y, Zhang J, Jung JJ, Toczek J, Gona K, Kim HY, Elias JA, Lee CG, Homer RJ, Sadeghi MM. Matrix Metalloproteinase–Targeted Imaging of Lung Inflammation and Remodeling. Journal Of Nuclear Medicine 2016, 58: 138-143. PMID: 27469361, PMCID: PMC5209638, DOI: 10.2967/jnumed.116.176198.
- Golestani R, Jung JJ, Sadeghi MM. Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology. Journal Of Clinical Medicine 2016, 5: 57. PMID: 27275836, PMCID: PMC4929412, DOI: 10.3390/jcm5060057.
- Ceneri N, Zhao L, Young B, Healy A, Coskun S, Vasavada H, Yarovinsky T, Ike K, Qin L, Pardi R, Meadows J, Tellides G, Hirschi K, Soufer R, Sadeghi M, Bender J, Morrison A. Abstract 655: Rac2 is a Key Modulator of IL-1β -dependent Atherosclerotic Plaque Calcification. Arteriosclerosis Thrombosis And Vascular Biology 2016, 36 DOI: 10.1161/atvb.36.suppl_1.655.
- Zhao L, Healy A, Ceneri N, Bailey G, Meadows J, Sadeghi M, Morrison A. Abstract 650: Statins Modulate Rac-dependent IL-1 beta Expression to Influence Calcium Composition. Arteriosclerosis Thrombosis And Vascular Biology 2016, 36 DOI: 10.1161/atvb.36.suppl_1.650.
- Toczek J, Sadeghi MM. A New Tracer for Imaging Atherosclerosis. Circulation Cardiovascular Imaging 2016, 9: e004889. PMID: 27162132, DOI: 10.1161/circimaging.116.004889.
- Li X, Jung JJ, Nie L, Razavian M, Zhang J, Samuel V, Sadeghi MM. The neuropilin-like protein ESDN regulates insulin signaling and sensitivity. AJP Heart And Circulatory Physiology 2016, 310: h1184-h1193. PMID: 26921437, PMCID: PMC4867389, DOI: 10.1152/ajpheart.00782.2015.
- Toczek J, Sadeghi MM. Molecular imaging concepts. Journal Of Nuclear Cardiology 2016, 23: 271-273. PMID: 26809440, PMCID: PMC4807131, DOI: 10.1007/s12350-016-0403-9.
- Toczek J, Meadows JL, Sadeghi MM. Novel Molecular Imaging Approaches to Abdominal Aortic Aneurysm Risk Stratification. Circulation Cardiovascular Imaging 2016, 9: e003023. PMID: 26763279, PMCID: PMC4714781, DOI: 10.1161/circimaging.115.003023.
- Sadeghi MM. Molecular cardiovascular imaging is ready for prime time: almost there. Journal Of Nuclear Cardiology 2015, 23: 67-70. PMID: 26542993, DOI: 10.1007/s12350-015-0237-x.
- Zhou J, Qin L, Yi T, Ali R, Li Q, Jiao Y, Li G, Tobiasova Z, Huang Y, Zhang J, Yun JJ, Sadeghi MM, Giordano FJ, Pober JS, Tellides G. Interferon-&ggr;–Mediated Allograft Rejection Exacerbates Cardiovascular Disease of Hyperlipidemic Murine Transplant Recipients. Circulation Research 2015, 117: 943-955. PMID: 26399469, PMCID: PMC4636943, DOI: 10.1161/circresaha.115.306932.
- Zhou J, Qin L, Yi T, Ali R, Li Q, Jiao Y, Li G, Zhang J, Sadeghi M, Pober J, Tellides G. Abstract 219: IFN-γ Plays an Essential Role in Accelerating Cardiovascular Disease of Recipients With MHC Class II-mismatched Allografts. Arteriosclerosis Thrombosis And Vascular Biology 2015, 35 DOI: 10.1161/atvb.35.suppl_1.219.
