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Effect of Sleep Deprivation on Brain Imaging and Function

  • Study HIC#:1511016793
  • Last Updated:07/15/2021

This study involves a 1 hour MRS scan, a night of sleep deprivation about 1 week later followed by another 1 hour MRS scan the morning after sleep deprivation. (there is also an arm, that involves C13 MRS scans and the infusion of glucose,

  • Age18 years - 25 years
  • GenderBoth
  • Start Date05/05/2016
  • End Date12/31/2017

Trial Purpose and Description

To examine the effect of sleep deprivation on brain imaging and function.

We hypothesize that healthy persons will demonstrated decreases in brain function after one night of sleep deprivation, and that this change will be apparent via imaging techniques, as well.

Eligibility Criteria

Inclusion criteria

All participants:

a) Able to give written informed consent
b) Healthy males and females between ages 18-25
c) Have maintained a diurnal sleep schedule for the past year
d) Have the opportunity for at least 8 hours in bed nightly
e) No current evidence of insomnia (PSQI < 5; ISI <4; sleep onset latency < 30 minutes, time awake after sleep onset < 30 minutes, total sleep time > 6.5 hours)
f) No history of insomnia symptoms lasting more than 3 days consecutively, more than once in a year, or more than 5 times in their lifetime
g) No current, or history of, any DSM-IV diagnosis
h) No first-degree relative with history of psychotic, mood, or anxiety disorder.

Exclusion criteria
All participants:
a) Contraindications, such as the presence of ferromagnetic material in the body, or other non MR-compatible foreign bodies
b) For women: pregnancy, breastfeeding, or unprotected sex in the past 30 days
c) Use of psychoactive medication or drugs (but excluding caffeine and alcohol, see below) in the past 30 days
d) Serious medical or neurological illness that in the opinion of the PI would interfere with the scientific goals of the study or participant safety
e) History of mental illness, or current symptoms of mental illness that in the opinion of the PI would interfere with the scientific goals of the study or participant safety.
f) History of insomnia within the past year of study participation
g) Meet DSM-IV criteria for alcohol/illicit substance dependence in the past year or met alcohol/illicit substance abuse within past 6 months.
h) Typical use of more than 20 caffeinated beverages/week in the past year, or use of more than 10 caffeinated beverages in the past week (where 1 caffeinated beverage contains 100mg caffeine).
i) Current symptoms of a sleep disorder related to other conditions (e.g. sleep disordered breathing, restless leg syndrome, periodic limb movement disorder, chronic pain, gastro-esophageal reflux disease, sleep paralysis, nocturnal seizures, nocturia, enuresis, narcolepsy, REM behavior disorders), or a significant history of such conditions that in the opinion of the PI would interfere with the scientific goals of the study or participant safety.
j) Loss of consciousness for 5 minutes or more.
k) Active, significant suicidal ideation.

Principal Investigator

Sub-Investigators

  • Gerard Sanacora

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