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Brain Response Associated With Parent-based Treatment for Childhood Anxiety Disorders

  • Study HIC#:2000023649
  • Last Updated:12/22/2022

This study aims to investigate whether a parent-based treatment for childhood anxiety disorders engages child brain circuitry implicated in children's reliance on parents to reduce anxiety (R61), and whether change in child brain circuitry is associated with reduction in child anxiety (R33).

  • Age6 years - 12 years
  • GenderBoth
  • Start Date08/23/2018
  • End Date07/31/2023

Eligibility Criteria

Inclusion Criteria:

  • Prepubertal
  • Clinical diagnosis of primary anxiety disorder
  • Must not have another mental illness more impairing than the most impairing anxiety disorder
  • IQ of at least 80.

Exclusion Criteria:

  • Neurological disorders (including seizures)
  • Organic mental disorders, psychotic disorders, or pervasive developmental disorders
  • High likelihood of hurting themselves or others
  • Current psychosocial or psychopharmacological treatment
  • History of neurological illness or head injury with loss of consciousness > 5 minutes
  • Vision or physical disability that interferes with seeing stimuli presented briefly on computer screen and/or clicking a mouse button rapidly and repeatedly
  • Contraindications for MRI scanning (e.g., metal implants, pacemakers, braces, claustrophobia, pregnancy, weight > 250 pounds).


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