- Ceneri N, Young B, Yarovinsky T, Sadeghi M, Bender J, Morrison A. Abstract 142: Rac2 Modulates Macrophage IL-1β Production, Atherosclerotic Plaque Inflammation, and Calcific Atherosclerosis. Arteriosclerosis Thrombosis And Vascular Biology 2015, 35 DOI: 10.1161/atvb.35.suppl_1.142.
- Zhou J, yi T, Qin L, Ali R, Li Q, Jiao Y, Li G, Zhang J, Sadeghi M, Pober J, Tellides G. MHC class II-disparate heart but not skin allografts accelerate recipient cardiovascular disease (TRAN1P.934). The Journal Of Immunology 2015, 194: 140.16-140.16. DOI: 10.4049/jimmunol.194.supp.140.16.
- Jung JJ, Razavian M, Challa AA, Nie L, Golestani R, Zhang J, Ye Y, Russell KS, Robinson SP, Heistad DD, Sadeghi MM. Multimodality and Molecular Imaging of Matrix Metalloproteinase Activation in Calcific Aortic Valve Disease. Journal Of Nuclear Medicine 2015, 56: 933-938. PMID: 25908827, PMCID: PMC4454445, DOI: 10.2967/jnumed.114.152355.
- Sadeghi MM. 18F-FDG PET and vascular inflammation: Time to refine the paradigm? Journal Of Nuclear Cardiology 2015, 22: 319-324. PMID: 24925623, PMCID: PMC4265310, DOI: 10.1007/s12350-014-9917-1.
- Sadeghi MM, Wu JC. Cardiovascular molecular imaging: Expanding the paradigms and parameters. Journal Of Nuclear Cardiology 2015, 22: 401-402. PMID: 25809082, PMCID: PMC4807129, DOI: 10.1007/s12350-015-0110-y.
- Chapter 9: Cardiovascular Molecular ImagingMorrison A, Wu JC, Sadeghi MM: Nuclear Cardiac Imaging: Principles and Applications, 5th Edition. Oxford University Press. New York, NY. Ed. Iskandrian A and Garcia E. 2015: Ch. 29, 601-36.
- Golestani R, Razavian M, Nie L, Zhang J, Jung JJ, Ye Y, de Roo M, Hilgerink K, Liu C, Robinson SP, Sadeghi MM. Imaging Vessel Wall Biology to Predict Outcome in Abdominal Aortic Aneurysm. Circulation Cardiovascular Imaging 2014, 8: &na;. PMID: 25550400, PMCID: PMC4284949, DOI: 10.1161/circimaging.114.002471.
- Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E. Calcific Aortic Valve Disease. Arteriosclerosis Thrombosis And Vascular Biology 2014, 34: 2387-2393. PMID: 25189570, PMCID: PMC4199903, DOI: 10.1161/atvbaha.114.302523.
- Tavakoli S, Vashist A, Sadeghi MM. Molecular imaging of plaque vulnerability. Journal Of Nuclear Cardiology 2014, 21: 1112-1128. PMID: 25124827, PMCID: PMC4229449, DOI: 10.1007/s12350-014-9959-4.
- Zhou J, Qin L, Yi T, Ali R, Li Q, Jiao Y, Li G, Tobiasova Z, Huang Y, Zhang J, Sadeghi M, Giordano F, Pober J, Tellides G. Abstract 155: Sustained CD4+ T-Cell Activation Promotes Transplant-Associated Recipient Cardiovascular Disease. Arteriosclerosis Thrombosis And Vascular Biology 2014, 34 DOI: 10.1161/atvb.34.suppl_1.155.
- Marfatia R, Tavakoli S, Sadeghi M. Applications of Molecular Small-Animal Imaging in Cardiology. 2014, 547-584. DOI: 10.1007/978-1-4939-0894-3_20.
