Skip to Main Content

Imaging Tobacco Smoking Withdrawal using [11C]PHNO

  • Study HIC#:2000021470
  • Last Updated:07/15/2021

This research study is designed to look at the involvement of the dopamine systems in smoking, and the way people feel and think. This study will help us further examine brain chemistry and nicotine addiction. This study accepts both healthy non-smoker and healthy smoker subjects. Healthy non-smoker subjects will receive 1 PET scan with the radiotracer PHNO along with an amphetamine challenge and 1 mri . 

Healthy smoker subjects will be asked to quit smoking for up to 8 weeks and will receive up to 2 PET scans with the radiotracer PHNO along with 2 amphetamine challenges and 2 mris over the course of their abstinence. 

  • Age18 years - 55 years
  • GenderBoth
  • Start Date09/20/2017
  • End Date09/30/2022

Trial Purpose and Description

To determine amphetamine-induced DA release in nonsmokers and in tobacco smokers during acute and prolonged withdrawal. 

Eligibility Criteria

Volunteer Summary: This research study is designed to look at the involvement of the dopamine systems in smoking, and the way people feel and think. This study will help us further examine brain chemistry and nicotine addiction. This study accepts both healthy non-smoker and healthy smoker subjects. Healthy non-smoker subjects will receive 1 PET scan with the radiotracer PHNO along with an amphetamine challenge and 1 mri . Healthy smoker subjects will be asked to quit smoking for up to 8 weeks and will receive up to 2 PET scans with the radiotracer PHNO along with 2 amphetamine challenges and 2 mris over the course of their abstinence. 


Eligibility Criteria: -Ages 18-55 years -Able to read/write -Have no current uncontrolled medical condition such as neurological, cardiovascular, endocrine, renal, liver, or thyroid pathology -do not suffer from claustrophobia or any MR contradictions -not pregnant 

Accepts healthy volunteers: Yes 

Principal Investigator

Sub-Investigators

For more information about this study, contact:

Or contact the Help us Discover team on: