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Restless Legs Syndrome: The Role of Melanocortin Hormones

  • Study HIC#:2000026723
  • Last Updated:07/15/2021

Researchers at Yale University are conducting research to determine whether specific stress hormone levels are increased in the blood and cerebrospinal fluid of persons with RLS. This study requires a one-time visit to New Haven, Connecticut, you will be reimbursed for the COST OF YOUR TRAVEL (up to $600). Your first contact can be via email to at or call (203) 785-7393.

  • Age18 years and older
  • GenderBoth
  • Start Date12/11/2019
  • End Date12/30/2025

Trial Purpose and Description

The purpose of our study is to determine whether levels of melanocortin (MC) hormones are elevated in the serum and cerebrospinal fluid (CSF) of persons with restless legs syndrome (RLS) compared to controls without RLS. 

The secondary purpose of this study is to determine whether levels of MC hormones correlate to the severity of RLS symptoms, sleep disruption, frequency of periodic limb movements during sleep (PLMS), depression/suicidality, and/or pain sensitivity.

Eligibility Criteria

  1. Eligibility criteria: Above 18 years of age, with primary Restless Legs Syndrome or healthy volunteers, eligibility will be determined by research staff on the phone.

Principal Investigator

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