- Applications of Molecular Small-Animal Imaging in CardiologyMarfatia R, Tavakoli S, Sadeghi MM: Multimodality Molecular Imaging of Small Animals. Springer Science+Business Media New York. Ed. Zaidi H. 2014: Ch. 20, 525-560.
- Golestani R, Sadeghi MM. Emergence of molecular imaging of aortic aneurysm: Implications for risk stratification and management. Journal Of Nuclear Cardiology 2014, 21: 251-267. PMID: 24381115, PMCID: PMC3991015, DOI: 10.1007/s12350-013-9845-5.
- Razavian M, Nie L, Challa A, Zhang J, Golestani R, Jung JJ, Robinson S, Sadeghi MM. Lipid lowering and imaging protease activation in atherosclerosis. Journal Of Nuclear Cardiology 2013, 21: 319-328. PMID: 24368425, PMCID: PMC3991560, DOI: 10.1007/s12350-013-9843-7.
- Nie L, Guo X, Esmailzadeh L, Zhang J, Asadi A, Collinge M, Li X, Kim JD, Woolls M, Jin SW, Dubrac A, Eichmann A, Simons M, Bender JR, Sadeghi MM. Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. Journal Of Clinical Investigation 2013, 123: 5082-5097. PMID: 24177422, PMCID: PMC3859420, DOI: 10.1172/jci67752.
- Zhang J, Razavian M, Tavakoli S, Nie L, Tellides G, Backer JM, Backer MV, Bender JR, Sadeghi MM. Molecular Imaging of Vascular Endothelial Growth Factor Receptors in Graft Arteriosclerosis. Arteriosclerosis Thrombosis And Vascular Biology 2012, 32: 1849-1855. PMID: 22723442, PMCID: PMC3401339, DOI: 10.1161/atvbaha.112.252510.
- Jane-Wit D, Sadeghi M. Molecular Imaging of Vascular Inflammation, Atherosclerosis, and Thrombosis. 2012, 129-166. DOI: 10.1007/978-1-61779-906-8_5.
- Molecular Imaging of Vascular Inflammation, Atherosclerosis, and ThrombosisJane-Wit D and Sadeghi MM: Molecular and Translational Vascular Medicine. Springer Science+Business Media New York. Ed. Homeister JW and Willis MS 2012: Ch. 5, 129-168.
- Fernandez AB, Wong TY, Klein R, Collins D, Burke G, Cotch MF, Klein B, Sadeghi MM, Chen J. Age-Related Macular Degeneration and Incident Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis. Ophthalmology 2011, 119: 765-770. PMID: 22197438, PMCID: PMC3314126, DOI: 10.1016/j.ophtha.2011.09.044.
- Razavian M, Tavakoli S, Zhang J, Nie L, Dobrucki LW, Sinusas AJ, Azure M, Robinson S, Sadeghi MM. Atherosclerosis Plaque Heterogeneity and Response to Therapy Detected by In Vivo Molecular Imaging of Matrix Metalloproteinase Activation. Journal Of Nuclear Medicine 2011, 52: 1795-1802. PMID: 21969358, PMCID: PMC3235922, DOI: 10.2967/jnumed.111.092379.
- Razavian M, Marfatia R, Mongue-Din H, Tavakoli S, Sinusas AJ, Zhang J, Nie L, Sadeghi MM. Integrin-Targeted Imaging of Inflammation in Vascular Remodeling. Arteriosclerosis Thrombosis And Vascular Biology 2011, 31: 2820-2826. PMID: 21940943, PMCID: PMC3228522, DOI: 10.1161/atvbaha.111.231654.
- Cardiovascular Council Board of Directors.. Cardiovascular nuclear imaging: balancing proven clinical value and potential radiation risk. J Nucl Med 2011, 52:1162-4.
