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Neuroimaging Mechanisms by Which Memory and Glucocorticoids Promote Risky Drinking

  • Study HIC#:2000026404
  • Last Updated:09/24/2021

This is a research study of the brain, stress hormones, memory, and drinking. Study procedures will include: an intake visit to complete questionnaires, two MRI scans during which you will view pictures, and two visits to the Yale Stress Center to measure your memory for these pictures and complete an alcohol taste test. Before each scan, you will take a tablet that contains hydrocortisone, a steroid hormone that your body naturally produces, or a placebo pill that has no effect on your body. The main purpose of this study is to understand how hydrocortisone influences how our brains help us remember different types of information.

  • Age21 years - 45 years
  • GenderBoth
  • Start Date09/30/2019
  • End Date06/01/2023

Eligibility Criteria

Inclusion Criteria:

  • Between ages 21-45 years
  • Able to read and write English
  • BMI between 18-35
  • Beer drinking men and women.  

Exclusion Criteria:

  • Meet current criteria for any substance use disorder, excluding caffeine
  • Current significant medical conditions or psychiatric symptoms requiring medication
  • Current use of medications/drugs that interfere with the HPA axis response
  • Peri and post-menopausal women, pregnant or lactating women, and those with hysterectomies
  • Metal in body (for MRI safety)
  • Systemic fungal infections (contraindication for hydrocortisone)
  • Known hypersensitivity to components of hydrocortisone tablets (hydrocortisone, calcium stearate, corn starch, lactose, mineral oil, sorbic acid, sucrose)

Principal Investigator


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