- Tavakoli S, Razavian M, Zhang J, Nie L, Marfatia R, Dobrucki LW, Sinusas AJ, Robinson S, Edwards DS, Sadeghi MM. Matrix Metalloproteinase Activation Predicts Amelioration of Remodeling After Dietary Modification in Injured Arteries. Arteriosclerosis Thrombosis And Vascular Biology 2010, 31: 102-109. PMID: 20947820, PMCID: PMC3005135, DOI: 10.1161/atvbaha.110.216036.
- Razavian M, Zhang J, Nie L, Tavakoli S, Razavian N, Dobrucki LW, Sinusas AJ, Edwards DS, Azure M, Sadeghi MM. Molecular Imaging of Matrix Metalloproteinase Activation to Predict Murine Aneurysm Expansion In Vivo. Journal Of Nuclear Medicine 2010, 51: 1107-1115. PMID: 20554725, PMCID: PMC2908304, DOI: 10.2967/jnumed.110.075259.
- Zhang J, Silva T, Yarovinsky T, Manes TD, Tavakoli S, Nie L, Tellides G, Pober JS, Bender JR, Sadeghi MM. VEGF Blockade Inhibits Lymphocyte Recruitment and Ameliorates Immune-Mediated Vascular Remodeling. Circulation Research 2010, 107: 408-417. PMID: 20538685, PMCID: PMC2929975, DOI: 10.1161/circresaha.109.210963.
- Sadeghi MM, Glover DK, Lanza GM, Fayad ZA, Johnson LL. Imaging Atherosclerosis and Vulnerable Plaque. Journal Of Nuclear Medicine 2010, 51: 51s-65s. PMID: 20395341, PMCID: PMC2911776, DOI: 10.2967/jnumed.109.068163.
- Dobrucki LW, Meoli DF, Hu J, Sadeghi MM, Sinusas AJ. Regional hypoxia correlates with the uptake of a radiolabeled targeted marker of angiogenesis in rat model of myocardial hypertrophy and ischemic injury. Journal Of Physiology And Pharmacology 2009, 60 Suppl 4: 117-23. PMID: 20083860.
- Guo X, Nie L, Esmailzadeh L, Zhang J, Bender JR, Sadeghi MM. Endothelial and Smooth Muscle-derived Neuropilin-like Protein Regulates Platelet-derived Growth Factor Signaling in Human Vascular Smooth Muscle Cells by Modulating Receptor Ubiquitination*. Journal Of Biological Chemistry 2009, 284: 29376-29382. PMID: 19696027, PMCID: PMC2785569, DOI: 10.1074/jbc.m109.049684.
- Tavakoli S, Sadeghi M. Imaging of vascular biology in the heart. Current Cardiovascular Imaging Reports 2009, 2: 40-49. DOI: 10.1007/s12410-009-0006-9.
- Imaging of Vascular Biology in the Heart Current Cardiovascular Imaging ReportsTavakoli S, Sadeghi MM, Imaging of Vascular Biology in the Heart Current Cardiovascular Imaging Reports, 2009, 2:40-49.
- Nahrendorf M, Sosnovik DE, French BA, Swirski FK, Bengel F, Sadeghi MM, Lindner JR, Wu JC, Kraitchman DL, Fayad ZA, Sinusas AJ. Multimodality Cardiovascular Molecular Imaging, Part II. Circulation Cardiovascular Imaging 2009, 2: 56-70. PMID: 19808565, PMCID: PMC2760054, DOI: 10.1161/circimaging.108.839092.
- Zhang J, Nie L, Razavian M, Ahmed M, Dobrucki LW, Asadi A, Edwards DS, Azure M, Sinusas AJ, Sadeghi MM. Molecular Imaging of Activated Matrix Metalloproteinases in Vascular Remodeling. Circulation 2008, 118: 1953-1960. PMID: 18936327, PMCID: PMC2637824, DOI: 10.1161/circulationaha.108.789743.
- Kalinowski L, Dobrucki LW, Meoli DF, Dione DP, Sadeghi MM, Madri JA, Sinusas AJ. Targeted imaging of hypoxia-induced integrin activation in myocardium early after infarction. Journal Of Applied Physiology 2008, 104: 1504-1512. PMID: 18356482, DOI: 10.1152/japplphysiol.00861.2007.
- Sadeghi MM, Esmailzadeh L, Zhang J, Guo X, Asadi A, Krassilnikova S, Fassaei HR, Luo G, Al‐Lamki R, Takahashi T, Tellides G, Bender JR, Rodriguez ER. ESDN Is a Marker of Vascular Remodeling and Regulator of Cell Proliferation in Graft Arteriosclerosis. American Journal Of Transplantation 2007, 7: 2098-2105. PMID: 17697260, DOI: 10.1111/j.1600-6143.2007.01919.x.
- Imaging Targets in Atherosclerosis.Smith, D., Sadeghi, MM, Bender, JR: Textbook of Cardiovascular Molecular Imaging. Informa Healthcare Publishing. Ed. Sinusas A, Gropler R, Glover D, Taegtmeyer H. 2007: Ch. 18, p. 189-202.
- Sadeghi MM, Bender JR. Activated αvβ3 Integrin Targeting in Injury-Induced Vascular Remodeling. Trends In Cardiovascular Medicine 2007, 17: 5-10. PMID: 17210471, DOI: 10.1016/j.tcm.2006.07.003.
- Xu H, Zeng L, Peng H, Chen S, Jones J, Chew TL, Sadeghi MM, Kanwar YS, Danesh FR. HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced “inside-out” signaling to extracellular matrix by preventing RhoA activation. American Journal Of Physiology. Renal Physiology 2006, 291: f995-f1004. PMID: 16774905, DOI: 10.1152/ajprenal.00092.2006.
- Sadeghi MM. The pathobiology of the vessel wall: Implications for imaging. Journal Of Nuclear Cardiology 2006, 13: 402-414. PMID: 16750785, DOI: 10.1016/j.nuclcard.2006.03.012.
- Zeng L, Xu H, Chew T, Eng E, Sadeghi MM, Adler S, Kanwar YS, Danesh FR. HMG CoA reductase inhibition modulates VEGF‐induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation. The FASEB Journal 2005, 19: 1845-1847. PMID: 16160062, DOI: 10.1096/fj.05-4240fje.
- Zhang J, Krassilnikova S, Gharaei AA, Fassaei HR, Esmailzadeh L, Asadi A, Edwards DS, Harris TD, Azure M, Tellides G, Sinusas AJ, Zaret BL, Bender JR, Sadeghi MM. αvβ3‐Targeted detection of arteriopathy in transplanted human coronary arteries: an autoradiographic study. The FASEB Journal 2005, 19: 1857-1859. PMID: 16150802, DOI: 10.1096/fj.05-4130fje.
- Hua J, Dobrucki LW, Sadeghi MM, Zhang J, Bourke BN, Cavaliere P, Song J, Chow C, Jahanshad N, van Royen N, Buschmann I, Madri JA, Mendizabal M, Sinusas AJ. Noninvasive Imaging of Angiogenesis With a 99mTc-Labeled Peptide Targeted at αvβ3 Integrin After Murine Hindlimb Ischemia. Circulation 2005, 111: 3255-3260. PMID: 15956134, DOI: 10.1161/circulationaha.104.485029.
- Zhu Q, Piao D, Sadeghi M, Zhang J, Chen Y, Sinusas A. A hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models. Proceedings Of SPIE--the International Society For Optical Engineering 2005, 5690: 356-364. DOI: 10.1117/12.592603.
- Piao D, Sadeghi MM, Zhang J, Chen Y, Sinusas AJ, Zhu Q. Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models. Journal Of Biomedical Optics 2005, 10: 044010-044010-10. PMID: 16178644, DOI: 10.1117/1.1954773.
- ZENG L, XU H, CHEW TL, CHISHOLM R, SADEGHI MM, KANWAR YS, DANESH FR. Simvastatin Modulates Angiotensin II Signaling Pathway by Preventing Rac1-Mediated Upregulation of p27. Journal Of The American Society Of Nephrology 2004, 15: 1711-1720. PMID: 15213258, DOI: 10.1097/01.asn.0000129839.91567.68.
- Sadeghi MM, Krassilnikova S, Zhang J, Gharaei AA, Fassaei HR, Esmailzadeh L, Kooshkabadi A, Edwards S, Yalamanchili P, Harris TD, Sinusas AJ, Zaret BL, Bender JR. Detection of Injury-Induced Vascular Remodeling by Targeting Activated αvβ3 Integrin In Vivo. Circulation 2004, 110: 84-90. PMID: 15210600, DOI: 10.1161/01.cir.0000133319.84326.70.
- Meoli DF, Sadeghi MM, Krassilnikova S, Bourke BN, Giordano FJ, Dione DP, Su H, Edwards DS, Liu S, Harris TD, Madri JA, Zaret BL, Sinusas AJ. Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction. Journal Of Clinical Investigation 2004, 113: 1684-1691. PMID: 15199403, PMCID: PMC420502, DOI: 10.1172/jci20352.
- Sadeghi MM, Schechner JS, Krassilnikova S, Gharaei AA, Zhang J, Kirkiles-Smith N, Sinusas AJ, Zaret BL, Bender JR. Vascular cell adhesion molecule-1-targeted detection of endothelial activation in human microvasculature. Transplantation Proceedings 2004, 36: 1585-1591. PMID: 15251390, DOI: 10.1016/j.transproceed.2004.05.060.
- Hua J, Bourke B, Song J, Chow C, Sadeghi M, Cavaliere P, Hu X, Jahanshad N, Dobrucki L, VanRoyen N, Mendizabal M, Buschmann I, Sinusas A. 1116-23 Noninvasive detection of angiogenesis with a technetium-99m labeled peptide targeted at αvβ3 integrin following hindlimb ischemia. Journal Of The American College Of Cardiology 2004, 43: a25. DOI: 10.1016/s0735-1097(04)90102-7.
- Zhu Q, Piao D, Sadeghi MM, Sinusas AJ. Simultaneous optical coherence tomography imaging and beta particle detection. Optics Letters 2003, 28: 1704-6. PMID: 13677543, DOI: 10.1364/ol.28.001704.
- Tatum JL, Narula J, Bender JR, Heller G, Sadeghi MM, Strauss HW: doi:10.1067.mnc.2003.391, Journal of Nuclear Cardiology, 2003; 10(2): 234-237
- Danesh FR, Sadeghi MM, Amro N, Philips C, Zeng L, Lin S, Sahai A, Kanwar YS. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 8301-8305. PMID: 12048257, PMCID: PMC123062, DOI: 10.1073/pnas.122228799.
- Sadeghi M, Tiglio A, Sadigh K, O’Donnell L, Collinge M, Pardi R, Bender J. INHIBITION OF INTERFERON-γ–MEDIATED MICROVASCULAR ENDOTHELIAL CELL MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II GENE ACTIVATION BY HMG-COA REDUCTASE INHIBITORS1. Transplantation 2001, 71: 1262-1268. PMID: 11397960, DOI: 10.1097/00007890-200105150-00014.
- Sadeghi M, Collinge M, Pardi R, Bender J. Simvastatin Modulates Cytokine-Mediated Endothelial Cell Adhesion Molecule Induction: Involvement of an Inhibitory G Protein. The Journal Of Immunology 2000, 165: 2712-2718. PMID: 10946302, DOI: 10.4049/jimmunol.165.5.2712.
- Bender JR, Sadeghi MM, Watson C, Pfau S, Pardi R. Heterogeneous activation thresholds to cytokines in genetically distinct endothelial cells: evidence for diverse transcriptional responses. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 3994-3998. PMID: 7513430, PMCID: PMC43709, DOI: 10.1073/pnas.91.9.3994.
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